Active stereo: integrating disparity, vergence, focus, aperture andcalibration for surface estimation

An approach to integrating stereo disparity, camera vergence, and lens focus to exploit their complementary strengths and weaknesses through active control of camera focus and orientations is presented. In addition, the aperture and zoom settings of the cameras are controlled. The result is an active vision system that dynamically and cooperatively interleaves image acquisition with surface estimation. A dense composite map of a single contiguous surface is synthesized by automatically scanning the surface and combining estimates of adjacent, local surface patches. This problem is formulated as one of minimizing a pair of objective functions. The first such function is concerned with the selection of a target for fixation. The second objective function guides the surface estimation process in the vicinity of the fixation point. Calibration parameters of the cameras are treated as variables during optimization, thus making camera calibration an integral, flexible component of surface estimation. An implementation of this method is described, and a performance evaluation of the system is presented. An average absolute error of less than 0.15% in estimated depth was achieved for a large surface having a depth of approximately 2 m     

The separation of SEC curves of HDPE into flory distributions

A technique is reported here whereby molecular weight distribution curves from size exclusion chromatography (SEC) obtained on high-density polyethylene (HDPE) can be deconvolved into a series of Flory-distribution curves using a commercially available computer software system. Our analysis has shown that five to seven individual Flory distributions describe HDPE with better than a 99.9% degree of fit. We impute from this that upon taking proper precautions, we can consider these HDPE resins to be derived from at least this number of distinct catalyst sites and, furthermore, that modification of the sites will lead to a modification of the resultant resin. © 1993 John Wiley & Sons, Inc.     

A microcomputer control system for the measurement of fatigue crack growth data

A microcomputer-based system for the measurement of fatigue crack growth da/dn versus cyclic stress intensity factor ΔK data using compact-tension test specimens is described. The procedure has been developed to allow automatic measurement of crack growth rate under any specified combination and sequence of load conditions, i.e. ΔK and R (stress ratio) and includes the capability of establishing the threshold cyclic stress intensity factor ΔK₀. Crack extension measurement is effected from the elastic compliance evaluated from the AC component of the load and displacement signals to an accuracy of -3 μm every 1000 load cycles. Results from a typical low-alloy-steel rotor forging are presented to illustrate the use of the system.     

The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450

Dietary indole-3-carbinol inhibits carcinogenesis in rodents and trout. Several mechanisms of inhibition may exist. We reported previously that 3,3'-diindolylmethane, an in vivo derivative of indole-3-carbinol, is a potent noncompetitive inhibitor of trout cytochrome P450 (CYP) 1A-dependent ethoxyresorufin O-deethylase with Ki values in the low micromolar range. We now report a similar potent inhibition by 3,3'-diindolylmethane of rat and human CYP1A1, human CYP1A2, and rat CYP2B1 using various CYP-specific or preferential activity assays. 3,3'-Diindolylmethane also inhibited in vitro CYP-mediated metabolism of the ubiquitous food contaminant and potent hepatocarcinogen, aflatoxin B1. There was no inhibition of cytochrome c reductase. In addition, we found 3,3'-diindolylmethane to be a substrate for rat hepatic microsomal monooxygenase(s) and tentatively identified a monohydroxylated metabolite. These observations indicate that 3,3'-diindolylmethane can inhibit the catalytic activities of a range of CYP isoforms from lower and higher vertebrates in vitro. This broadly based inhibition of CYP-mediated activation of procarcinogens may be an indole-3-carbinol anticarcinogenic mechanism applicable to all species, including humans.     

Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: unyoked eye movements in a mammal

OBJECTIVE: Osteoarthritis (OA) is characterized by progressive loss of articular cartilage in the involved joint. Accurate, reproducible measurement of the thickness of the cartilage in vivo, however, is difficult. Because development of an ultrasonic imaging device for intraarticular use is feasible and would permit acquisition of information that could complement the assessment of articular cartilage made at arthroscopy, we evaluated the efficacy of high frequency ultrasound in assessing the thickness and subsurface characteristics of normal and OA cartilage. METHODS: Blocks of human femoral cartilage and subchondral bone and chips of cartilage alone were examined in vitro with an experimental 25 MHz pulse-echo ultrasound scanner that portrayed cross sections of the cartilage as B-mode images. The gross and histologic appearance of the articular surface was used to identify specimens of unblemished, normal cartilage and OA cartilage. The speed of sound in cartilage, determined from measurements of cartilage thickness and sound transmission, was related to its biochemical composition. RESULTS: The speed of sound in normal cartilage (1658 +/- 185 m/s, n = 27) was greater than that in OA cartilage (1581 +/- 148 m/s, n = 40, p = 0.06), but was not related to the cartilage water content or the concentration of uronic acid or hydroxyproline. Images of normal cartilage showed a smooth echo band at the tissue surface with a hypoechoic matrix; in scans of fibrillated cartilage the width of this band was proportional to the depth of fibrillation (r = 0.78). Ultrasonic and histologic measurements of OA cartilage thickness were closely correlated (r = 0.87) and the mean coefficient of variation for repeated measurements was 2%. CONCLUSION: High frequency ultrasonic images obtained in vitro provide highly accurate and reproducible measurements of the thickness and subsurface characteristics of normal and OA articular cartilage.