Teachers' work-related non-literature-known building-related symptoms are also connected to indoor toxicity: A cross-sectional study

A previous study showed that classical building-related symptoms (BRS) were related to indoor dust and microbial toxicity via boar sperm motility assay, a sensitive method for measuring mitochondrial toxicity. In this cross-sectional study, we analyzed whether teachers’ most common work-related non-literature-known BRS (nBRS) were also associated with dust or microbial toxicity. Teachers from 15 schools in Finland completed a questionnaire evaluating 20 nBRS including general, eye, respiratory, hearing, sleep, and mental symptoms. Boar sperm motility assay was used to measure the toxicity of extracts from wiped dust and microbial fallout samples collected from teachers’ classrooms. 231 teachers answered a questionnaire and their classroom toxicity data were recorded. A negative binomial mixed model showed that teachers’ work-related nBRS were 2.9-fold (95% CI: 1.2-7.3) higher in classrooms with highly toxic dust samples compared to classrooms with non-toxic dust samples (p = 0.024). The RR of work-related nBRS was 1.8 (95% CI: 1.1-2.9) for toxic microbial samples (p = 0.022). Teachers’ BRS appeared to be broader than reported in the literature, and the work-related nBRS were associated with toxic dusts and microbes in classrooms.     

Selective laser melting raw material commoditization: impact on comparative competitiveness of additive manufacturing

The paper analyses the impact of cheaper metal powder supplies on the comparative competitiveness of additive manufacturing (AM). By utilising two case studies, we compare the economic impact of an innovative titanium extraction method on Selective Laser Melting (SLM) and conventional methods of machining and casting. A switch-over analysis identifies the production quantities above which conventional manufacturing is more cost competitive than additive manufacturing. This analysis is performed for current raw material as well as cheaper raw material supply. The results illustrate the improved comparative competitiveness of SLM as the titanium supply is commoditised and more readily available in powder form. The responsiveness of the supply chain is improved as the switch-over point between SLM and conventional methods increases. Moreover, as the raw material supply chain for titanium is transformed through the use of this novel extraction method, the manufacturing supply chain is simplified.     

3-D Degradation analysis of railroad ballast

Degradation behaviour of aggregate particles of the size of railroad ballast (32–63 mm) is examined using Los Angeles (LA) milling and 3-D scanning techniques. Seven different rock types were tested at four stages of milling. For the analytical geometry and topography characterization, a new method based on Fourier and power spectra was used. The results are compared with those obtained using geometrical methods and traditional manual measurements. Diminishing of surface roughness and dimensions is evident. The change in roughness was 20–35% and for maximum dimensions of less than 10% in the case of hard rock types. The LA value was less than 15. For the weaker particles values of more than 40% and more than 20%, respectively, were obtained. The fractal dimension approached a value of 2 as a function of milling rates. Electronic Publication     

TAPISTRY—A Software Process Improvement Approach Tailored for Small Enterprises

TAPISTRY is a tutored process improvement approach tailored for small enterprises. The approach was developed, used and validated in an ongoing ESSI Esprit project (No 24238), called “TAPISTRY.” The TAPISTRY project adopted a downscaled assessment model of the BOOTSTRAP assessment methodology, called BootCheck, and developed a workshop-based assessment and improvement method, to form together a process improvement approach for small-to-medium-sized enterprises. In TAPISTRY workshops the participants are tutored in self-assessment and improvement planning by software process improvement experts. The resulting TAPISTRY approach was validated through the experiments performed during the TAPISTRY project. This revised version was published online in August 2006 with corrections to the Cover Date.     

Design of non-paraxial array illuminators by step-transition perturbation approach

Abstract

We introduce an efficient Fourier-domain formulation of an approximate method to model non-paraxial diffractive elements. The method is based on evaluation of local field perturbations caused by abrupt surface-profile transitions. It facilitates fast parametric optimization of binary and four-level diffractive array illuminators in the non-paraxial domain of diffractive optics. Comparison with rigorous electromagnetic theory of gratings shows that optimization with the perturbation method gives accurate results if the smallest feature size in the surface profile is larger than one wavelength. Some binary designs are demonstrated using electron beam lithography.     

Modelling of electro hydraulic free and die forming of sheet steels

Electro hydraulic forming of a range of different sheet steels was studied experimentally and with finite element methods. Four carbon and stainless sheet materials were studied. In this paper we present results on a mild steel (IF210), two high strength steels (DPX800 and TRIP700) and one stainless steel (1.4509). The flow properties of the materials were evaluated at a range of strain rates up to 1000/s. These were typical strain rates in the FE simulations. The flow properties were characterized with the Johnson Cook model. Electro hydraulic forming trails were performed with a chamber of water with a pair of electrodes on one side of the sheet. In one case free forming was performed and in the other case forming was performed into a truncated conical die. Geometrical shapes and strain distributions were evaluated after forming. A finite element model was formulated in ABAQUS explicit. The model takes the chamber filled with water into account and the effect of the electrical discharge is modeled as a pressure wave originating from the location of the electrodes. The sheet is given the properties defined by the Johnson Cook model and stiff tools are used. The forming of the sheet is described including rebound effects at the tools. The model shows satisfactory results in relation to the experimental trials regarding both shape and strains of the pressed sheets.     

A fast O(N) multiresolution polygonal approximation algorithm for GPS trajectory simplification

Recent advances in geopositioning mobile phones have made it possible for users to collect a large number of GPS trajectories by recording their location information. However, these mobile phones with built-in GPS devices usually record far more data than needed, which brings about both heavy data storage and a computationally expensive burden in the rendering process for a Web browser. To address this practical problem, we present a fast polygonal approximation algorithm in 2-D space for the GPS trajectory simplification under the so-called integral square synchronous distance error criterion in a linear time complexity. The underlying algorithm is designed and implemented using a bottom-up multiresolution method, where the input of polygonal approximation in the coarser resolution is the polygonal curve achieved in the finer resolution. For each resolution (map scale), priority-queue structure is exploited in graph construction to construct the initialized approximated curve. Once the polygonal curve is initialized, two fine-tune algorithms are employed in order to achieve the desirable quality level. Experimental results validated that the proposed algorithm is fast and achieves a better approximation result than the existing competitive methods.     

Analysis of EMG and acceleration signals for quantifying the effects of deep brain stimulation in Parkinson's disease

Deep brain stimulation (DBS) is effective in reducing motor symptoms in Parkinson's disease (PD). However, objective methods for quantifying its efficacy are lacking. We present a principal component (PC)-based tracking method for quantifying the effects of DBS in PD by using electromyography (EMG) and acceleration measurements. Ten parameters capturing PD characteristic signal features were initially extracted from isometric EMG and acceleration recordings. Using a PC approach, the original parameters were transformed into a smaller number of PCs. Finally, the effects of DBS were quantified by examining the PCs in a low-dimensional feature space. The EMG and acceleration data from 13 PD patients with DBS ON and OFF, and 13 healthy age-matched controls were used for analysis. Clinical evaluation of patients showed that their motor symptoms were effectively reduced with DBS. The analysis results showed that the signal characteristics of 12 patients were more similar to those of the healthy controls with DBS ON than with DBS OFF. These observations indicate that the PC-based tracking method can be used to objectively quantify the effects of DBS on the neuromuscular function of PD patients. Further studies are suggested to estimate the clinical sensitivity of the method to different types of PD.     

Cobalt‐Catalysed Addition of Allylidene Dipivalate to Aldehydes. A Formal Homoaldol Condensation

A Co(I)‐catalysed condensation of allylidene dipivalate with aldehydes to give (Z)‐4‐hydroxybut‐1‐enyl pivalates in 62 to 87% isolated yields, is reported. Reactions are run in acetonitrile at 0 or 25 °C depending on the nature of the aldehyde, and exploiting the Co(II)/Zn(0) redox couple for the preparation of the catalytic Co(I) species.     

Covalently Mercurated Molecular Beacon for Discriminating the Canonical Nucleobases

A highly nucleobase-discriminating metalated nucleoside analogue, 3-fluoro-2-mercuri-6-methylaniline, was incorporated into an oligonucleotide molecular beacon. Fluorescence emission spectra were measured after the addition of four different complementary strands, in which the nucleobase opposite the metalated analogue varies. The fluorescence results showed a clear binding selectivity at room temperature, in the order G>T>C>A. The selectivity is based on the different affinities between the metalated nucleoside analogue and the canonical nucleobases. The synthesized probe is capable of robust discrimination between the two purine as well as the two pyrimidine bases by fluorescence at room temperature, and more sophisticated temperature analysis allows clear separation of every canonical nucleobase. The probe would, hence, be a suitable method for the detection of single nucleotide polymorphisms.