Aqueous polymerization of methyl methacrylate initiated by ceric ion reducing agent systems in sulfuric acid medium

Polymerization of methyl methacrylate (MMA) was carried out in aqueous sulfuric acid medium at 30°C using ammonium ceric sulfate (ACS)/methyl ethyl ketone (MEK) and ammonium ceric sulfate/acetone as redox initiator systems. A short induction period was observed with both the initiator systems, as well as the attainment of limiting conversion for polymerization reactions. The rate of ceric ion consumption, R_ce, was first order with respect to Ce(IV) concentration in the concentration range (0.5–5.5) × 10⁻³M, and 0.5 order with respect to reducing agent concentration in the concentration ranges (0.0480–0.2967M) and (0.05–0.3912M) for Ce(IV)–MEK and Ce(IV)–acetone initiator systems, respectively. A fall in R_ce was observed at higher reducing agent concentrations. The plots of R_ce versus reducing agent concentrations raised to the half power yielded straight lines passing through the origin, indicating the absence of complex formation between reducing agents and Ce(IV). The addition of sodium sulfate to maintain constant sulfate ion concentration in the reaction medium could bring down the R_ce values in the present reaction systems. The rate of polymerization of MMA, R_p, increased with increase in Ce(IV), reducing agent, and monomer concentrations for the Ce(IV)–MEK initiator. The rate of polymerization of MMA is independent of Ce(IV) concentration and increased with an increase in reducing agent and monomer concentrations for the Ce(IV)–acetone initiator. At higher concentrations of reducing agent (0.4–0.5M), a steep fall in R_p values was observed with both the initiator systems. The orders with respect to Ce(IV), MEK, and MMA using the Ce(IV)–MEK initiator were found to be 0.23, 0.2, and 1.29, respectively. The orders with respect to Ce(IV), acetone, and MMA using the Ce(IV)–acetone initiator were found to be zero, 0.42, and 1.64, respectively. Maintaining constant [SO²⁻₄] in the reaction medium could bring down R_p values for the Ce(IV)–MEK initiator system. On the other hand, a rise in R_p values with an increase in [Na₂SO₄] could be observed when constant [SO²⁻₄] was maintained in the reaction medium for the Ce(IV) on reducing agent, production of radicals, initiation, propagation, and termination of the polymeric radicals by bimolecular interaction is proposed. An oxidative termination of primary radicals by Ce(IV) is also included. © 1996 John Wiley & Sons, Inc.     

Facilitating mobility for psychologists: Comparisons with and lessons from other health care professions.

Psychology and other health care professions are giving increasing attention to facilitating the movement of practitioners across jurisdictions. One of the greatest deterrents to mobility is the variability in licensing requirements among states and provinces. We review the status of mobility systems for licensed members of the professions of psychology, optometry, dentistry, medicine, nursing, and pharmacy. Each profession has, at a minimum, addressed the issue of mobility and licensure. With the exception of medicine, each profession currently has in place a version of licensure by endorsement and/or by reciprocity, although the professions differ in breadth of use and user-friendliness. Implications for enhancing mobility for psychologists are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social desirability ratings from males and females: A sexual item pool.

Administered the male and female forms of Thorne's Sex Inventory to 2 groups of 80 undergraduates who either rated the social desirability of a true response to each item or answered the items according to standard self-report instructions. Findings question the use of obvious-direct items with pathological import in sex behavior questionnaires. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On designing optimal parallel triangular solvers

This paper explores the problem of solving triangular linear systems on parallel distributed-memory machines. Working within the LogP model, tight asymptotic bounds for solving these systems using forward/backward substitution are presented. Specifically, lower bounds on execution time independent of the data layout, lower bounds for data layouts in which the number of data items per processor is bounded, and lower bounds for specific data layouts commonly used in designing parallel algorithms for this problem are presented in this paper. Furthermore, algorithms are provided which have running times within a constant factor of the lower bounds described. One interesting result is that the popular two-dimensional block matrix layout necessarily results in significantly longer running times than simpler one-dimensional schemes. Finally, a generalization of the lower bounds to banded triangular linear systems is presented.     

A comparative study of different approaches using an outranking relation in a multi-objective evolutionary algorithm

This paper presents a comparative analysis of three versions of an evolutionary algorithm in which the decision maker's preferences are incorporated using an outranking relation and preference parameters associated with the ELECTRE TRI method. The aim is using the preference information supplied by the decision maker to guide the search process to the regions where solutions more in accordance with his/her preferences are located, thus narrowing the scope of the search and reducing the computational effort. An example dealing with a pertinent problem in electrical distribution network is used to compare the different versions of the algorithm and illustrate how meaningful information can be elicited from a decision maker and used in the operational framework of an evolutionary algorithm to provide decision support in real-world problems.     

Effects of ultrasound on structural and physical properties of soy protein isolate (SPI) dispersions

The effects of low-frequency (20 kHz) ultrasonication at varying power (200, 400 or 600 W) and time (15 or 30 min) on functional and structural properties of reconstituted soy protein isolate (SPI) dispersions were examined. Ultrasonic treatments reduced both the storage modulus and loss modulus of SPI dispersions and formed more viscous SPI dispersions (fluid character). Moreover, ultrasound treatment significantly decreased the consistency coefficients and increased the flow behaviour index of SPI dispersions. Scanning electron microscopy of lyophilized ultrasonicated SPI showed different microstructure with larger aggregates compared to non-treated SPI. No significant change was observed in the protein electrophoretic patterns by SDS-PAGE. However, free sulfhydryl content, surface hydrophobicity and protein solubility of SPI dispersions were all increased with ultrasonic treatment. Differences in solubility profiles in the presence versus absence of denaturing (0.5% sodium dodecyl sulphate and 6 M urea) and reducing (mercaptoethanol) agents suggested a decrease in non-covalent interactions of SPI in dispersion after ultrasonic treatment. Secondary structure analysis by circular dichroism indicated lower α-helix and random coil in SPI treated at lower power, in contrast to higher α-helix and lower β-sheet in SPI treated with higher power (600 W). In conclusion, under the conditions investigated in this study, ultrasonic treatment resulted in partial unfolding and reduction of intermolecular interactions as demonstrated by increases in free sulfhydryl groups and surface hydrophobicity, leading to improved solubility and fluid character of SPI dispersions, while larger aggregates of ultrasonic-treated SPI in the dry state were formed after lyophilization.     

Interactions between aroma compounds and β-lactoglobulin in the heat-induced molten globule state

The present study aims to elucidate the binding of small hydrophobic ligands onto the molten globule state of β-lactoglobulin (BLG). The conversion of the native BLG into a molten globule state was induced by heat treatment at acidic pH. The molten globule state was evidenced by far and near-UV circular dichroism spectra. β-Ionone and guaiacol exhibited a higher binding ability to BLG in the heat-induced molten globule state compared to unheated BLG, as assessed by protein surface hydrophobicity measurements, using 6-propionyl-2-(dimethylamino)naphthalene (PRODAN) fluorescent probe. The binding sites of the two aroma compounds were determined by 2D nuclear magnetic resonance (NMR) spectroscopy. The less tightly packed structure of the molten globule favoured ligand binding, in particular within the central cavity. The greater flexibility of the calyx entrance, and the conformational change of loop EF induced an easier access of the central cavity after the thermal treatment.     

核心筒、隔断和无用空间

迫于日益增加的合作全球化和文化多样性．偏建设计工作室认为需要创造一种新的设计方法才能处理复杂交错的地理、文化和功能。通过几则彼此迥异却相互交织的故事——建筑核心筒、隔断和无用空间及其功能与空间的关联性．建筑师尝试在全球有关普遍性论述的范畴中揭示这些离散的空间的意义。     

Peptide Array on Cellulose Support—A Screening Tool to Identify Peptides with Dipeptidyl-Peptidase IV Inhibitory Activity within the Sequence of α-Lactalbumin

The inhibition of the enzyme dipeptidyl-peptidase IV (DPP-IV) is an effective pharmacotherapeutic approach for the management of type 2 diabetes. Recent findings have suggested that dietary proteins, including bovine α-lactalbumin, could be precursors of peptides able to inhibit DPP-IV. However, information on the location of active peptide sequences within the proteins is far from being comprehensive. Moreover, the traditional approach to identify bioactive peptides from foods can be tedious and long. Therefore, the objective of this study was to use peptide arrays to screen α-lactalbumin-derived peptides for their interaction with DPP-IV. Deca-peptides spanning the entire α-lactalbumin sequence, with a frame shift of 1 amino acid between successive sequences, were synthesized on cellulose membranes using “SPOT” technology, and their binding to and inhibition of DPP-IV was studied. Among the 114 α-lactalbumin-derived decamers investigated, the peptides ⁶⁰WCKDDQNPHS⁶⁹ (αK_i = 76 µM), ¹⁰⁵LAHKALCSEK¹¹⁴ (K_i = 217 µM) and ¹¹⁰LCSEKLDQWL¹¹⁹ (K_i = 217 µM) were among the strongest DPP-IV inhibitors. While the SPOT- and traditionally-synthesized peptides showed consistent trends in DPP-IV inhibitory activity, the cellulose-bound peptides’ binding behavior was not correlated to their ability to inhibit the enzyme. This research showed, for the first time, that peptide arrays are useful screening tools to identify DPP-IV inhibitory peptides from dietary proteins.