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Omer Qadir Alex Lenz Gianluca Tempesti Jon Timmis Tony Pipe Andy Tyrrell 《Genetic Programming and Evolvable Machines》2014,15(3):245-274
The Protein Processor Associative Memory (PPAM) is a novel hardware architecture for a distributed, decentralised, robust and scalable, bidirectional, hetero-associative memory, that can adapt online to changes in the training data. The PPAM uses the location of data in memory to identify relationships and is therefore fundamentally different from traditional processing methods that tend to use arithmetic operations to perform computation. This paper presents the hardware architecture and details a sample digital logic implementation with an analysis of the implications of using existing techniques for such hardware architectures. It also presents the results of implementing the PPAM for a robotic application that involves learning the forward and inverse kinematics. The results show that, contrary to most other techniques, the PPAM benefits from higher dimensionality of data, and that quantisation intervals are crucial to the performance of the PPAM. 相似文献
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Efficient registration of optical and infrared images via modified Sobel edging for plant canopy temperature estimation 总被引:1,自引:0,他引:1
Weiping YangAuthor Vitae Xuezhi WangAuthor VitaeBill MoranAuthor Vitae Ashley WheatonAuthor VitaeNicola CooleyAuthor Vitae 《Computers & Electrical Engineering》2012,38(5):1213-1221
Automatic optical and infrared (IR) image registration is a crucial requirement in the estimation of plant canopy temperature. The latter is used to compute the plant water stress status which can potentially be applied to an automated control system for optimal crop irrigation management. Due to the nature of image sources and plant scene, it is difficult to find enough common features between the pair of images to register them using a simple method. In this paper an improved registration algorithm is described, where a modified Sobel edge detector is adopted and a variable resolution scheme is applied. The algorithm can improve the registration efficiency considerably compared to our previous developed registration method. Experiment results show that the modified algorithm can achieve the same registration accuracy and a better success rate compared to that from the original algorithm with a substantial reduction of computational complexity. 相似文献
106.
Kristi L. Helke M.A. McCrackin Ashley M. Galloway Ann Z. Poole Cassandra D. Salgado 《Critical reviews in food science and nutrition》2017,57(3):472-488
Controversy continues concerning antimicrobial use in food animals and its relationship to drug-resistant infections in humans. We systematically reviewed published literature for evidence of a relationship between antimicrobial use in agricultural animals and drug-resistant meat or dairy-borne non-typhoidal salmonellosis in humans. Based on publications from the United States (U.S.), Canada, and Denmark from January 2010 to July 2014, 858 articles received title and abstract review, 104 met study criteria for full article review with 68 retained for which data are presented. Antibiotic exposure in both cattle and humans found an increased likelihood of Salmonella colonization, whereas in chickens, animals not exposed to antibiotics (organic) were more likely to be Salmonella positive and those that had antibiotic exposure were more likely to harbor antimicrobial resistant Salmonella organisms. In swine literature, only tylosin exposure was examined and no correlation was found among exposure, Salmonella colonization, or antimicrobial resistance. No studies that identified farm antimicrobial use also traced antimicrobial-resistant Salmonella from farm to fork. 相似文献
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Dan A. Buzatu Willie M. Cooper Christine Summage-West John B. Sutherland Anna J. Williams Deborah A. Bass Lisa L. Smith Robert S. Woodruff Jessica M. Christman Steven Reid Randal K. Tucker Christopher J. Haney Ashfaqe Ahmed Fatemeh Rafii Jon G. Wilkes 《Food microbiology》2013
A flow cytometric method (RAPID-B™) with detection sensitivity of one viable cell of Escherichia coli serotype O157:H7 in fresh spinach (Spinacia oleracea) was developed and evaluated. The major impediment to achieving this performance was mistaking autofluorescing spinach particles for tagged target cells. Following a 5 h non-selective enrichment, artificially inoculated samples were photobleached, using phloxine B as a photosensitizer. Samples were centrifuged at high speed to concentrate target cells, then gradient centrifuged to separate them from matrix debris. In external laboratory experiments, RAPID-B and the reference method both correctly detected E. coli O157:H7 at inoculations of ca. 15 cells. In a follow-up study, after 4 cell inoculations of positives and 6 h enrichment, RAPID-B correctly identified 92% of 25 samples. The RAPID-B method limit of detection (LOD) was one cell in 25 g. It proved superior to the reference method (which incorporated real time-PCR, selective enrichment, and culture plating elements) in accuracy and speed. 相似文献
108.
Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity 下载免费PDF全文
Ashley V. Kroll Ronnie H. Fang Yao Jiang Jiarong Zhou Xiaoli Wei Chun Lai Yu Jie Gao Brian T. Luk Diana Dehaini Weiwei Gao Liangfang Zhang 《Advanced materials (Deerfield Beach, Fla.)》2017,29(47)
Anticancer vaccines train the body's own immune system to recognize and eliminate malignant cells based on differential antigen expression. While conceptually attractive, clinical efficacy is lacking given several key challenges stemming from the similarities between cancerous and healthy tissue. Ideally, an effective vaccine formulation would deliver multiple tumor antigens in a fashion that potently stimulates endogenous immune responses against those antigens. Here, it is reported on the fabrication of a biomimetic, nanoparticulate anticancer vaccine that is capable of delivering autologously derived tumor antigen material together with a highly immunostimulatory adjuvant. The two major components, tumor antigens and adjuvant, are presented concurrently in a fashion that maximizes their ability to promote effective antigen presentation and activation of downstream immune processes. Ultimately, it is demonstrated that the formulation can elicit potent antitumor immune responses in vivo. When combined with additional immunotherapies such as checkpoint blockades, the nanovaccine demonstrates substantial therapeutic effect. Overall, the work represents the rational application of nanotechnology for immunoengineering and can provide a blueprint for the future development of personalized, autologous anticancer vaccines with broad applicability. 相似文献
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Virginia R. Stovin Sarah L. Moore Matthew Wall Richard M. Ashley 《Water and Environment Journal》2013,27(2):216-228
Experience of retrofitting sustainable drainage systems (SuDS) in the United Kingdom is limited, and there are no well‐established procedures for evaluating the feasibility, value or cost‐effectiveness of doing this, particularly at the catchment scale. This paper demonstrates a two‐phase process for evaluating the potential to retrofit SuDS to address combined sewer discharges in three subcatchments within the Thames Tideway catchment of London. The first phase evaluates what might be achieved with various levels of disconnection (‘global’ disconnection scenarios) using hydraulic models, while the second phase considers how disconnection might practically be achieved. High levels of disconnection are technically possible but practicably difficult. In selected cases, and with aggressive implementation of SuDS, combined sewer overflow CSO discharges could potentially be eliminated or reduced to acceptable levels without the need for any modifications to underground assets. However, retrofit SuDS could not eliminate the requirement for some form of sewer modification in any subcatchments. 相似文献