Phenomena-based thermal-hydraulic modeling requirements for systems analysis of a Modular High Temperature Gas-Cooled Reactor

The Modular High Temperature Gas-Cooled Reactor (MHTGR) is a candidate design for new production and commercial power nuclear reactors. The MHTGR has inherent safety features including: (1) passive shutdown and decay heat removal, (2) reduced requirements for operator intervention, thereby reducing sensitivity to operator error, and (3) long time intervals for corrective action. In support of the Department of Energy's (DOE) initial development of the design, the authors have completed an evaluation of the thermal-hydraulic phenomena that will dominate the plant response during representative normal, off-normal and accident conditions. Phenomena having significance to the plant behavior have been identified, and ranked with respect to their relative importance in satisfying operational, investment and/or safety criteria. The resulting information provides the basis for evaluating the applicability of existing computer codes, and defines the requirements for the development of new codes, for thermal-hydraulic systems analysis. The phenomena-based requirements also support the quality assurance related verification and validation of these codes. This paper briefly describes the methodology employed, and gives illustrative examples of the resulting requirements. References are cited for reports that document the full body of requirements and provide additional information for the methodology.     

多内核、多线程的SoC引致调试困难

有经验的开发人员都知道,要保证嵌入式产品的成功实现、调试和维护,好的工具支持是非常关键的.SoC(系统芯片)设计带来了一系列新的问题,使好的工具支持变得更加关键.部分问题可以归因于SoC设计使用的部件,其可访问性和可视性本来就有所下降;其它原因则可归因于在硬件和软件方面复杂性的增加.     

Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure. A preliminary investigation

STUDY OBJECTIVE: To determine whether alterations of platelet reactivity occur during obstructive sleep apnea (OSA) and, if so, whether therapy with nasal-continuous positive airway pressure (N-CPAP) alters this reactivity. DESIGN: Patients with suspected moderate to severe OSA had blood drawn for spontaneous platelet aggregation (sAGG) and activation (sACT) measurements at hourly intervals during diagnostic polysomnography (PSG) and, in those with confirmed OSA, on a separate night during which N-CPAP was applied. SETTING: Tertiary care center sleep laboratory. PATIENTS: Six patients with OSA had matched blood samples drawn on both diagnostic and N-CPAP treatment nights. Five patients without confirmed OSA served as controls. INTERVENTIONS: N-CPAP was applied to those patients with OSA and pressures adjusted with goals of eliminating apneas; N-CPAP was then maintained through the night. MEASUREMENTS AND RESULTS: sACT and sAGG were measured using flow cytometric determination of P-selectin expression using a monoclonal antibody. Platelet aggregation was assessed by measuring the proportion of platelets larger than resting platelets by light scatter techniques. Mean values for sACT and sAGG were higher on the diagnostic night compared with treatment night (p = 0.001 and p = 0.003, analysis of variance, respectively). The mean baseline supine sACT compared with completion supine sACT for both diagnostic and N-CPAP nights also revealed significant differences (mean = 16.6 +/- 3.5% vs 36.9 +/- 7.5%, p = 0.04; and 11.9 +/- 3% vs 39.5 +/- 9.1%, p = 0.04). Platelet activation during sleep in five subjects without OSA resembles that found in patients with OSA during N-CPAP. CONCLUSIONS: Increased platelet sACT and sAGG occur during sleep in patients with OSA. This effect is greatly reduced by N-CPAP.     

Review of Can Love Last? The Fate of Romance Over Time.

Review of book: Stephen Mitchell. Can Love Last? The Fate of Romance Over Time. New York: Norton, 2002, 223 pp. Reviewed by Timothy J. Zeddies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

When laws and ethics collide: What should psychologists do?

At times the laws under which psychologists function may appear to contradict generally recognized ethical values and/or good clinical care. When these circumstances arise, psychologists must determine if a conflict really exists and, if so, seek solutions that reconcile respect for the law with their ethical values. At times, psychologists may decide to follow the law despite their ethical concerns. At other times, they may determine that a conscientious objection is warranted. The authors recommend options to consider when these situations arise and offer a decision-making process. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Congenital adrenal hyperplasia presenting as massive adrenal incidentalomas in the sixth decade of life: report of two patients with 21-hydroxylase deficiency

Divergent recommendations exist regarding the evaluation of adrenal incidentalomas. Recent data have indicated a prevalence of adrenal tumors of 71% in nonclassical congenital adrenal hyperplasia (CAH) and unmasked heterozygotes. These data expand the differential diagnosis of such incidental tumors and substantially modify the approach to their evaluation. We present two patients, female pseudohermaphrodites with the simple virilizing form of CAH and 21-hydroxylase deficiency, who functioned successfully as married phenotypic males. Both came to medical attention in the sixth decade by virtue of massive adrenal incidentalomas encountered in the evaluation of recurrent urinary tract infections. Each had a 46, XX karyotype, no palpable testes, and markedly elevated baseline levels of 17-hydroxyprogesterone (17-OH Prog) of 6086 ng/dL and 6750 ng/dL. Both responded appropriately to dexamethasone suppression with reduction of 17-OH Prog, androgens and, in the second patient, ACTH to normal or near normal levels. Histologic and autopsy examination of the first patient's tumor and computed tomographic characteristics of the second revealed a benign adenoma and myelolipoma respectively. We extend and confirm previous recommendations that CAH be included in the differential diagnosis of adrenal incidentaloma and that baseline 17-OH Prog. levels be obtained, with ACTH stimulation if necessary, to diagnose the presence of nonclassical CAH.     

Pseudoexstrophy

Pseudoexstrophy is a rare, mild exstrophy variant which involves the major musculoskeletal defects of the exstrophy complex without any associated defect in the urinary system. A case is reported presenting at birth as an umbilical positional anomaly. Differential diagnosis and management are reviewed.