The impact of orthokeratology lens wear on binocular vision and accommodation: A short-term prospective study

Purpose

To investigate the effects of short-term orthokeratology (OK) on accommodation and binocular visual function in young adults.

Artificial neural network simulation of hourly groundwater levels in a coastal aquifer system of the Venice lagoon

Artificial Neural Networks (ANNs) have been successfully employed for predicting and forecasting groundwater levels up to some time steps ahead. In this paper, we present an application of feed forward neural networks (FFNs) for long period simulations of hourly groundwater levels in a coastal unconfined aquifer sited in the Lagoon of Venice, Italy. After initialising the model with groundwater elevations observed at a given time, the developed FNN should able to reproduce water level variations using only the external input variables, which have been identified as rainfall and evapotranspiration. To achieve this purpose, the models are first calibrated on a training dataset to perform 1-h ahead predictions of future groundwater levels using past observed groundwater levels and external inputs. Simulations are then produced on another data set by iteratively feeding back the predicted groundwater levels, along with real external data. The results show that the developed FNN can accurately reproduce groundwater depths of the shallow aquifer for several months. The study suggests that such network can be used as a viable alternative to physical-based models to simulate the responses of the aquifer under plausible future scenarios or to reconstruct long periods of missing observations provided past data for the influencing variables is available.     

Composite panels for reducing noise in air conditioning and ventilation systems

The plate silencer [1] that consists of an expansion chamber with two side-branch cavities covered by a light panel can achieve a desirable noise reduction in broadband theoretically. The concept is similar to drum silencer [Choy YS, Huang L. Experimental studies of drum-like silencer. J Acoust Soc Am 2002;112:2026–35]. To attain optimal noise reduction, either the membrane of the silencer should be of minimal weight while retaining very high tensile strength or the panel should be kept at very high bending stiffness that is dependent on its geometry and mechanical properties. To achieve such goal, various kinds of composite system such as carbon fibres or aluminum were mounted on light core foam to build a noise reflection panel. A design of composite panels which can provide a reduction in panel weight as well as enhance the bending stiffness, is introduced in this paper. Predictions of the new model are to be compared with the normal foam plate in the aspects of noise reflection capability and performance of noise abatement apart from the material properties.     

Performance Analysis of Split-Winding Doubly Salient Permanent Magnet Motor for Wide Speed Operation

In this paper, various flux-weakening techniques available for wide speed operation of the doubly salient permanent magnet (DSPM) motor are reviewed. A new split-winding topology capable of widening the speed range is proposed, which is valid not only for the DSPM motor with stationary PMs, but also for that with rotary PMs. Based on the parameters obtained by finite element analysis, the performance of the proposed DSPM motor is analyzed. The results show that this motor combines the features of wide speed range, high efficiency, simple structure, and low cost.     

Tamoxifen downregulates TGF-beta production in keloid fibroblasts

BACKGROUND: It has recently been suggested that primary lactase deficiency might have been selected for by malaria, as occurred for beta-thalassaemia and glucose 6-phosphate dehydrogenase deficiency. However, recently we have found that the prevalence of primary lactase deficiency in the area of Sassari (Northern Sardinia), where, in the past, there was intermediate malarial endemicity, is comparable to that observed in the adult population from other areas of Southern Italy where malaria was less endemic. AIMS: To address the problem further, we have determined the prevalence of primary lactase deficiency, glucose 6-phosphate dehydrogenase deficiency deficiency and beta-thalassaemia trait in the populations of three Sardinian villages which differ in altitude above sea-level, socioeconomic features, history of endemic malaria and prevalence of b-thalassaemia and glucose 6-phosphate dehydrogenase deficiency. SUBJECTS: We tested 138 adult males: 53 were from Fonni (a non-malarial mountain village, with a strong pastoral tradition), 38 from Lodé (a village with a similar pastoral tradition, but high malarial endemicity in the past) and 47 from Terralba (a lowland fishing village with an agricultural tradition and heavy malarial morbidity and mortality). METHODS: A blood sample was obtained in all subjects for determination of HbA2 and glucose 6-phosphate dehydrogenase activity. Lactase deficiency was assessed by measuring breath hydrogen production after oral administration of lactose (50 g), by gas-chromatography. RESULTS: The frequencies of glucose 6-phosphate dehydrogenase deficiency and of beta-thalassaemia trait in the non-malarial village of Fonni were strikingly low, compared to frequencies found in the two villages (Terralba and Lodé) with a very high past malarial morbidity. In contrast, there was no significant difference in the prevalence of lactase deficiency in the three groups of subjects from the three villages. CONCLUSIONS: These data obtained in Northern Sardinia do not support the hypothesis of a selection of primary lactase deficiency by malaria. For definitive conclusions, however, the malaria hypothesis should be tested in other parts of the world.     

Epidemiology of clonorchiasis in Ninh Binh Province, Vietnam

We present the spatial structure of binase, a small extracellular ribonuclease, derived from 1H-NMR* data in aqueous solution. The total of 20 structures were obtained via torsion angle dynamics using DYANA program with experimental NOE and hydrogen bond distance constraints and phi and chi1 dihedral angle constraints. The final structures were energy minimised with ECEPP/2 potential in FANTOM program. Binase consists of three alpha-helices in N-terminal part (residues 6-16, 26-32 and 41-44), five-stranded antiparallel beta-sheet in C-terminal part (residues 51-55, 70-75, 86-90, 94-99 and 104-108) and two-stranded parallel beta-sheet (residues 22-24 and 49-51). Three loops (residues 36-39, 56-67 and 76-83), which play significant role in biological functioning of binase, are flexible in solution. The differences between binase and barnase spatial structures in solution explain the differences in thermostability of binase, barnase and their hybrids.     

Effects of intrathecal alpha1- and alpha2-noradrenergic agonists and norepinephrine on locomotion in chronic spinal cats

Noradrenergic drugs, acting on alpha adrenoceptors, have been found to play an important role in the initiation and modulation of locomotor pattern in adult cats after spinal cord transection. There are at least two subtypes of alpha adrenoceptors, alpha1 and alpha2 adrenoceptors. The aim of this study was to investigate the effects of selective alpha1 and alpha2 agonists in the initiation and modulation of locomotion in adult chronic cats in the early and late stages after complete transection at T13. Five cats, chronically implanted with an intrathecal cannula and electromyographic (EMG) electrodes were used in this study. Noradrenergic drugs including alpha2 agonists (clonidine, tizanidine, and oxymetazoline) and an antagonist, yohimbine, one alpha1 agonist (methoxamine), and a blocker, prazosin, as well as norepinephrine were injected intrathecally. EMG activity synchronized to video images of the hindlimbs were recorded before and after each drug injection. The results show differential effects of alpha1 and alpha2 agonists in the initiation of locomotion in early spinal cats (i.e., in the first week or so when there is no spontaneous locomotion) and in the modulation of locomotion and cutaneous reflexes in the late-spinal cats (i.e., when cats have recovered spontaneous locomotion). In early spinal cats, all three alpha2 agonists were found to initiate locomotion, although their action had a different time course. The alpha1 agonist methoxamine induced bouts of nice locomotor activity in three spinal cats some hours after injection but only induced sustained locomotion in one cat in which the effects were blocked by the alpha1 antagonist prazosin. In late spinal cats, although alpha2 agonists markedly increased the cycle duration and flexor muscle burst duration and decreased the weight support or extensor activity (effects blocked by an alpha2 antagonist, yohimbine), alpha1 agonist increased the weight support and primarily the extensor activity of the hindlimbs without markedly changing the timing of the step cycle. Although alpha2 agonists, especially clonidine, markedly reduced the cutaneous excitability and augmented the foot drag, the alpha1 agonist was found to increase the cutaneous reflex excitability. This is in line with previously reported differential effects of activation of the two receptors on motoneuron excitability and reflex transmission. Noradrenaline, the neurotransmitter itself, increased the cycle duration and at the same time retained the cutaneous excitability, thus exerting both alpha1 and alpha2 effects. This work therefore suggests that different subclasses of noradrenergic drugs could be used to more specifically target aspects of locomotor deficits in patients after spinal injury or diseases.     

Generalized nonlinear FET/HEMT modeling

A modeling procedure which provides an accurate large-signal response for variation in bias, input power level, and fundamental frequency for FET/HEMT transistors is designed. A procedure for measuring the large-signal input response on an easily implemented system is presented. The technique is illustrated by designing a nonlinear PHEMT model, which includes an accurate large-signal input response and works with variations in the aforementioned input conditions. © 2004 Wiley Periodicals, Inc. Int J RF and Microwave CAE 14, 122–133, 2004.