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141.
A highly hydrophobic silica mesostructure was synthesized by a modification on the conventional co-condensation procedure that involved the partial substitution of hexadecytltrimethylammonium, used as mesostructure directing agent, by hexadecyltrimethoxysilane. That modification allowed the production of a highly ordered hexagonal silica mesostructure with the mesopores partially filled with high amounts of hexadecyl chains, covalently bonded to inorganic framework. After extracting the reminiscent template molecules, ibuprofen was loaded into the mesostructure in order to evaluate its drug release properties. The drug loading amount (21 wt%) was comparable to the one reported for MCM-41 with grafted propylamine groups (25 wt%), indicating that C16-chains were not fully compacted occluding the pores. A slow ibuprofen release was observed in simulated body fluid (pH 7.2) by a process controlled by an anomalous transport with contribution of diffusional and relaxational components, according to the Korsmeyer-Peppas kinetics model. That hydrophobic mesostructure produced has the potential of being use as a carrier for low water soluble drugs with an extended delivery effect, but without the disadvantages of co-releasing toxic surfactant molecules or the need of non-toxic specific templates to be prepared. 相似文献
142.
Alessandro Costa Pietro Massimino Marilena Bandieramonte Ugo Becciani Mel Krokos Costantino Pistagna Simone Riggi Eva Sciacca Fabio Vitello 《Journal of Grid Computing》2015,13(4):547-559
The Cherenkov Telescope Array (CTA) is currently building the next generation, ground-based, very high-energy gamma-ray instrumentation. CTA is expected to collect very large datasets (in the order of petabytes) which will have to be stored, managed and processed. This paper presents a graphical user interface built inside a science gateway aiming at providing CTA-users with a common working framework. The gateway is WS-PGRADE/gUSE workflow-oriented and is equipped with a flexible SSO (based on SAML) to control user access for authentication and authorization. An interactive desktop environment is provided, called Astronomical & Physics Cloud Interactive Desktop (ACID). Users are able to exploit the graphical interface as provided natively by the tools included in ACID. A cloud data service shares and synchronizes data files and output results between the user desktop and the science gateway. Our solution is a first attempt towards an ecosystem of new technologies with a high level of flexibility to suit present and future requirements of the CTA community. 相似文献
143.
Hayane Ferreira Leite Ladislau Thaísa Gabriela Silva de Farias Bruna Lúcia Mendonça Soares José Alberto da Costa Medeiros Natália Ferrão Castelo Branco Melo Thatiana Montenegro Stamford–Arnaud Thayza Christina Montenegro Stamford Tânia Lucia Montenegro Stamford 《International Journal of Food Science & Technology》2021,56(10):5395-5401
This research verified the ability of Lactobacillus rhamnosus encapsulated with inulin to tolerate the simulated digestive system and their viability in a soy blend. Probiotic encapsulated in alginate-chitosan matrix without inulin presented a better encapsulation efficiency (80.92%) than encapsulation with inulin (57.39%). On the 28th day, the count of probiotics decreased by 3.42 and 1.99 logarithmic cycles of free and encapsulated cells without inulin, respectively. In contrast, the microorganisms encapsulated with inulin showed an increase of 1.26 logs CFU g−1. During gastrointestinal simulation, cell counts decreased by 0.78, 1.55 and 1.95 CFU g−1 logs for encapsulated cells without inulin, free and encapsulated with inulin, respectively. Sensory panellists liked the fermented soy blend with encapsulated lactobacilli, and this result shows the possibility to create new probiotic foods of plant origin. Therefore, the alginate/chitosan matrix can be considered adequate for the encapsulation of L. rhamnosus. The inulin reduces the encapsulation efficiency and increases the cell loss in gastrointestinal simulation. Considering cellular losses, the best option for preparing a fermented soy blend is to use L. rhamnosus encapsulated without inulin. 相似文献
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A. Costa e Silva 《Journal of Phase Equilibria and Diffusion》2017,38(6):916-927
The steel industry is challenged to develop new and efficient alloys, from the application, energy and environmental points of view. Alternative materials, too, challenge steel in individual applications. The industry has successfully met these challenges in the last 150 years, at least. In the last decades, one of the tools that contributed to this success has been computational thermodynamics, an integral part of the expanding ICME toolbox. In this work, the important change in paradigm brought by computational thermodynamics to solving problems involving equilibrium in complex systems, as those present in the steel industry, is reviewed. Then, examples of applications to problems ranging from steelmaking to processing and alloy design are presented, highlighting the importance of multicomponent databases. The extension from equilibrium to kinetics is included in some examples. It is concluded that computational thermodynamics in the steel industry is mature and, while some limitations may persist in areas of kinetic modeling, these techniques will mature in the near future. 相似文献
147.
ABSTRACT: BACKGROUND: Food and nutritional care quality must be assessed and scored, so as to improve health institution efficacy. This study aimed to detect and compare actions related to food and nutritional care quality in public and private hospitals. METHODS: Investigation of the Hospital Food and Nutrition Service (HFNS) of 37 hospitals by means of structured interviews assessing two quality control corpora, namely nutritional care quality (NCQ) and hospital food service quality (FSQ). HFNS was also evaluated with respect to human resources per hospital bed and per produced meal. RESULTS: Comparison between public and private institutions revealed that there was a statistically significant difference between the number of hospital beds per HFNS staff member (p = 0.02) and per dietitian (p < 0.01). The mean compliance with NCQ criteria in public and private institutions was 51.8% and 41.6%, respectively. The percentage of public and private health institutions in conformity with FSQ criteria was 42.4% and 49.1%, respectively. Most of the actions comprising each corpus, NCQ and FSQ, varied considerably between the two types of institution. NCQ was positively influenced by hospital type (general) and presence of a clinical dietitian. FSQ was affected by institution size: large and medium-sized hospitals were significantly better than small ones. CONCLUSIONS: Food and nutritional care in hospital is still incipient, and actions concerning both nutritional care and food service take place on an irregular basis. It is clear that the design of food and nutritional care in hospital indicators is mandatory, and that guidelines for the development of actions as well as qualification and assessment of nutritional care are urgent. 相似文献
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Paulo H. R. Borges Neil B. Milestone Juliana O. Costa Cyril J. Lynsdale Túlio H. Panzera André L. Christophoro 《Materials and Structures》2012,45(5):663-678
Blended cement pastes are currently used for encapsulation of low level and intermediate level nuclear waste in the UK. However,
there is still little information on the long-term durability of those mixes to some chemical attacks. Accelerated testing
may predict the long-term durability or at least help the selection of more durable formulations. In this work, blended blastfurnace
slag (BFS)/Portland cement (OPC) pastes containing 60, 75 and 90% BFS and pulverised fuel ash (PFA)/OPC pastes with 40, 55
and 75% PFA were cured at 20 and 60°C for 90 days then submitted to natural and accelerated carbonation (5% CO2). The effects of the curing temperature as well as the OPC replacement level on the carbonation ratio are presented. Results
showed a good correlation between natural and accelerated carbonation for the pastes studied. Carbonation was found to be
governed by the amount of calcium hydroxide available in the mixes before the process started. 相似文献
150.