3D Printed Enzyme-Functionalized Scaffold Facilitates Diabetic Bone Regeneration

Patients with diabetes mellitus (DM) suffer from a high risk of fractures and poor bone healing ability. Surprisingly, no effective therapy is available to treat diabetic bone defect in clinic. Here, a 3D printed enzyme-functionalized scaffold with multiple bioactivities including osteogenesis, angiogenesis, and anti-inflammation in diabetic conditions is proposed. The as-prepared multifunctional scaffold is constituted with alginate, glucose oxidase (GOx), and catalase-assisted biomineralized calcium phosphate nanosheets (CaP@CAT NSs). The GOx inside scaffolds can alleviate the hyperglycemia environment by catalyzing glucose and oxygen into gluconic acid and hydrogen peroxide (H₂O₂). Both the generated H₂O₂ as well as the overproduced H₂O₂ in DM can be scavenged by CaP@CAT NSs, while the initiated hypoxic microenvironment stimulates neovascularization. Moreover, the incorporation of CaP@CAT NSs not only enhance the mechanical property of the scaffolds, but also facilitate bone regeneration by the degraded Ca²⁺ and PO₄³⁻ ions. The remarkable in vitro and in vivo outcomes demonstrate that enzymes functionalized scaffolds can be an effective strategy for enhancing bone tissue regeneration in diabetic conditions, underpinning the potential of multifunctional scaffolds for diabetic bone regeneration.     

A Robust Wearable Point-of-Care CNT-Based Strain Sensor for Wirelessly Monitoring Throat-Related Illnesses

Point-of-care testing (POC) has the ability to detect chronic and infectious diseases early or at the time of occurrence and provide a state-of-the-art personalized healthcare system. Recently, wearable and flexible sensors have been employed to analyze sweat, glucose, blood, and human skin conditions. However, a flexible sensing system that allows for the real-time monitoring of throat-related illnesses, such as salivary parotid gland swelling caused by flu and mumps, is necessary. Here, for the first time, a wearable, highly flexible, and stretchable piezoresistive sensing patch based on carbon nanotubes (CNTs) is reported, which can record muscle expansion or relaxation in real-time, and thus act as a next-generation POC sensor. The patch offers an excellent gauge factor for in-plane stretching and spatial expansion with low hysteresis. The actual extent of muscle expansion is calculated and the gauge factor for applications entailing volumetric deformations is redefined. Additionally, a bluetooth-low-energy system that tracks muscle activity in real-time and transmits the output signals wirelessly to a smartphone app is utilized. Numerical calculations verify that the low stress and strain lead to excellent mechanical reliability and repeatability. Finally, a dummy muscle is inflated using a pneumatic-based actuator to demonstrate the application of the affixed wearable next-generation POC sensor.     

A closed-loop healthcare processing approach based on deep reinforcement learning

Multimedia Tools and Applications - In healthcare, the human body is a controlled input-output system, which generates different observations with the variations of external interventions. The...     

Multiple RGB images encryption algorithm based on elliptic curve,improved Diffie Hellman protocol

Multimedia Tools and Applications - For the asymmetric key, the Diffie Hellman Key (DHK) protocol is very efficient, but sometimes it is vulnerable against brute force attacks if the parameters are...     

Emulating Software Defined Network using Mininet-ns3-WIFI Integration for Wireless Networks

SDN enables a new networking paradigm probable to improve system efficiency where complex networks are easily managed and controlled. SDN allows network virtualization and advance programmability for customizing the behaviour of networking devices with user defined features even at run time. SDN separates network control and data planes. Intelligently controlled network management and operation, such that routing is eliminated from forwarding elements (switches) while shifting the routing logic in a centralized module named SDN Controller. Mininet is Linux based network emulator which is cost effective for implementing SDN having in built support of OpenFlow switches. This paper presents practical implementation of Mininet with ns-3 using Wi-Fi. Previous results reported in literature were limited upto 512 nodes in Mininet. Tests are conducted in Mininet by varying number of nodes in two distinct scenarios based on scalability and resource capabilities of the host system. We presented a low cost and reliable method allowing scalability with authenticity of results in real time environment. Simulation results show a marked improvement in time required for creating a topology designed for 3 nodes with powerful resources i.e. only 0.077 sec and 4.512 sec with limited resources, however with 2047 nodes required time is 1623.547 sec for powerful resources and 4615.115 sec with less capable resources respectively.

     

Sustainable Green Fog Computing for Smart Agriculture

Wireless Personal Communications - Medical Body Area Networks or MBANs are gaining popularity in healthcare circles because of the convenience they provide to patients and caregivers and assist in...     

Novel Cost Efficient Resource Allocation Technique Based on Deadline and Budget Constraints for Edge Users

Wireless Personal Communications - The edge computing paradigm has experienced quick development in recent years. This paradigm is featured by pushing the storage and computational resources closer...     

Design and deployment challenges in immersive and wearable technologies

The current century has brought an unimaginable growth in information and communications technology (ICT) and needs of enormous computing. The advancements in computer hardware and software particularly helped fuel the requirements of human beings, and revolutionized the smart products as an outcome. The advent of wearable devices from their development till successful materialisation has only taken less than a quarter of a century. The huge benefits of these smart wearable technologies cannot be fully enjoyed until and unless the reliability of a complete system is ensured. The reliability can be increased by the consistent advancements in hardware and software in parallel. User expectations actually are the challenges that keep the advancements alive while improving at an unmatchable pace. The future of wearable and other smart devices depends on whether they can provide a timely solution that is reliable, richer in resources, smaller in size, and cheaper in price. This paper addresses the threats and opportunities in the development and the acceptance of immersive and wearable technologies. The hardware and software challenges for the purpose of development are discussed to demonstrate the bottlenecks of the current technologies and the limitations that impose those bottlenecks. For the purpose of adoption, social and commercial challenges related to innovation and acceptability are discussed. The paper proposes guidelines that are expected to be applicable in several considerable applications of wearable technologies, for example, social networks, healthcare, and banking.