A technology selection framework for integrating manufacturing within a supply chain

This paper describes a structured analytical approach for selecting a manufacturing technology. A framework consisting of six integrated steps is proposed by considering the growing importance of supply chains in manufacturing organisations. The framework makes use of the analytical hierarchy process (AHP) approach combined with strategic assessment model (SAM) to evaluate and select the technologies appropriate for providing overall competitive advantage. The framework is intended to assist industrial managers in promoting manufacturing and supply chain collaboration and co-ordination by including intra-organisational perspective in their organisational technology selection decision making process.     

Factors Affecting Engineering Productivity

Engineering performance has a major impact on subsequent project phases, such as procurement and construction, and thus, has the potential to affect the overall project outcome. This study utilizes metrics and a database from the Construction Industry Institute (CII) benchmarking and metrics program to investigate relationships between factors thought to affect direct engineering labor productivity during detailed engineering. Collaborating with industry practitioners, quantitative assessments were analyzed with industry input through various CII committee meetings and industry forums. Significant correlations are found between engineering productivity and project size, project type, project priority, and phase involvement. Correlations are also found between degree of modularization, funded front-end planning effort, and quality management and engineering productivity. These findings extend and, in some cases, contradict previous research.     

A 4-Gene Signature of CDKN1, FDXR,SESN1 and PCNA Radiation Biomarkers for Prediction of Patient Radiosensitivity

The quest for the discovery and validation of radiosensitivity biomarkers is ongoing and while conventional bioassays are well established as biomarkers, molecular advances have unveiled new emerging biomarkers. Herein, we present the validation of a new 4-gene signature panel of CDKN1, FDXR, SESN1 and PCNA previously reported to be radiation-responsive genes, using the conventional G2 chromosomal radiosensitivity assay. Radiation-induced G2 chromosomal radiosensitivity at 0.05 Gy and 0.5 Gy IR is presented for a healthy control (n = 45) and a prostate cancer (n = 14) donor cohort. For the prostate cancer cohort, data from two sampling time points (baseline and Androgen Deprivation Therapy (ADT)) is provided, and a significant difference (p > 0.001) between 0.05 Gy and 0.5 Gy was evident for all donor cohorts. Selected donor samples from each cohort also exposed to 0.05 Gy and 0.5 Gy IR were analysed for relative gene expression of the 4-gene signature. In the healthy donor cohort, there was a significant difference in gene expression between IR dose for CDKN1, FXDR and SESN1 but not PCNA and no significant difference found between all prostate cancer donors, unless they were classified as radiation-induced G2 chromosomal radiosensitive. Interestingly, ADT had an effect on radiation response for some donors highlighting intra-individual heterogeneity of prostate cancer donors.     

Temperature evolution in a partially submerged approximate cheese cylinder

An approximate cheese cylinder is cooled while partially submerged in a flowing brine solution. Microbiological considerations require the cheese to be cooled to 4 °C or less prior to packaging. Knowledge of the temperature evolution of the product is desirable from a manufacturing perspective, and we propose a model to describe the temperature time-history of a single cheese cylinder during cooling. The combination of unusual product geometry and the discontinuity in surface temperatures motivate the use of the finite element method (FEM). The FEM solution is used to describe the cooling process, and to ascertain the minimum time necessary for the cheese to attain the required packaging temperature. The FEM solution exhibits excellent agreement with the corresponding experimental findings. The discontinuity in surface temperatures has a significant influence on the cooling regime. Future process optimisation should focus on developing methods to increase the cheese surface area in contact with the brine.