Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors

Antisense oligodeoxynucleotides were used to determine whether alterations in the expression of N-methyl-D-aspartate (NMDA) receptor subunit mRNA are responsible for developmental changes in the sensitivity of receptors to agonists and antagonists. Xenopus laevis oocytes were injected with mRNA prepared from neonatal and adult rat cerebral cortex, and the effects of agonists and antagonists were determined under voltage-clamp conditions. Glycine-site antagonists like 7-chlorokynurenate and glutamate-site antagonists like CGP-39653 were more potent at NMDA receptors expressed from mRNA from adult rat cerebral cortex than those expressed from mRNA from 1-day-old rat. NMDA receptors from 1-day-old rat cerebral cortex were more sensitive to activation by glycine than were receptors from adult rat cerebral cortex. 7-Chlorokynurenate and CGP-39653 were more potent inhibitors of responses seen with heteromeric NR1/NR2A receptors than with NR1/ NR2B receptors. Conversely, heteromeric NR1/NR2B receptors were more sensitive to activation by glycine than were NR1/NR2A receptors. We previously described a delay in the expression of the NR2A subunit in developing rat brain. Anti-sense oligodeoxynucleotides were used to determine whether the delayed expression of the NR2A subunit underlies changes in pharmacological properties observed during development. The properties of receptors seen when adult brain mRNA was coinjected with antisense oligodeoxynucleotides against the NR2A subunit were similar to those found in receptors from 1-day-old rat brain. These data suggest that changes in the sensitivity of NMDA receptors to antagonists and to glycine seen during development are a result of alterations in the expression of different species of NR2 subunit mRNA.     

Finite twist and extension of a cylindrical elastic membrane

Summary We consider a circular cylindrical membrane subjected to longitudinal extension and twist. The associated equilibrium deformation is considered to be axisymmetric and the analysis is based on a direct two-dimensional formulation. Wrinkling of the membrane is taken into account in an approximate way by introducing arelaxed strain energy function derived from the neo-Hookean strain energy for isotropic elastic solids. Analytical formulae for wrinkled parts of the membrane are used to corroborate the results of a numerical treatment of the full boundary value problem.Dedicated to the memory of A. C. Pipkin     

离散动态系统及其应用（Ⅲ）─市场价格模型的数学分析

本文应用动力系统的定性分析方法，对离散市场价格模型作出全局分析，给出了关于离散市场价格系统的稳定性和分支结构的若干定理及其经济意义．     

数字式速度比例同步电脑控制系统

数字式速度比例同步控制系统，是把先进的交流变频调速技术，微电子技术和节能效果显著的永磁同步电机融为一体组成的性能优良的调速控制系统。该系统具有调速精度高调整范围大、稳定性好、抗干扰能力强、调整方便、节电效果显著等一系列优点。本文详细介绍了该系统的工作原理，并通过应用实例和分析对比，阐述该系统的优越性。     

稠油油藏的注汽量预测

利用HCZ预测模型，可对已开发油田的年产量和累计产量进行全程预测，并且在实际应用中取得了较好的预测结果。本文结合稠油田的实际情况，推导出HXZ预测模型在热采中注汽参数的预测公式。结合曙光油田曙1－7－5块的开发数据进行了预测，效果较好。     

重油催化裂化装置轴流风机的损坏与修复

广州分公司炼油厂重油催化裂化装置四机组轴流风机在 1998年 9月由于入口消音器故障引发重大事故 ,严重影响了装置生产。该文主要针对其损坏的原因、情况和修复方法作了探讨和论述     

乙醇电氧化的研究进展

简要地叙述了国内外乙醇电催化氧化的研究进展，着重介绍不同电极材料对乙醇电氧化的影响及目前所提山的机理，并对其可能的研究方向提出了建议。     

The use of doped polyaniline as an electrode in the galvanic anodic protection of ferrous metals in industrial acid solutions

In order to investigate the galvanic anodic protection (GAP) of ferrous metals (such as 410, 304 and 316 stainless steels) in acid solutions by doped polyaniline (PANi), separate doped PANi powder-pressed electrodes with different surface areas (the area ratio of the PANi electrode to stainless steel is between 1:1 and 1:2) have been prepared. These were coupled with ferrous metal in the following solutions: 5 M sulphuric acid, 5 M phosphoric acid and industrial phosphoric acid (containing 5 M phosphoric acid and 0.05% chloride ion) to construct a galvanic cell, in which PANi is cathode while ferrous metal is anode. The results indicate that a PANi electrode with sufficient area can provide corrosion protection to stainless steel in these acidic solutions. A pilot scale coupling experiment was carried out. The results indicate that PANi is a promising material as an electrode for the anodic protection of ferrous metals in acidic solutions in industrial situations.     

双螺杆反应挤出模型的研究

详细研究了双螺杆中反应挤出聚合物的动力学模型、流动模型和传热模型。通过实验得到了双螺杆反应器中聚合物的停留时间分布及平均停留时间。