Although increasing evidence suggests a central mechanism of action for sacral neuromodulation, the exact mechanism remains unclear. We set up a scanning paradigm to measure brain activation related to various stages of rectal filling using rectal balloon distention.
Materials and Methods
Six healthy volunteers underwent rectal balloon distention during MRI scanning at a 1.5T scanner with a Tx/Rx head coil. MR images were collected at four levels of distention: empty balloon (EB), first sensation volume (FSV), desire to defecate volume (DDV), maximum tolerable volume (MTV). Data were analyzed using BrainVoyager 20.4. Whole brain and ROI-based fixed-effects general linear model analyses were performed on the fMRI time-course data from all participants.
Results
Rectal filling until FSV evoked the most blood-oxygen-level-dependent responses in several clusters throughout the cortex, followed by the responses evoked by rectal filling until DDV. Interestingly, rectal filling until MTV evoked negative responses compared to baseline throughout the cortex. No negative side effects were found.
Discussion
This study shows that a standardized paradigm for functional MRI combined with rectal filling is feasible and safe in healthy volunteers and is ready to be used in fecal incontinent patients to assess whether their brain activity differs from healthy controls.
We describe a method for resolving ambiguities in low-level disparity calculations in a stereo-vision scheme by using a recurrent
mechanism that we call signal-symbol loop. Due to the local nature of low-level processing it is not always possible to estimate
the correct disparity values produced at this level. Symbolic abstraction of the signal produces robust, high confidence,
multimodal image features which can be used to interpret the scene more accurately and therefore disambiguate low-level interpretations
by biasing the correct disparity. The fusion process is capable of producing more accurate dense disparity maps than the low-
and symbolic-level algorithms can produce independently. Therefore we describe an efficient fusion scheme that allows symbolic-
and low-level cues to complement each other, resulting in a more accurate and dense disparity representation of the scene. 相似文献
Carbon-based nanomaterials possess unique structural, mechanical, and electronic properties that are exploited in numerous applications. The fate of nanomaterials in living systems and in the environment is largely unknown, though there is a reason for concern. Here it is shown how the interaction of fullerene with natural phenolic acid induces cell contraction. This phenomenon has a general applicability to carbon-based nanomaterials interacting with natural amphiphiles. Atomistic simulations reveal that the self-assembly of C(70)-gallic acid (GA) favors aggregation. Confocal fluorescence microscopy shows that C(70)-GA complexes translocate across the membranes of HT-29 cells and enter nuclear membranes. Confocal imaging further reveals the real-time uptake of C(70)-GA and the consequent contraction of the cell membranes. This contraction is attributed to the aggregation of nanoparticles into microsized particles promoted by cell surfaces, a new physical mechanism for deciphering nanotoxicity. 相似文献
In our earlier work, we have proposed some modifications for the bandwidth broker framework. With our modifications, it is possible to use measurement-based admission control in addition to the more traditional parameter-based admission control. Moreover, we have presented a new flexible admission control scheme that has proven to be very efficient in terms of bottleneck link utilization. Two problems, however, have arisen: the use of scheduling weights in admission control and bursty connection arrivals. In this paper, we present that the former one can be dealt with the use of adaptive scheduling weights, while the latter one can be fought with adaptive reservation limits. The proposed new algorithms are validated through simulations and their performance is compared against the nonadaptive basic scheme. 相似文献
A formulation on equilibrium crystal shape determination based on the principle of virtual work is presented. The treatment is restricted to two dimensions. A corresponding discrete solution method is given. Some example cases are presented. 相似文献
A six‐month winter‐spring study was conducted in a suburb of the northern European city of Kuopio, Finland, to identify and quantify factors determining daily personal exposure and home indoor levels of fine particulate matter (PM2.5, diameter <2.5 µm) and its light absorption coefficient (PM2.5abs), a proxy for combustion‐derived black carbon. Moreover, determinants of home indoor ozone (O3) concentration were examined. Local central site outdoor, home indoor, and personal daily levels of pollutants were monitored in this suburb among 37 elderly residents. Outdoor concentrations of the pollutants were significant determinants of their levels in home indoor air and personal exposures. Natural ventilation in the detached and row houses increased personal exposure to PM2.5, but not to PM2.5abs, when compared with mechanical ventilation. Only cooking out of the recorded household activities increased indoor PM2.5. The use of a wood stove room heater or wood‐fired sauna stove was associated with elevated concentrations of personal PM2.5 and PM2.5abs, and indoor PM2.5abs. Candle burning increased daily indoor and personal PM2.5abs, and it was also a determinant of indoor ozone level. In conclusion, relatively short‐lasting wood and candle burning of a few hours increased residents’ daily exposure to potentially hazardous, combustion‐derived carbonaceous particulate matter. 相似文献
The resistance of the thermally carbonized porous silicon (TCPSi) against HF was utilized to etch a second porous layer underneath the TCPSi sensing layer. Three oxidation methods were studied to obtain electrically isolated TCPSi sensing layers for humidity sensing purposes. The present study showed that electrochemical oxidation is propitious for such applications. The other two methods, pyridine-assisted vapor and liquid oxidations, resulted in cracking at the interface of the TCPSi and oxidized PSi layers. The TCPSi sensor with an electrically isolated sensing layer was five times more sensitive than a typical TCPSi sensor. 相似文献
BACKGROUND: Screening for trisomy 21 (Down's syndrome) by measuring maternal serum alpha-fetoprotein, chorionic gonadotropin, and estriol concentrations and then performing chorionic-villus sampling or amniocentesis identifies approximately 60 percent of fetuses with this disorder. We used ultrasonography to detect increased nuchal translucency and cystic hygroma, which are characteristic features of fetuses with chromosomal defects. METHODS: We performed transvaginal ultrasonography in 10,010 unselected adolescents and women less than 40 years of age with live singleton fetuses at 10 to 15.9 weeks of gestation. Increased fetal nuchal translucency was defined as an area of translucency at least 3 mm in width, and cystic hygromas were defined as septated, fluid-filled sacs in the nuchal region. Subjects whose fetuses had these findings were offered fetal karyotyping. Information on pregnancies, deliveries, and neonates was subsequently obtained from hospital records and national birth and malformation registries. RESULTS: Nuchal translucency or cystic hygroma was seen in 76 fetuses (0.8 percent), of which 18 (24 percent) had an abnormal karyotype. The sensitivity for trisomies 21, 18, and 13 combined was 62 percent (13 of 21 fetuses), and the sensitivity for trisomy 21 alone was 54 percent (7 of 13 fetuses). CONCLUSIONS: The use of transvaginal ultrasonography to detect increased nuchal translucency and cystic hygroma is a sensitive test for fetal aneuploidy. It can be done earlier in pregnancy than serum screening, and it decreases the subsequent need for chorionic-villus sampling or amniocentesis. 相似文献