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61.
Cássia A. Glasser Marta M. D. C. Vila Júlio C. Pereira Marco V. Chaud José M. Oliveira Júnior Matthieu Tubino 《Drug development and industrial pharmacy》2016,42(12):1990-2000
The aqueous-core enclosed in lipid nanoballoons integrating multiple emulsions of the type water-in-oil-in-water mimic, at least in theory, the environment within viable cells, thus being suitable for housing hydrophilic protein entities such as bioactive proteins, peptides and bacteriophage particles. This study reports a complete physicochemical characterization of optimized biomimetic aqueous-core lipid nanoballoons housing hydrophilic (BSA) protein entities, evolved from a statistical 23×31 factorial design study (three variables at two levels and one variable at three levels) that was the subject of the first paper of a series of three, aiming at complete stabilization of the three-dimensional structure of protein entities attempted via housing the said molecular entities within biomimetic aqueous-core lipid nanoballoons integrating a multiple (W/O/W) emulsion. The statistical factorial design followed led to the production of an optimum W/O/W multiple emulsion possessing quite homogeneous particles with an average hydrodynamic size of (186.2?±?2.6) nm and average Zeta potential of (?36.5?±?0.9) mV, and exhibiting a polydispersity index of 0.206?±?0.014. Additionally, the results obtained for the diffusion coefficient of the lipid nanoballoons integrating the optimized W/O/W multiple emulsion were comparable and of the same order of magnitude (10?12 m2 s?1) as those published by other authors since, typically, diffusion coefficients for molecules range from 10?10 to 10?7 m2 s?1, but diffusion coefficients for nanoparticles are typically of the order of magnitude of 10?12 m2 s?1. 相似文献
62.
A Castro Beiras JL Escudero Pereira A Juffe Stein CM Sánchez J Caramés Bouzán 《Canadian Metallurgical Quarterly》1998,51(8):611-619
The present work describes the process by which the pilot project of clinical management of the Hospital Complex Juan Canalejo, designated as "Heart Area", was implemented. In the first section, the needs and reasons that led to the undertaking of this project are explained. The project's objectives and operative strategies are listed. In the Material and Methods section, three basic aspects of the "Heart Area" are described: selection criteria of the "Area", its structure and function, and its foundation and development. In the Results section, we compare the activity undertaken in the "Area" to the situation present prior to its implementation, in relation to quality and costs. Finally, in the Conclusions, we comment on the important implications that our project can have within the Hospital Complex Juan Canalejo as well as in the health care field in general. 相似文献
63.
S Sundaram TW Barrett KB Meyer C Perrella MC Neto AJ King BJ Pereira 《Canadian Metallurgical Quarterly》1996,7(10):2183-2191
The widespread use of bicarbonate dialysate and reprocessed high-efficiency and "high-flux" dialyzers has raised concerns about the increased risk of reverse-transfer of dialysate contaminants into the blood compartment. To evaluate this concern, the reverse-transfer of bacterial products from contaminated bicarbonate dialysate into the blood compartment was compared during in vitro dialysis with new or reprocessed high-flux polysulfone dialyzers. In vitro dialysis was carried out at 37 degrees C by use of a counter-current recirculating loop dialysis circuit with either new high-flux polysulfone dialyzers or dialyzers reprocessed once or 20 times with formaldehyde (0.75%) and bleach (< 1%) with an automated system. Heparinized whole blood from healthy volunteers was circulated through the blood compartment, and bicarbonate dialysate was circulated in the dialysate compartment. The dialysate was challenged sequentially by 1:1000 and 1:100 dilutions of a sterile Pseudomonas aeruginosa culture supernatant (bacterial challenge). Samples were drawn from the blood and dialysate compartments 1 h after each challenge. Peripheral blood mononuclear cells (PBMC) were harvested by Ficoll-Hypaque separation from whole blood in the blood compartment and a 5 x 10(6) PBMC/mL cell suspension was prepared. Likewise, dialysate samples (0.5 mL) were added to 0.5 mL suspension of 5 x 10(6) PBMC/mL drawn at baseline. All PBMC suspensions were incubated upright in a humidified atmosphere at 37 degrees C with 5% CO2 for 24 h, and total interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF alpha) cytokine production (cell-associated and secreted) was measured by radioimmunoassay. Eight experiments were performed for each arm of the study with the same donor for each arm. One hour after contaminating the dialysate with a 1:1000 dilution of the bacterial challenge, IL-1 alpha production by PBMC harvested from the blood compartment was 160 +/- 0, 171 +/- 11, and 270 +/- 35 pg, respectively, for new dialyzers, dialyzers reprocessed once, and dialyzers reprocessed 20 times (P = 0.004). One hour after challenging the dialysate with 1:100 dilution, IL-1 alpha production by PBMC harvested from the blood compartment was 188 +/- 20, 228 +/- 35, and 427 +/- 67 pg, respectively, for new dialyzers, dialyzers reprocessed once, and dialyzers reprocessed 20 times (P = 0.006). IL-1 alpha production by PBMC from dialyzers reprocessed 20 times was significantly greater than both new and dialyzers reprocessed once. However, there were no significant differences between new dialyzers and dialyzers reprocessed once. Similarly, after the 1:1000 challenge, TNF alpha production by PBMC harvested from the blood compartment was 160 +/- 0, 160 +/- 0, and 213 +/- 22 pg, respectively, for new dialyzers, dialyzers reprocessed once, and dialyzers reprocessed 20 times (P = 0.008). After the 1:100 challenge, TNF alpha production was 168 +/- 8, 188 +/- 20, and 225 +/- 32 pg, respectively, for new dialyzers, dialyzers reprocessed once, and dialyzers reprocessed 20 times (P = 0.20). These results demonstrate that reprocessing of high-flux polysulfone dialyzers with bleach increases the risk of reverse-transfer of bacterial products from contaminated dialysate, and this risk appears to increase with the number of reuses. Consequently, units that reprocess membranes with bleach and have suboptimal water quality might subject their patients to a higher risk of cytokine-related morbidity. 相似文献
64.
Marco Alberti Pierangelo Dell��Acqua Lu��s Moniz Pereira 《Annals of Mathematics and Artificial Intelligence》2011,62(3-4):161-186
Many applications (such as system and user monitoring, runtime verification, diagnosis, observation-based decision making, intention recognition) all require to detect the occurrence of an event in a system, which entails the ability to observe the system. Observation can be costly, so it makes sense to try and reduce the number of observations, without losing full certainty about the event??s actual occurrence. In this paper, we propose a formalization of this problem. We formally show that, whenever the event to be detected follows a discrete spatial or temporal pattern, then it is possible to reduce the number of observations. We discuss exact and approximate algorithms to solve the problem, and provide an experimental evaluation of them. We apply the resulting algorithms to verification of linear temporal logics formulæ. Finally, we discuss possible generalizations and extensions, and, in particular, how event detection can benefit from logic programming techniques. 相似文献
65.
This paper proposes a novel computer vision approach that processes video sequences of people walking and then recognises
those people by their gait. Human motion carries different information that can be analysed in various ways. The skeleton
carries motion information about human joints, and the silhouette carries information about boundary motion of the human body.
Moreover, binary and gray-level images contain different information about human movements. This work proposes to recover
these different kinds of information to interpret the global motion of the human body based on four different segmented image
models, using a fusion model to improve classification. Our proposed method considers the set of the segmented frames of each
individual as a distinct class and each frame as an object of this class. The methodology applies background extraction using
the Gaussian Mixture Model (GMM), a scale reduction based on the Wavelet Transform (WT) and feature extraction by Principal
Component Analysis (PCA). We propose four new schemas for motion information capture: the Silhouette-Gray-Wavelet model (SGW)
captures motion based on grey level variations; the Silhouette-Binary-Wavelet model (SBW) captures motion based on binary
information; the Silhouette–Edge-Binary model (SEW) captures motion based on edge information and the Silhouette Skeleton
Wavelet model (SSW) captures motion based on skeleton movement. The classification rates obtained separately from these four
different models are then merged using a new proposed fusion technique. The results suggest excellent performance in terms
of recognising people by their gait. 相似文献
66.
André Maués Brabo Pereira Marcos Aurélio Marques Noronha 《Engineering with Computers》2010,26(1):35-47
Most post-processors for boundary element (BE) analysis use an auxiliary domain mesh to display domain results, working against
the profitable modelling process of a pure boundary discretization. This paper introduces a novel visualization technique
which preserves the basic properties of the boundary element methods. The proposed algorithm does not require any domain discretization
and is based on the direct and automatic identification of isolines. Another critical aspect of the visualization of domain
results in BE analysis is the effort required to evaluate results in interior points. In order to tackle this issue, the present
article also provides a comparison between the performance of two different BE formulations (conventional and hybrid). In
addition, this paper presents an overview of the most common post-processing and visualization techniques in BE analysis,
such as the classical algorithms of scan line and the interpolation over a domain discretization. The results presented herein
show that the proposed algorithm offers a very high performance compared with other visualization procedures. 相似文献
67.
Most work on pattern mining focuses on simple data structures such as itemsets and sequences of itemsets. However, a lot of recent applications dealing with complex data like chemical compounds, protein structures, XML and Web log databases and social networks, require much more sophisticated data structures such as trees and graphs. In these contexts, interesting patterns involve not only frequent object values (labels) appearing in the graphs (or trees) but also frequent specific topologies found in these structures. Recently, several techniques for tree and graph mining have been proposed in the literature. In this paper, we focus on constraint-based tree pattern mining. We propose to use tree automata as a mechanism to specify user constraints over tree patterns. We present the algorithm CoBMiner which allows user constraints specified by a tree automata to be incorporated in the mining process. An extensive set of experiments executed over synthetic and real data (XML documents and Web usage logs) allows us to conclude that incorporating constraints during the mining process is far more effective than filtering the interesting patterns after the mining process. 相似文献
68.
Cândida M. Pereira Jorge A. Ambrósio Amílcar L. Ramalho 《Multibody System Dynamics》2010,24(3):303-324
To overcome the difficulty on building manually complex models of chain drives, this work proposes a comprehensive methodology to build multibody models of any general chain drive automatically from a minimal set of data. The proposed procedure also evaluates the initial positions and velocities of all components of the drive that are consistent with the kinematic joints or with the contact pairs used in the model. In this methodology, all links and sprockets are represented by rigid bodies connected to each other either by ideal or by clearance revolute joints. The clearance revolute joint contact is further extended to handle the contact between the chain rollers and the sprocket teeth exact profiles. A suitable cylindrical continuous contact law is applied to describe the interaction on all contact pairs. One of the complexities of the computational study of roller chain drives is the large number of bodies in the system and the dynamics of the successive engagement and disengagement of the rollers with the sprockets. Each time a roller engages or disengages with a sprocket tooth, the number of rigid bodies in contact changes. The search for the contact pairs is recognized as one of the most time consuming task in contact analysis. This work proposes a procedure to specify the contact pairs and their update during the dynamic analysis optimizing the computational efficiency of the contact search. The methodologies adopted result in a general computer program that is applied and demonstrated in a generic chain drive that can be used in industrial machines, vehicle engines or any other type of mechanical system. 相似文献
69.
Bruno R. de Araújo Tiago Guerreiro Manuel J. Fonseca Joaquim A. Jorge João M. Pereira Monica Bordegoni Francesco Ferrise Mario Covarrubias Michele Antolini 《Journal of Real-Time Image Processing》2010,5(2):73-90
Currently, the design of aesthetic products is a process that requires a set of activities where digital models and physical
mockups play a key role. Typically, these are modified (and built) several times before reaching the desired design, increasing
the development time and, consequently, the final product cost. In this paper, we present an innovative design environment
for computer-aided design (CAD) surface analysis. Our system relies on a direct visuo-haptic display system, which enables
users to visualize models using a stereoscopic view, and allows the evaluation of sectional curves using touch. Profile curves
are rendered using an haptic device that deforms a plastic strip, thanks to a set of actuators, to reproduce the curvature
of the shape co-located with the virtual model. By touching the strip, users are able to evaluate shape characteristics, such
as curvature or discontinuities (rendered using sound), and to assess the surface quality. We believe that future computer-aided
systems (CAS)/CAD systems based on our approach will contribute in improving the design process at industrial level. Moreover,
these will allow companies to reduce the product development time by reducing the number of physical mockups necessary for
the product design evaluation and by increasing the quality of the final product, allowing a wider exploration and comparative
evaluation of alternatives in the given time. 相似文献
70.
This study investigated the short-term effects of daily recovery, that is, impaired psychological detachment from work and various actigraphical indicators of sleep quality, on near-accidents when commuting to work the next morning. Furthermore, the mediating effect of actigraphically assessed sleep quality on the relationship between impaired psychological detachment from work and near-accidents when commuting to work was analysed. Fifty-six full-time employees of a Swiss assurance company participated in the one-week study. Multilevel analyses revealed that impaired detachment was highly related to a decrease in sleep duration. Furthermore, impaired daily recovery processes, such as impaired psychological detachment from work and disturbed sleep quality, were related to commuting near-accidents. Impaired sleep quality mediated the effect of impaired psychological detachment from work on these near-accidents. Our results show that occupational safety interventions should address both impaired psychological detachment from work and sleep quality in order to prevent near accidents when commuting to work.
Practitioner Summary: Commuting accidents occur frequently and have detrimental effects on employees, organisations and society. This study shows that daily lack of recovery, that is, impaired psychological detachment and impaired sleep quality, is related to near-accidents when commuting to work the next morning. Primary prevention of commuting accidents should therefore address daily lack of recovery. 相似文献