Macro- and microscale variables regulate stent haemodynamics,fibrin deposition and thrombomodulin expression

Drug eluting stents are associated with late stent thrombosis (LST), delayed healing and prolonged exposure of stent struts to blood flow. Using macroscale disturbed and undisturbed fluid flow waveforms, we numerically and experimentally determined the effects of microscale model strut geometries upon the generation of prothrombotic conditions that are mediated by flow perturbations. Rectangular cross-sectional stent strut geometries of varying heights and corresponding streamlined versions were studied in the presence of disturbed and undisturbed bulk fluid flow. Numerical simulations and particle flow visualization experiments demonstrated that the interaction of bulk fluid flow and stent struts regulated the generation, size and dynamics of the peristrut flow recirculation zones. In the absence of endothelial cells, deposition of thrombin-generated fibrin occurred primarily in the recirculation zones. When endothelium was present, peristrut expression of anticoagulant thrombomodulin (TM) was dependent on strut height and geometry. Thinner and streamlined strut geometries reduced peristrut flow recirculation zones decreasing prothrombotic fibrin deposition and increasing endothelial anticoagulant TM expression. The studies define physical and functional consequences of macro- and microscale variables that relate to thrombogenicity associated with the most current stent designs, and particularly to LST.     

In situ metal ion contamination and the effects on proton exchange membrane fuel cell performance

Automotive fuel cell technology has made considerable progress, and hydrogen fuel cell vehicles are regarded as a possible long-term solution to reduce carbon dioxide emissions, reduce fossil fuel dependency and increase energy efficiency. Even though great strides have been made, durability is still an issue. One key challenge is controlling MEA contamination. Metal ion contamination within the membrane and the effects on fuel cell performance were investigated. Given the possible benefits of using stainless steel or aluminum for balance-of-plant components or bipolar plates, cations of Al, Fe, Ni and Cr were studied. Membranes were immersed in metal sulfide solutions of varying concentration and then assembled into fuel cell MEAs tested in situ. The ranking of the four transition metals tested in terms of the greatest reduction in fuel cell performance was: Al³⁺ ? Fe²⁺ > Ni²⁺, Cr³⁺. For iron-contaminated membranes, no change in cell performance was detected until the membrane conductivity loss was greater than approximately 15%.     

Australia,uranium and nuclear power

The nuclear debate in Australia is shaped by the nation's substantial base of energy resources, including its large reserves of uranium and recent rises in the market price of uranium. But the debate also echoes Australia's past in the development of programs for nuclear weapons. The proposals include uranium enrichment, the storage of nuclear waste in Australia, and the introduction of nuclear reactors. A national inquiry has been instituted by the government. These developments, stemming from a range of factors, have revived the opposition to uranium mining and nuclear power which has for two decades held a dominant role in Australian politics. The issue of what should be Australia's energy path in a time of climate change is beginning to be examined. The importance of the decisions, whether to be a player in the nuclear club with its attendant multiple hazards, or to play a quite different leadership role in the development and adoption of sustainable energy strategies and technologies, cannot be exaggerated.     

Negotiation‐based decision support model for utility relocations in transportation infrastructure projects

Highway projects in metropolitan areas often require that adjacent utilities be relocated to accommodate new or expanded highway facilities. Traditionally, utility owners have been responsible for their own relocations prior to highway construction. However, utility relocation delay was reported as one of the root causes of overall project delays in highway construction. In the USA, one strategic approach sporadically taken over the past 15 years by some state departments of transportation (DOTs) has been to combine utility relocation work with the highway contractor's scope of work. While the combined strategy offers many benefits, it does have its own set of challenges and disadvantages. Many of these difficulties involve disagreements between DOTs and utility owners over the appropriateness of the combined strategy for particular types of relocations. Hence, a negotiation‐based decision support model (DSM) for determining whether to use the combined strategy was developed to provide guidance to both DOTs and utility decision makers during the planning and design phases of highways. A literature review and interviews with experts from both DOTs and the utility industry were conducted to identify significant factors as well as their impact levels on the decision. A DSM aiming at synthesizing the factors and orchestrating the negotiation process for the decision was proposed and verified. As suggested by the model evaluators, the proposed DSM can improve the quality of this complex decision‐making process, especially for less experienced project managers or designers.     

Modelling the dynamics of design error induced rework in construction

Rework that is experienced in construction projects is often caused by errors made during the design process. Factors that contribute to design errors are identified and used to design and develop a systems dynamics model, which is used to simulate a number of practical scenarios that can be used to reduce design errors and rework. The model presented in this paper can enable design and project managers to understand better the process of design documentation and how design errors occur in construction projects.     

Urbanization Effect on Floristic and Landscape Patterns of Green Spaces

The study explored the effects of intensive urbanization on urban plant diversity and landscape pattern. An inventory of plant species in managed green spaces in the nine urban districts of Guangzhou (south China) with varied development history was conducted. The relationships among species richness, diversity and urban development were analysed by community ecology attributes, cluster analysis, growth-form differentiation and district fidelity indices, and statistical tests. The 1055 vascular species were dominated by a small number of common evergreen species, accompanied by many rare species. By species richness, tree was the dominant growth form, followed by herb and shrub. Species richness and diversity were slightly below urban-fringe secondary forests. Old and young districts offered disparate conditions for species enrichment to establish urban landscape patterns with divergent floristic and growth-form assemblages. Urban species profile and vegetation landscapes were mainly influenced by planning and management of the urban landscape and changing landscape fashion.