JFET/SOS devices. I. Transistor characteristics and modelingresults

A process for fabricating n-channel junction field-effect transistors (JFET) on silicon-on-sapphire (SOS) wafers has been developed. Both enhancement-mode and depletion-mode transistors were fabricated, and their characteristics were measured and are discussed. All dopants were ion implanted. A number of calculational tools, including SUPREME-II, were used to estimate the junction depths and the mode of device operation. Calculations were also performed using PISCES-II, a device-modeling program that predicts operating characteristics. The mobilities used in these calculations were reduced from bulk silicon values to account for the degraded mobility of the SOS material. The mobility of the SOS material was measured using capacitance-voltage and conductance-voltage techniques on a device with a long gate. A decrease in mobility with decreasing temperature is deduced from device behavior at low temperatures     

Hypoxia, temperature, and pH/CO2 effects on respiratory discharge from a turtle brain stem preparation

An in vitro brain stem preparation from adult turtles (Chrysemys picta) was used to examine the effects of anoxia and increased temperature and pH/CO2 on respiration-related motor output. At pH approximately 7.45, hypoglossal (XII) nerve roots produced patterns of rhythmic bursts (peaks) of discharge (O.74 +/- 0.07 peaks/min 10.0 +/- 0.6 s duration) that were quantitatively similar to literature reports of respiratory activity in conscious, vagotomized turtles. Respiratory discharge was stable for 6 h at 22 degrees C; at 32 degrees C, peak amplitude and frequency progressively and reversibly decreased with time. Two hours of hypoxia had no effect on respiratory discharge. Acutely increasing bath temperature from 22 to 32 degrees C decreased episode and peak duration and increased peak frequency. Changes in pH/CO2 increased peak frequency from zero at pH 8.00-8.10 to maxima of 0.81 +/- 0.01 and 1.44 +/- 0.02 peaks/min at 22 degrees C (pH 7.32) and 32 degrees C (pH 7.46), respectively; pH/CO2 sensitivity was similar at both temperatures. We conclude that 1) insensitivity to hypoxia indicates that rhythmic discharge does not reflect gasping behavior, 2) increased temperature alters respiratory discharge, and 3) central pH/CO2 sensitivity is unaffected by temperature in this preparation (i.e., Q10 approximately 1.0).     

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biopsies of cutaneous tumours and involved lymph nodes and clinical response to the drug has been studied. Among 50 evaluable patients, there were three complete responses (CR), four partial responses (PR), six with stable disease (SD) and 37 with progressive disease (PD), with an overall response rate of 14%. In 33 patients in whom MGMT level and clinical response could be evaluated, the tumour MGMT levels (fmol mg(-1) protein) were: CR, 158 +/- 119; PR, 607 +/- 481; NC, 171 +/- 101; PD, 185 +/- 42.3. Thus, measurements of pretreatment levels of MGMT in melanoma did not predict for response to temozolomide.     

Determination of Exposure-Response Relationships for Emissions from Building Products

Abstract Building products have been shown to affect the perceived indoor air quality in buildings. Consequently, there is a need for characterizing the emissions from building products in sensory terms to evaluate their impact on the perceived air quality. Determining the exposure-response relationship between concentration of the emission from a building product and human response is recommended. A practical method is proposed based on an air-dilution system connected to the exhaust of a ventilated small-scale test chamber. The method was used to determine the exposure-response relationships for eight building products. For each building product, samples were placed in a test chamber. A typical room was used as a reference to calculate a building-realistic area-specific ventilation rate in the test chamber. A sensory panel assessed the immediate acceptability of polluted air at four different concentrations 3, 10 and 29 days after samples of the building products were placed in the test chambers. The exposure-response relationships show that the impact of dilution of polluted air on the perceived air quality varies between building products. For some building products it may only be possible in practice to improve the perceived air quality marginally by increasing dilution. The results of the present study suggest that for such building products, source control is recommended as the remedy for poor indoor air quality, rather than an increase of the ventilation rate.     

Phase II trial of 5-fluorouracil, interferon-alpha and continuous infusion interleukin-2 for patients with metastatic renal cell carcinoma

BACKGROUND: This study was designed to evaluate the efficacy and toxicity of the combination of 5-fluorouracil, interferon-alpha, and interleukin-2 for patients with metastatic renal cell carcinoma. METHODS: Previously untreated patients with a Zubrod performance status of < or =2; adequate cardiac, pulmonary, and renal function; and absence of brain metastases were eligible. One course of therapy was 28 days. 5-fluorouracil was administered at a dose of 600 mg/m2/day as a continuous infusions on Days 1-5. Interleukin-2 also was administered as a continuous infusion on Days 1-5 at a dose of 2 million Roche U/m2/day. Interferon-alpha was given as a daily subcutaneous injection of 4 million U/m2/day. RESULTS: Fifty-five patients were enrolled in the trial and 52 were evaluable for response. All patients experienced fever and flu-like symptoms. Grade 3 or 4 nonhematologic toxic effects included hypertension (48%), dermatitis (12%), stomatitis (11%), and altered mental status (9%). There was one toxic death. Four complete responses and 12 partial responses were observed for a total response rate of 31% (95% confidence interval, 18-46%). The survival of responding patients was significantly better than that of nonresponding patients. The improvement in survival was even more significant when comparing patients with at least stable disease with those who progressed through treatment. CONCLUSIONS: The three-drug combination described in this study demonstrates activity. However, it appears to be more toxic than other regimens with similar response rates and cannot be recommended for standard practice. Changing the interleukin-2 route to subcutaneous administration may permit more continuous administration with less toxic effects.     

Rapid Process for Manufacturing Aluminum Nitride Powder

A rapid, direct nitridation process for the manufacture of sinterable aluminum nitride (A1N) powder was developed at the pilot scale. Atomized aluminum metal and nitrogen gas were heated and reacted rapidly to synthesize A1N while they passed through the reaction zone of a transport flow reactor. The heated walls of the reactor simultaneously initiated the reaction and removed the generated heat to control the exotherm. Several variations of the process were required to achieve high conversion and reduce wall deposition of the product. The fine A1N powder produced did not require a postreaction grinding step to reduce particle size. However, a secondary heat treatment, following a mild milling step to expose fresh surface, was necessary to ensure complete conversion of the aluminum. In some instances, a final air classification step to remove large particles was necessary to promote densification by pressureless sintering. The A1N powder produced was pressureless sintered with 3 wt% yttria to fabricate fully dense parts which exhibited high thermal conductivity. The powder was shown to be less sinterable than commercially available car-bothermally produced powders.