Using alum sludge for clay brick: an Irish investigation

Throughout the world, alum sludge is dewatered and the resultant cakes are discarded in landfill. This paper reports a study to investigate the possible incorporation of alum sludge as a partial replacement for clay in clay brick manufacturing. It is the first study of this problem in Ireland. Alum sludge cakes and clay were separately dried, ground and sieved in preparation for making test specimens. Cylindrical clay bricks were made at different temperatures (800, 1000, 1100, 1200 °C), incorporating different percentages (0, 5, 10, 15, 20, 30, 40% by dry weight) of alum sludge. The bricks were then subjected to compressive strength test and submersion. Loss on ignition, water absorption and weight reduction were calculated. It was found that bricks containing up to 20% sludge, fired at 1200 °C, or containing 5% sludge and fired at 1100 °C have met the European and Irish Standards as set out by Eurocode 6 – ‘Design of Masonry Structures’. The firing temperature and the increase in sludge content affected the final clay-sludge brick colour. By increasing the proportion of alum sludge, compressive strength decreased and the final weight of the brick was reduced. Firing temperatures that are too high may result in damage to the bricks during firing. This study has demonstrated the promising potential and prospects for Irish dewatered alum sludge cakes in clay-sludge brick making.     

Design, Development, and Deployment of a Rapid Universal Safety and Health System for Construction

Rapid construction projects and processes will become increasingly important as customers demand better project management performance and globally, as countries plan for and respond to the aftermath of natural and/or unnatural disasters. For use in expedited projects (as well as traditional projects), a rapid universal safety and health system (RUSH) was designed, developed, deployed, and evaluated. For its inaugural application, the RUSH was applied to a 106-hour construction project. Results from an initial application included a safe build in approximately 5?days without recordable incidents. More importantly, lessons were learned by a multidisciplinary team of researchers who observed safety 24/5 for the life of the project. Lessons learned and recommendations for future research are provided as a result of this experience.     

Correlation between the magnetic imaging of cobalt nanoconstrictions and their magnetoresistance response

Scanning transmission x-ray microscopy (STXM) and magnetoresistance (MR) measurements are used to investigate the magnetic behavior of a nanoconstriction joining two micrometric electrodes (a pad and a wire). The reversal of the magnetization under variable external static magnetic fields is imaged. By means of a detailed analysis of the STXM images at the nanocontact area, the MR is calculated, based on diffusive anisotropic-MR. This MR agrees well with that obtained from electrical transport measurements, allowing a direct correlation between the MR signal and the magnetic reversal of the system. The magnetization behavior depends on the sample thickness and constriction dimensions. In 40 nm-thick samples, with 20 × 175 nm(2) contact areas, the magnetization at the two sides of the constriction forms a net angle of 90°, with a progressive evolution of the magnetization structure between the electrodes during switching. The MR in those cases has a more peaked shape than with 20 nm-thick electrodes and 10 × 80 nm(2) contact areas, where the magnetization forms 180° between them, with a wide domain wall pinned at the constriction. As a consequence of this configuration, a plateau in the MR is observed for about 20 Oe.     

Precursor gas chemistry determines the crystallinity of carbon nanotubes synthesized at low temperature

Despite significant progress in carbon nanotube (CNT) synthesis by thermal chemical vapor deposition (CVD), the factors determining the structure of the resulting carbon filaments and other graphitic nanocarbons are not well understood. Here, we demonstrate that gas chemistry influences the crystal structure of carbon filaments grown at low temperatures (500 °C). Using thermal CVD, we decoupled the thermal treatment of the gaseous precursors (C₂H₄/H₂/Ar) and the substrate-supported catalyst. Varying the preheating temperature of the feedstock gas, we observed a striking transition between amorphous carbon nanofibers (CNFs) and crystalline CNTs. These results were confirmed using both a hot-wall CVD system and a cold-wall CVD reactor. Analysis of the exhaust gases (by ex situ gas chromatography) showed increasing concentrations of specific volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) that correlated with the structural transition observed (characterized using high-resolution transmission electron microscopy). This suggests that the crystallinity of carbon filaments may be controlled by the presence of specific gas phase precursor molecules (e.g., VOCs and PAHs). Thus, direct delivery of these molecules in the CVD process may enable selective CNF or CNT formation at low substrate temperatures. The inherent scalability of this approach could impact many promising applications, especially in the electronics industry.     

A new critical heat flux correlation for vertical water flow through multiple thin rectangular channels

A critical heat flux (CHF) study of the vertical up-flow of water through multiple thin rectangular channels was conducted. Pressures varied from 89.8 to 115 kPa, inlet temperatures from 291 to 306 K, and mass fluxes from 9.5 to 39 kg m^?2 s^?1. Electrical resistance heaters embedded in aluminum provided a uniform heat flux. A more universal and robust CHF correlation based on the geometry of the Advanced Test Reactor at Idaho National Laboratory was developed. This new CHF correlation predicts 126 data points from this and three previous studies within an error of ±8.5% with a 95% confidence.     

Evaluation of a novel radiopacifiying agent on the physical properties of surgical spineplex<Superscript>®</Superscript>

Polymethlylmethacrylate (PMMA) is the most frequently used cement for percutaneous vertebroplasty and kyphoplasty. To aid visualisation during surgery cements are doped with radiopacifying agents such as Barium sulphate (Ba₂SO₄) or Zirconium Dioxide (ZiO₂). Mounting research suggests that these agents may impair the biocompatibility of the cements. However, incorporating an alternative radiopacifier agent with excellent biocompatibility would be a significant step forward. Bioactive radiopaque glasses incorporating elements such as strontium (Sr) and zinc (Zn), known to have beneficial and therapeutic effects on bone, are of great interest in this respect. In this study, the Ba₂SO₄ of the commercially available Spineplex^® was incrementally replaced with a radiopaque therapeutic glass composition. The resulting effects on cement setting time, peak isotherm, ultimate compressive strength, Young’s modulus (up to 30 days cement maturation) and radiopacity were evaluated. The substitution lead to an increase in cement setting time from 13.1 mins for Spineplex^® to 16.6–18.3 mins for the glass substituted cements. The peak exotherm during curing was reduced from 74°C for Spineplex^® to a minimum of 51°C for the fully substituted cement, indicating that reduced thermal necrosis in the in vivo setting is likely with these materials. Ultimate compressive strength and Young’s modulus of each formulation showed no significant deterioration due to the substitution. Finally, the radiopacity of the substituted cements were reduced by up to a maximum of 18% in comparison to the control. However, the experimental formulations still maintained radiopacity equivalent to several millimetres of aluminium. As such the substituted cements had substantial equivalence to the Spineplex^® control. In order to assess the clinical relevance of these findings further investigation is warranted.     

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Non-viral gene delivery has become a popular approach in tissue engineering, as it permits the transient delivery of a therapeutic gene, in order to stimulate tissue repair. However, the efficacy of non-viral delivery vectors remains an issue. Our lab has created gene-activated scaffolds by incorporating various non-viral delivery vectors, including the glycosaminoglycan-binding enhanced transduction (GET) peptide into collagen-based scaffolds with proven osteogenic potential. A modification to the GET peptide (FLR) by substitution of arginine residues with histidine (FLH) has been designed to enhance plasmid DNA (pDNA) delivery. In this study, we complexed pDNA with combinations of FLR and FLH peptides, termed GET* nanoparticles. We sought to enhance our gene-activated scaffold platform by incorporating GET* nanoparticles into collagen–nanohydroxyapatite scaffolds with proven osteogenic capacity. GET* N/P 8 was shown to be the most effective formulation for delivery to MSCs in 2D. Furthermore, GET* N/P 8 nanoparticles incorporated into collagen–nanohydroxyapatite (coll–nHA) scaffolds at a 1:1 ratio of collagen:nanohydroxyapatite was shown to be the optimal gene-activated scaffold. pDNA encoding stromal-derived factor 1α (pSDF-1α), an angiogenic chemokine which plays a role in BMP mediated differentiation of MSCs, was then delivered to MSCs using our optimised gene-activated scaffold platform, with the aim of significantly increasing angiogenesis as an important precursor to bone repair. The GET* N/P 8 coll–nHA scaffolds successfully delivered pSDF-1α to MSCs, resulting in a significant, sustained increase in SDF-1α protein production and an enhanced angiogenic effect, a key precursor in the early stages of bone repair.     

Chronic Effects of a High Sucrose Diet on Murine Gastrointestinal Nutrient Sensor Gene and Protein Expression Levels and Lipid Metabolism

The gastrointestinal tract (GIT) plays a key role in regulating nutrient metabolism and appetite responses. This study aimed to identify changes in the GIT that are important in the development of diet related obesity and diabetes. GIT samples were obtained from C57BL/6J male mice chronically fed a control diet or a high sucrose diet (HSD) and analysed for changes in gene, protein and metabolite levels. In HSD mice, GIT expression levels of fat oxidation genes were reduced, and increased de novo lipogenesis was evident in ileum. Gene expression levels of the putative sugar sensor, slc5a4a and slc5a4b, and fat sensor, cd36, were downregulated in the small intestines of HSD mice. In HSD mice, there was also evidence of bacterial overgrowth and a lipopolysaccharide activated inflammatory pathway involving inducible nitric oxide synthase (iNOS). In Caco-2 cells, sucrose significantly increased the expression levels of the nos2, iNOS and nitric oxide (NO) gas levels. In conclusion, sucrose fed induced obesity/diabetes is associated with changes in GI macronutrient sensing, appetite regulation and nutrient metabolism and intestinal microflora. These may be important drivers, and thus therapeutic targets, of diet-related metabolic disease.