多分量数据全波形反演在气藏检测中的关键问题——以苏里格气田为例

苏里格气田是中国典型的致密砂岩气藏，构造简单、平缓，横向非均质性强，有效储层与围岩声学特征差别小，地震响应不明显，常规地震监测方法预测难度大，但气田含气砂岩泊松比低，是地震气藏检测的有效参数。利用弹性全波形反演精度高和能处理复杂非均质介质的优势，反演地层拉梅常数、剪切模量和密度，并计算泊松比，从而进行气藏预测。重点阐述了苏里格气田多分量数据全波形反演初始模型建模、先验模型建模和地震数据预处理3个关键问题的处理方法。二维三分量数据反演和"甜点"预测结果表明：①对于具有强非均质性的苏里格气田，利用全波形反演获得精度较高的地层弹性参数能显著提高气藏预测的准确度；②苏里格地区构造简单、平缓，利用常规叠加速度并结合构造解释可以建立比较好的初始模型，从而有效地解决了周波跳跃和局部极小的难题；③先验知识的约束和地震数据的预处理是全波形反演成功应用于苏里格气田气藏检测的关键。     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

黄陵矿区主要含水层特征对煤矿采掘的影响

黄陵矿区位于黄陇侏罗纪煤田北部,主要开采2#煤层,矿井生产中对各含水层特征认识不一,严重影响了煤矿的安全生产。针对此问题,收集整理黄陵矿区历年来的勘查数据,对各地层含水性特征进行客观分析与研究,并对主要含水层的富水性进行详细论述。研究结果表明,影响矿区煤层采掘的主要含水层为白垩系下统洛河组含水层和侏罗系中统直罗组含水层,其中,洛河组含水层对矿井采掘的影响较为突出。洛河组含水层富水性属于弱-中等,弱富水性区域位于矿区的东部,中等富水性区域位于矿区的中西部。今后矿井防治水工作中需高度重视矿区中西部洛河组含水层对煤矿采掘的影响。     

电磁精细探测法在隐伏型导水地质裂缝勘探中的应用

针对传统隐伏型导水地质裂缝勘探方法存在勘测精度较差的问题,提出电磁精细探测法探析隐伏型导水地质裂缝。依照屏蔽系数、实测场强和理论场强数据绘制综合曲线图,通过该图获取隐伏型导水地质裂缝所处位置几何阴影范围,采用层析成像法得到网格化的工作面,获取隐伏型导水地质图像。通过图像直接观测隐伏型导水地质工作面裂缝所处位置,在此基础上,观测四个电磁场分量,采用正交电磁场分量计算介质视电阻率,依据计算视电阻率数值和视电阻率分布状态研究裂缝发育情况和裂缝富水程度。结果表明:采用该方法能较为精准地获取隐伏型导水地质裂缝位置。通过裂缝位置进一步检测出隐伏型导水地质裂缝最大发育高度为63.5 m。当视电阻数值不断增加时,隐伏型导水地质裂缝和裂缝富水性逐渐减小,与实际情况较为相符,说明该种方法探析效果较好。     

Regulation of sensory nerve conduction velocity of human bodies responding to annual temperature variations in natural environments

The extensive research interests in environmental temperature can be linked to human productivity / performance as well as comfort and health; while the mechanisms of physiological indices responding to temperature variations remain incompletely understood. This study adopted a physiological sensory nerve conduction velocity (SCV) as a temperature‐sensitive biomarker to explore the thermoregulatory mechanisms of human responding to annual temperatures. The measurements of subjects’ SCV (over 600 samples) were conducted in a naturally ventilated environment over all four seasons. The results showed a positive correlation between SCV and annual temperatures and a Boltzmann model was adopted to depict the S‐shaped trend of SCV with operative temperatures from 5°C to 40°C. The SCV increased linearly with operative temperatures from 14.28°C to 20.5°C and responded sensitively for 10.19°C‐24.59°C, while tended to be stable beyond that. The subjects’ thermal sensations were linearly related to SCV, elaborating the relation between human physiological regulations and subjective thermal perception variations. The findings reveal the body SCV regulatory characteristics in different operative temperature intervals, thereby giving a deeper insight into human autonomic thermoregulation and benefiting for built environment designs, meantime minimizing the temperature‐invoked risks to human health and well‐being.     

Effect of CuSO4 on the Hydromechanical Behavior of Compacted Tailings

Laboratory tests, including compressibility, permeability, and microstructure tests, were conducted on tailings samples using custom-designed test apparatus to investigate the effect of metal contamination (Cu²⁺) on the hydromechanical behavior of compacted tailings. Infiltrating samples with various dry densities with distilled water or CuSO₄ solution at various concentrations showed that the void ratio of compacted tailings decreased with increased dry density. An increase in the metal contaminant concentrations from 0 to 0.1 mol/L increased the compression coefficient of the tailings from 0.14 to 0.84 MPa^?1 under a vertical load of 0.01 to 2.0 MPa, while the yield stress of the tailings decreased from 204.3 to 98.7 kPa, respectively. The linear relationship between permeability coefficient (k) and void ratio (e) is described by k?=???6.48?+?17.17e. Microstructure test results showed that the diffusion double layer thinned, and the surface potential decreased, indicating that the contaminant of Cu²⁺ enhanced the compressibility and permeability of the tailings. The microstructure test results also showed that the amount of fine-grained soil in the copper tailings was significantly less after the hydromechanical test. Therefore, the permeability and compressibility of copper tailings increased. The experimental results are in good agreement with the estimated results.

     

Visual Detection of Adenosine Triphosphate by Taylor Rising: A Simple Point-of-Care Testing Method Based on Rolling Circle Amplification

Rapid and sensitive point-of-care testing (POCT) is an extremely critical mission in practical applications, especially for rigorous military medicine, home health care, and in the third world. Here, we report a visual POCT method for adenosine triphosphate (ATP) detection based on Taylor rising in the corner of quadratic geometries between two rod surfaces. We discuss the principle of Taylor rising, demonstrating that it is significantly influenced by contact angle, surface tension, and density of the sample, which are controlled by ATP-dependent rolling circle amplification (RCA). In the presence of ATP, RCA reaction effectively suppresses Taylor-rising behavior, due to the increased contact angle, density, and decreased surface tension. Without addition of ATP, untriggered RCA reaction is favorable for Taylor rising, resulting in a significant height. With this proposed method, visual sensitive detection of ATP without the aid of other instruments is realized with only a 5 μL droplet, which has good selectivity and a low detection limit (17 nM). Importantly, this visual method provides a promising POCT tool for user-friendly molecular diagnostics.     

Study of MW-scale biogas-fed SOFC-WGS-TSA-PEMFC hybrid power technology as distributed energy system: Thermodynamic,exergetic and thermo-economic evaluation

Advanced biogas power generation technology has been attracting attentions, which contributes to the waste disposal and the mitigation of greenhouse gas emissions. This work proposes and models a novel biogas-fed hybrid power generation system consisting of solid oxide fuel cell, water gas shift reaction, thermal swing adsorption and proton exchange membrane fuel cell (SOFC-WGS-TSA-PEMFC). The thermodynamic, exergetic, and thermo-economic analyses of this hybrid system for power generation were conducted to comprehensively evaluate its performance. It was found that the novel biogas-fed hybrid system has a gross energy conversion efficiency of 68.63% and exergy efficiency of 65.36%, indicating high efficiency for this kind of hybrid power technology. The market sensitivity analysis showed that the hybrid system also has a low sensitivity to market price fluctuation. Under the current subsidy level for the distributed biogas power plant, the levelized cost of energy can be lowered to 0.02942 $/kWh for a 1 MW scale system. Accordingly, the payback period and annual return on investment can reach 1.4 year and about 20%, respectively. These results reveal that the proposed hybrid system is promising and economically feasible as a distributed power plant, especially for the small power scale (no more than 2 MW).