The role of lipoxygenase-isoforms in atherogenesis

Lipoxygenases (LOXs) form a heterogeneous family of lipid-peroxidizing enzymes, and several LOX-isoforms (12/15-LOX, 5-LOX) have been implicated in atherogenesis. However, the precise role of these enzymes is still a matter of discussion. 12/15-LOXs are capable of oxidizing lipoproteins (low-density lipoprotein (LDL), high-density lipoprotein (HDL)) to atherogenic forms, and functional inactivation of this enzyme in murine atherosclerosis models slows down lesion formation. In contrast, rabbits that overexpress this enzyme were protected from lesion formation when fed a lipid-rich diet. To contribute to this discussion, we recently investigated the impact of 12/15-LOX overexpression on in vitro foam cell formation. When 12/15-LOX-transfected J774 cells were incubated in culture with modified LDL, we found that intracellular lipid deposition was reduced in the transfected cells when compared with the corresponding control transfectants. This paper briefly summarizes the current status of knowledge on the biological activity of different LOX-isoforms in atherogenesis and will also provide novel experimental data characterizing the role of 12/15-LOX in cellular LDL modification and for in vitro foam cell formation.     

Zerstörungskinetik des technisch reinen Eisens bei Kavitationsbeanspruchung

Beschreibung einer Versuchseinrichtung zur Simulierung erosionsintensiver Kavitationsbeanspruchung. Veränderung des technisch reinen Eisens durch implodierende Kavitationsblasen während der Inkubationsperiode und im Spätstadium der Schädigung, Hinweise für Erhöhung des Kavitationswiderstandes.     

Methyl-nitrocatechols: atmospheric tracer compounds for biomass burning secondary organic aerosols

Detailed chemical analysis of wintertime PM?? collected at a rural village site in Germany showed the presence of a series of compounds that correlated very well with levoglucosan, a known biomass burning tracer compound. Nitrated aromatic compounds with molecular formula C?H?NO? (M(w) 169) correlated particularly well with levoglucosan, indicating that they originated from biomass burning as well. These compounds were identified as a series of methyl-nitrocatechol isomers (4-methyl-5-nitrocatechol, 3-methyl-5-nitrocatechol, and 3-methyl-6-nitrocatechol) based on the comparison of their chromatographic and mass spectrometric behaviors to those from reference compounds.Aerosol chamber experiments suggest that m-cresol, which is emitted from biomass burning at significant levels, is a precursor for the detected methyl-nitrocatechols. The total concentrations of these compounds in the wintertime PM??were as high as 29 ng m?3, indicating the secondary organic aerosol (SOA) originating from the oxidation of biomass burning VOCs contributed non-negligible amounts to the regional organic aerosol loading.     

Discovery of Riociguat (BAY 63‐2521): A Potent,Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

Direct stimulation of soluble guanylate cyclase (sGC) represents a promising therapeutic strategy for the treatment of a range of diseases, including the severely disabling pulmonary hypertension (PH). Optimization of the unfavorable DMPK profile of previous sGC stimulators provided riociguat, which is currently being investigated in phase III clinical trials for the oral treatment of PH.

     

Fiber Bragg Gratings in Small-Core Ge-Doped Photonic Crystal Fibers

This paper reports fiber Bragg gratings （FBGs） inscribed in a small-core Ge-doped photonic crystal fibers with a UV laser and a Talbot interferometer. The responses of such FBGs to temper- ature, strain, bending, and transverse-loading were systematically investigated. The Bragg wavelength of the FBGs shifts toward longer wavelengths with increasing temperature, tensile strain, and transverse-loading. The bending and transverse- loading properties of the FBGs are sensitive to the fiber orientations.