Induction of proinflammatory cytokine and antioxidant enzyme gene expression following brief myocardial ischaemia

PURPOSE: In a recent study we found an increased resistive index immediately after extracorporeal shock wave lithotripsy (ESWL) in patients older than 60 years, which suggests renovascular disturbance. The present 26-month followup study was undertaken to investigate the relevance of elevated resistive index levels and the incidence of new onset hypertension. MATERIALS AND METHODS: Of the initial 76 patients 57, including 20 of the 23 at risk patients 60 or greater years, group 3), were followed for more than 26 +/- 6 months after ESWL. Followup included 2 resistive index measurements by Doppler ultrasound of the treated and the contralateral kidney, at least 2 blood pressure measurements 1 week apart and excretory urography as well as determination of plasma renin activity in 9 patients. RESULTS: With 1 exception, elevated resistive index levels and hypertension were observed exclusively in patients older than 60 years. In these patients the resistive index ranged between 0.65 and 0.86 (mean plus or minus standard deviation 0.74 +/- 0.05, normal less than 0.7). This increase in resistive index was statistically significant (p < 0.0001). Compared to the levels obtained immediately after ESWL, the resistive index continued to increase in all 9 patients older than 60 years who had hypertension (45%), whereas in the normotensive patients the resistive index was either stable or decreased. There was a strong positive correlation (0.903) between pathological resistive index levels and blood pressure. CONCLUSIONS: Patients older than 60 years are at risk for disturbances of renal perfusion as assessed by the resistive index, and 45% of these patients have new onset hypertension within 26 months of treatment.     

Correcting C-band radar reflectivity and differential reflectivitydata for rain attenuation: a self-consistent method withconstraints

Quantitative use of C-band radar measurements of reflectivity (Z _h) and differential reflectivity (Z_dr) demands the use of accurate attenuation-correction procedures, especially in convective rain events. With the availability of differential phase measurements (Φ_dp) with a dual-polarized radar, it is now possible to improve and stabilize attenuation-correction schemes over earlier schemes which did not use Φ_dp. The recent introduction of constraint-based correction schemes using Φ_dp constitute an important advance. In this paper, a self-consistent, constraint-based algorithm is proposed and evaluated which extends the previous approaches in several important respects. Radar data collected by the C-POL radar during the South China Sea Monsoon Experiment (SCSMEX) are used to illustrate the correction scheme. The corrected radar data are then compared against disdrometer-based scattering simulations, the disdrometer data being acquired during SCSMEX. A new algorithm is used to retrieve the median volume diameter from the corrected Z_h, corrected Z_dr , and K_dp radar measurements which is relatively immune to the precise drop axis ratio versus drop diameter relation. Histograms of the radar-retrieved D₀ compared against D₀ from disdrometer data are in remarkable good agreement lending further validity to the proposed attenuation-correction scheme, as well as to confidence in the use of C-band radar for the remote measurement of rain microphysics     

Potential effects of umami ingredients on human health: Pros and cons

Abstract

Umami taste is the most recent confirmed basic taste in addition to sour, sweet, bitter, and salty. It has been controversial because of its effects on human nutritional benefit. Based on the available literatures, this review categorized 13 positive and negative effects of umami taste on human health. On the positive side, umami taste can improve food flavor and consumption, improve nutrition intake of the elderly and patients, protect against duodenal cancer, reduce ingestion of sodium chloride, decrease consumption of fat, and improve oral functions. On the other hand, umami taste can also induce hepatotoxicity, cause asthma, induce migraine headaches, damage the nervous system, and promote obesity. Due to its novelty, there are many functions and effects of umami taste waiting to be discovered. With further investigation, more information regarding the effects of umami taste on human health will be discerned.     

Palladium‐nanoparticle intercalated vermiculite for selective hydrogenation of α,β‐unsaturated aldehydes

Palladium nanoparticles were generated in the interlamellar region of swelling 2:1 type vermiculite clay using an adsorption excess isotherm. An adsorption excess isotherm was constructed for vermiculite after exchanging the exchangeable Na⁺ ions in the interlamellar region using a binary liquid mixture (ethanol:toluene). Based on adsorption excess isotherm, 1% w/w palladium was intercalated into the interlamellar space of vermiculite. The Pd‐intercalated vermiculite was characterized by X‐ray diffraction, transmission electron microscopy and atomic absorption spectroscopy. The 1% w/w Pd‐intercalated vermiculite was tested for its catalytic activity towards selective hydrogenation reactions involving some α,β‐unsaturated carbonyl compounds using a pulse reactor and its catalytic activity was compared with commercial 1% Pd/C. The intercalated catalyst was found to be very selective towards the desired product of unsaturated alcohols. Copyright © 2007 Society of Chemical Industry     

Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy

The purpose of this study was to examine how antigen retrieval affected the yield of immunogold labeling on epoxy sections based on embedding with different amounts of accelerator. The concentration of accelerator DMP-30 (tri(dimethyl amino methyl) phenol) was varied in the range of 0-8% in the processing of the tissue for epoxy embedding. Immunogold labeling was performed on epoxy sections and LR-White sections of fibrin clots and renal tissue with IgG-deposits, and the antibodies used were anti-fibrinogen anti-IgG and, respectively. For some of the sections antigen retrieval was performed by heating the sections in citrate buffer. In all cases, the yield of immunogold labeling increased following antigen retrieval. The increase (%) in the yield of immunogold labeling as a result of antigen retrieval was larger for epoxy sections than for LR-White sections. The immunolabeling on high-accelerator epoxy sections exposed to antigen retrieval was about 20% more intense than on untreated LR-White sections both for IgG and fibrinogen. In addition to breaking fixations bonds introduced by the chemical fixation, we believe that the antigen retrieval also breaks bonds between the epoxy resin and the embedded tissue. The combination of increased amount of accelerator during tissue processing for epoxy embedding and antigen retrieval by heating in citrate buffer is a potent method for increasing specific immunolabeling on epoxy sections.     

Internal pressure test for characterizing fast-fracture reliability of grinding wheels

A constant danger associated with the use of most grinding wheels (vitrified-bond alumina and silicon carbide wheels) is the possibility of fracture during operation. A standard practice is to subject newly manufactured wheels to a spin test and accept wheels that survive. We propose an internal pressure test which offers a simpler, more economical alternative to the spin test for testing grinding wheels. Probabilities of failure in the internal pressure test are correlated with failure probabilities in the spin test using probabilistic fracture mechanics. Results indicate a reasonably good correlation between the two tests, thus demonstrating their equivalence. A scheme for the easy implementation of the internal pressure test to detect damage in grinding wheels is outlined.     

Hydrometeor classification system using dual-polarization radar measurements: model improvements and in situ verification

A hydrometeor classification system based on a fuzzy logic technique using dual-polarization radar measurements of precipitation is presented. In this study, five dual-polarization radar measurements (namely horizontal reflectivity, differential reflectivity, specific differential phase, correlation coefficient, and linear depolarization ratio) and altitude relating to environmental melting layer are used as input variables of the system. The hydrometeor classification system chooses one of nine different hydrometeor categories as output. The system presented in this paper is a further development of an existing hydrometeor classification system model developed at Colorado State University (CSU). The hydrometeor classification system is evaluated by comparing inferred results from the CSU CHILL Facility dual-polarization radar measurements with the in situ sample data collected by the T-28 aircraft during the Severe Thunderstorm Electrification and Precipitation Study.