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51.
Weigang Liang Beibei Wang Guofeng Shen Suzhen Cao Bertrand Mcswain Ning Qin Liyun Zhao Dongmei Yu Jicheng Gong Shanshan Zhao Yawei Zhang Xiaoli Duan 《Indoor air》2020,30(2):264-274
Stunting adversely affects physical and mental outcomes of children. It has not been examined whether household air pollution from solid fuel combustion is a risk factor for stunting in children. In a total of 41,439 children aged 6-17 across China, height was measured using a unified protocol. Multivariable linear regression models and logistic regression models were used to assess the associations of solid fuel use for cooking/heating with stunting in children. Adjusted for covariates, cooking/heating with solid fuel was significantly associated with a lower z-score for height for age and sex (β = −0.21 [−0.32 to −0.09] and −0.17 [−0.31 to −0.03], respectively) and an increased risk of stunting with an estimated ORs of 1.34 [1.07~1.68] and 1.37 [1.02~1.83], respectively. The risk of stunting associated with solid fuel use was statistically significant in high-age children. And the effect was greater on girls than on boys, though the difference was not statistically significant. Our study suggested that Chinese children living in households using solid fuel had a significantly higher risk of stunting than those living in households using cleaner fuel. 相似文献
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Zu Guoqing Lu Yukuan Yan Yi Zhang Xiaoming Zhao Jingwei Du Wei Ran Xu Jiang Zhengyi 《Metals and Materials International》2020,26(2):248-259
Metals and Materials International - The flow behaviour and microstructure characteristics of a ferritic stainless steel were investigated using plain strain compression test on a Gleeble 3500... 相似文献
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Dr. Blijke S. Kroezen Gabriele Conti Benedetta Girardi Dr. Jonathan Cramer Dr. Xiaohua Jiang Dr. Said Rabbani Jennifer Müller Maja Kokot Enrico Luisoni Prof. Daniel Ricklin Dr. Oliver Schwardt Prof. Beat Ernst 《ChemMedChem》2020,15(18):1706-1719
Siglecs are members of the immunoglobulin gene family containing sialic acid binding N-terminal domains. Among them, Siglec-8 is expressed on various cell types of the immune system such as eosinophils, mast cells and weakly on basophils. Cross-linking of Siglec-8 with monoclonal antibodies triggers apoptosis in eosinophils and inhibits degranulation of mast cells, making Siglec-8 a promising target for the treatment of eosinophil- and mast cell-associated diseases such as asthma. The tetrasaccharide 6’-sulfo-sialyl Lewisx has been identified as a specific Siglec-8 ligand in glycan array screening. Here, we describe an extended study enlightening the pharmacophores of 6’-sulfo-sialyl Lewisx and the successful development of a high-affinity mimetic. Retaining the neuraminic acid core, the introduction of a carbocyclic mimetic of the Gal moiety and a sulfonamide substituent in the 9-position gave a 20-fold improved binding affinity. Finally, the residence time, which usually is the Achilles tendon of carbohydrate/lectin interactions, could be improved. 相似文献
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针对换热网络多目标优化问题,采用目前应用较广泛的两种多目标遗传算法,即NSGA-Ⅱ和NSGA-Ⅲ,对两种算法的性能进行对比研究。案例研究结果表明,NSGA-Ⅱ算法比NSGA-Ⅲ算法运行效率更高,NSGA-Ⅲ的运行时间是NSGA-Ⅱ的2倍以上;NSGA-Ⅱ算法的应用并不严格地受限于3个目标的最大目标数量,NSGA-Ⅱ在求解大于3个目标的多目标优化问题时也可能具有良好的性能,目标数量并非选择NSGA-Ⅱ和NSGA-Ⅲ算法的严格标准。对10×5换热网络案例进行4个相关目标改造优化时,从换热网络的单一性能指标来看,NSGA-Ⅱ算法更容易获得各目标的极值。从最小年度总费用的评价指标来看,两种算法的最优方案效果相近。对7×3换热网络案例进行6个目标的优化时,NSGA-Ⅲ算法得到各目标的极值较优。从最小年度总费用的评价指标来看,NSGA-Ⅲ算法获得的投资费用和年度总费用更小。对于目标函数数量不超过3个,或者3个以上具有一定相关性的多目标优化问题,推荐优先使用NSGA-Ⅱ算法实现快速寻优;而NSGA-Ⅲ算法由于其基于参考点的选择机制,运行效率较慢,更适合用于收敛困难的高维多目标优化问题。 相似文献
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Mingchang Lin Yufei Zhang Guosong Chen Ming Jiang 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(45):6065-6070
Glyco‐mimicking nanoparticles (glyco‐NPs) with Förster resonance energy transfer (FRET) donor and acceptor groups formed via dynamic covalent bond of benzoboroxole and sugar from two complementary polymers are prepared. The glyco‐NPs are proved to be quite stable under physiological conditions but sensitive to pH. So the glyco‐NPs can be internalized by dendritic cells with integrity and nontoxicity and then dissociate within the acidic organelles. This particle dissociation is directly observed and visualized in vitro, for the first time via the FRET measurements and fluorescent microscopy. This feature makes controlled release of drug or protein by glyco‐NPs possible, i.e., when model antigen Ovalbumin is loaded in the glyco‐NPs, the released Ovalbumin in dendritic cells stimulates T cells more efficiently than the free Ovalbumin itself as a result of the enhanced antigen processing and presentation. Thus, the results enlighten a bright future of the glyco‐NPs in immunotherapy. 相似文献
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Functional expression and synergistic cooperation of xylan‐degrading enzymes from Hypocrea orientalis and Aspergillus niger 下载免费PDF全文
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