天然团聚岩土料滑坡堰塞体模型试验研究

滑坡堰塞坝主要形成于高山峡谷地区,在我国川西南地区尤为常见.掌握其形成过程和堆积特点有助于准确分析堰塞坝溃决风险、科学制定应急抢险措施,从而最大限度地降低灾害造成的生命财产损失.本文通过开展滑坡堵江室内物理模型试验,研究了堰塞坝的形成过程及坝体物质结构特点.试验采用不同物理性质的天然团聚土料作为堰塞体物源,记录了其在模拟滑槽中滑动、碰撞、解体、破碎及堵江堆积的全过程.同时,结合筛分试验和堰塞坝横断面图像分析,研究了坝体颗粒大小和空间分布特征.另外,分析了天然团聚土基本力学参数指标与堰塞坝体物质分布特征的关系,将坝体分为细粒区和粗粒区,并对其溃坝特征做出预测分析.     

Application of genetic algorithm-based intuitionistic fuzzy weighted c-ordered-means algorithm to cluster analysis

Knowledge and Information Systems - With the advance of information technology, many fields have begun using data clustering to reveal data structures and obtain useful information. Most of the...     

校园网络立体化数据存储方案的研究与设计

本文针对校园网络数据存储方式单一、成本高、实用性不高的问题,设计了一个实用、可操作性的立体化数据存储方案。该方案发挥raid、虚拟存储和数据容灾三种存储技术各自的优势,将这三种存储技术有机的融合,构建了三个存储层,物理存储层、虚拟存储层、数据容灾备份层,每个层又采取两种不同的存储方式,在实用、低廉的基础上实现数据的安全冗余和立体化备份,从而确保校园应用数据的安全性和可用性。     

Optimal Performance in Tracking Stochastic Signal Under Disturbance Rejection

The analysis method of optimal tracking performance is proposed for multiple‐input multiple‐output (MIMO) linear time‐invariant (LTI) systems under disturbance rejection. An H₂ criterion of the error signal between the output of the plant and the reference signal is used as a measure for the tracking performance. Spectral factorization is applied to obtain the optimal solution of the system tracking error. The explicit expressions are derived for this minimal tracking error with respect to random reference signals under disturbance rejection. It is shown that the nonminimum phase zeros, the zero direction, the unstable poles, the pole direction of a given plant, statistical characteristics of the reference input signal, and disturbance signal have a negative effect on a feedback system's ability to reduce the system error with disturbance rejection. The results show that the optimal tracking performance will further be damaged because of disturbance rejection. Some typical examples are given to illustrate the theoretical results.     

"冻结系数法"的改进

本文改进、推广了时变线性系统稳定性的"冻结系数法",使该法应用范围得以扩大.     

Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis

Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA H19 has been found to be overexpressed in several fibrosis diseases. Here, we examined the expression of H19 in OSF specimens and its functional role in fibrotic buccal mucosal fibroblasts (fBMFs). Our results indicate that the aberrantly overexpressed H19 contributed to higher myofibroblast activities, such as collagen gel contractility and migration ability. We also demonstrated that H19 interacted with miR-29b, which suppressed the direct binding of miR-29b to the 3′-untranslated region of type I collagen (COL1A1). We showed that ectopic expression of miR-29b ameliorated various myofibroblast phenotypes and the expression of α-smooth muscle actin (α-SMA), COL1A1, and fibronectin (FN1) in fBMFs. In OSF tissues, we found that the expression of miR-29b was downregulated and there was a negative correlation between miR-29b and these fibrosis markers. Lastly, we demonstrate that arecoline stimulated the upregulation of H19 through the transforming growth factor (TGF)-β pathway. Altogether, this study suggests that increased TGF-β secretion following areca nut chewing may induce the upregulation of H19, which serves as a natural sponge for miR-29b and impedes its antifibrotic effects.     

基于数字媒体技术的图像融合算法

图像融合技术是数字媒体技术中很重要的一个方向。图像融合因为其融合后可以保留相对较多的场景,融合后图像精度高,便于后续图像中目标观测和特征点的提取。研究一种基于数字媒体技术的图像融合算法,并与其它传统的图像融合算法进行了比较。     

Numerical investigation of water and temperature distributions in a proton exchange membrane electrolysis cell

Science China Technological Sciences - A three-dimensional, non-isothermal, two-phase model for a PEM water electrolysis cell (PEMEC) is established in this study. An effective connection between...     

Single-molecule biotechnology for protein researches

Cells employ proteins to perform metabolic functions and maintain active physiological state through charge transfer and energy conversion. These processes are carried out in a narrow space precisely and rapidly, which, no doubt, bring great difficulty for their detection and dissection. Fortunately, in recent years, the development and expansion of single-molecule technique in protein research make monitoring the dynamical changes of protein at single-molecule level a reality, which also provides a powerful tool for the further exploration of new phenomena and new mechanisms of life activities. This paper aims to summarize the working principle and essential achievements of single-molecule technique in protein research in recent five years. We focus on not only dissecting the difference of nanopores, atomic force microscope, scanning tunneling microscope, and optical tweezers technique, but also discussing the great significance of these single-molecule techniques in investigating intramolecular and intermolecular interactions, electron transport, and conformational changes. Finally, the opportunities and challenges of the single-molecule technique in protein research are discussed, which provide a new door for single-molecule protein research.