Approximate Equilibria and Ball Fusion

We consider selfish routing over a network consisting of m parallel links through which $n$ selfish users route their traffic trying to minimize their own expected latency. We study the class of mixed strategies in which the expected latency through each link is at most a constant multiple of the optimum maximum latency had global regulation been available. For the case of uniform links it is known that all Nash equilibria belong to this class of strategies. We are interested in bounding the coordination ratio (or price of anarchy) of these strategies defined as the worst-case ratio of the maximum (over all links) expected latency over the optimum maximum latency. The load balancing aspect of the problem immediately implies a lower bound Ω(ln m ln ln m) of the coordination ratio. We give a tight (up to a multiplicative constant) upper bound. To show the upper bound, we analyze a variant of the classical balls and bins problem, in which balls with arbitrary weights are placed into bins according to arbitrary probability distributions. At the heart of our approach is a new probabilistic tool that we call ball fusion; this tool is used to reduce the variant of the problem where balls bear weights to the classical version (with no weights). Ball fusion applies to more general settings such as links with arbitrary capacities and other latency functions.     

Reliable Distributed Network Management by Replication

This paper presents a new clustering architecture for SNMP agents that supports semi-active replication of managed objects. A cluster of agents provides fault-tolerant object functionality: replicated managed objects of a crashed agent of a given cluster may be accessed through a peer cluster. The proposed architecture is structured in three layers. The lower layer corresponds to the managed objects at the network elements. The middle layer contains management entities called clusters that monitor and replicate managed objects. The upper layer allows the definition of management clusters as well as the relationship between clusters. A practical tool was implemented and is presented. The impact of replication on network performance is evaluated as well as a probabilistic analysis of replicated object consistency.     

Gradient material mechanics: Perspectives and Prospects

This is a modest contribution dedicated to the work and virtue of George Weng, a prominent figure in material mechanics and a dear intellectual friend. The paper starts with the basics of gradient theory as applied to elasticity, plasticity and dislocation dynamics by introducing weak non-locality in the constitutive equations through Laplacian terms and corresponding deterministic internal lengths (ILs) characterizing the dominant deformation mechanisms. It then considers the interaction of such deterministic ILs with surface effects associated with internal or external surfaces, as well as stochastic effects associated with pre-existing or deformation-induced random microstructures. Experimentally observed stress drops and strain bursts are interpreted through combined gradient-stochastic models. Statistical features of corresponding deformation processes that cannot be fitted with Boltzmann–Gibbs–Shannon entropy statistics are interpreted by Tsallis q-entropy statistics. Some benchmark novel experiments for the direct determination of ILs for plasticity (by testing bulk specimens with gradient grain size) and dislocation dynamics (by testing thin films in TEM with gradient dislocation density) are proposed.     

Relation between dairy food intake and cognitive function: The Maine-Syracuse Longitudinal Study

Diet modification to alter the course of age-related cognitive decline is becoming increasingly important. Few observational findings suggest that dairy food intake may be positively related to cognitive function, but research in this novel area is limited. The aim of this study was to investigate whether dairy food intake is associated with cognitive function, before and after adjustment for cardiovascular, lifestyle and dietary factors. To do this, a cross-sectional analyses of a subset of the community-based Maine-Syracuse Longitudinal Study (MSLS) sample (N = 972) was undertaken. It was determined that participants who consumed dairy products at least once per day had significantly higher scores on multiple domains of cognitive function compared with those who never or rarely consumed dairy foods, adjusting for cardiovascular risk factors, lifestyle and dietary factors. Frequent dairy food intake is associated with better cognitive performance but underlying causal mechanisms are still to be determined.     

Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion

With the number of deaths due to stroke decreasing, more individuals are forced to live with crippling disability resulting from the stroke. To date, no therapeutics exist after the first 4.5 h after the stroke onset, aside from rest and physical therapy. Following stroke, a large influx of astrocytes and microglia releasing proinflammatory cytokines leads to dramatic inflammation and glial scar formation, affecting brain tissue's ability to repair itself. Pathological conditions, such as a stroke, trigger neural progenitor cells (NPCs) proliferation and migration toward the damaged site. However, these progenitors are often found far from the cavity or the peri‐infarct tissue. Poststroke tissue remodeling results in a compartmentalized cavity that can directly accept a therapeutic material injection. Here, this paper shows that the injection of a porous hyaluronic acid hydrogel into the stroke cavity significantly reduces the inflammatory response following stroke while increasing peri‐infarct vascularization compared to nonporous hydrogel controls and stroke only controls. In addition, it is shown that the injection of this material impacts NPCs proliferation and migration at the subventricular zone niche and results, for the first time, in NPC migration into the stroke site.     

Rapid Aging as a Key to Understand Deactivation of Ni/Al2O3 Catalysts Applied for the CO2 Methanation

Catalysis Letters - We developed a rapid aging method for Ni/Al2O3 methanation catalysts mimicking the real aging in the actual application. The method is based on hydrothermal deactivation of the...     

Development of a long‐life vacuum‐packaged ready‐to‐eat meat product based on a traditional Portuguese seasoned meat

Carne do alguidar is a Portuguese traditional pork fried meat, usually manufactured for self‐consumption purposes. This study developed a ready‐to‐eat (RTE) meat product, to meet today's consumers’ convenience, manufactured at the industrial scale evaluating its quality and shelf life, assessing the effect of vacuum packaging and the use of an antioxidant (50 ppm BHT) to enhance oxidative stability. Physicochemical and microbiological parameters were assessed, and a sensory analysis was performed. Interestingly, no significant differences were recorded between control (non‐BHT) and antioxidant (BHT) samples. Microbiological counts remained at low levels throughout the storage period, ensuring the product's required microbiological quality. At later storage stages, higher values of thiobarbituric acid‐reactive substances arose and off flavours and aromas were perceived. Still, overall appreciation was not affected until 12 months of storage and a significant depreciation was perceived only after 15 months. Fibrousness and rising of off flavours were negatively correlated with overall appreciation.     

Influence of Surface Morphology on the Torsion Fracture of NiTi Endodontic Instruments

This study analyzed the influences of manufacturing process (twisting and machining) and surface finishing on the angular distortion, maximum torque, and toughness of two NiTi endodontic instruments (Race—FKG Dentaire and TF—Twisted Files, SybronEndo). Statistical analysis of results showed that TF instruments (twisted) had higher distortion angle (p < 0.05) and lower maximum torque to fracture (p < 0.05) than Race instruments (machined). SEM analysis of fractured instruments showed a surface morphology characteristic of ductile fracture, with plastic deformation in the helical shafts. The results suggest that both instruments are equally suitable for clinical applications. This study is purely scientific as it evaluates only some material properties, and is not intended to endorse a commercial product.     

Purification Processes and Market Potential of Bromelain in Brazil

Bromelain is the denomination given to the group of endoproteases obtained from members of Bromeliacea family. These enzymes have a wide range of proven applications and have been an object of study for worldwide researchers for decades. Over the years, several different downstream processes were studied in order to determine which technique would be worthwhile to be implemented in Brazil and provide the national market with such product. The objective of the present study is to relate the main studies in Brazil that has proven that bromelain purification can be cost-effective, in addition to the well-known benefits owned by such enzymes, and highlight the applications that create their market potential in the Brazilian market.