全文获取类型
收费全文 | 2689篇 |
免费 | 118篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 23篇 |
化学工业 | 345篇 |
金属工艺 | 26篇 |
机械仪表 | 28篇 |
建筑科学 | 58篇 |
矿业工程 | 2篇 |
能源动力 | 62篇 |
轻工业 | 334篇 |
水利工程 | 13篇 |
石油天然气 | 9篇 |
无线电 | 130篇 |
一般工业技术 | 248篇 |
冶金工业 | 1265篇 |
原子能技术 | 16篇 |
自动化技术 | 251篇 |
出版年
2024年 | 3篇 |
2023年 | 7篇 |
2022年 | 10篇 |
2021年 | 40篇 |
2020年 | 24篇 |
2019年 | 45篇 |
2018年 | 44篇 |
2017年 | 56篇 |
2016年 | 56篇 |
2015年 | 45篇 |
2014年 | 69篇 |
2013年 | 121篇 |
2012年 | 101篇 |
2011年 | 94篇 |
2010年 | 89篇 |
2009年 | 95篇 |
2008年 | 74篇 |
2007年 | 85篇 |
2006年 | 53篇 |
2005年 | 62篇 |
2004年 | 58篇 |
2003年 | 50篇 |
2002年 | 38篇 |
2001年 | 37篇 |
2000年 | 36篇 |
1999年 | 50篇 |
1998年 | 406篇 |
1997年 | 203篇 |
1996年 | 178篇 |
1995年 | 104篇 |
1994年 | 82篇 |
1993年 | 81篇 |
1992年 | 12篇 |
1991年 | 30篇 |
1990年 | 18篇 |
1989年 | 29篇 |
1988年 | 20篇 |
1987年 | 18篇 |
1986年 | 18篇 |
1985年 | 21篇 |
1984年 | 4篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 11篇 |
1979年 | 7篇 |
1978年 | 7篇 |
1977年 | 29篇 |
1976年 | 66篇 |
1975年 | 2篇 |
1958年 | 1篇 |
排序方式: 共有2810条查询结果,搜索用时 31 毫秒
41.
The antifibrotic effect of the mismatched double-stranded RNA, Ampligen (poly(I).poly(C12U)), was evaluated in a bleomycin-mouse model of pulmonary fibrosis. Mice received a single intratracheal dose of bleomycin (0.125 U/mouse) or saline (50 microL) at the beginning of the experiment, followed by 5 or 6 intraperitoneal injections of Ampligen (1.0, 5.0, 10.0, 15.0, or 25.0 mg/kg) or saline at regular intervals for 2 weeks. Ampligen did not produce increased mortality or weight loss by itself. However, it produced varying degrees of mortality in combination with bleomycin. Five injections of 10 mg/kg Ampligen or three injections of 25 mg/kg Ampligen plus three injections of 10 mg/kg Ampligen in combination with bleomycin .produced significant reductions in lung collagen accumulation as indicated by lung hydroxyproline content compared to the bleomycin control group. Animals receiving bleomycin plus Ampligen at all dosages had significantly reduced prolyl hydroxylase activity compared to the bleomycin control group. Lipid peroxidation and bronchoalveolar lavage fluid (BALF)-supernatant protein content for the groups receiving bleomycin plus Ampligen were not reduced compared to the bleomycin control group. In the BALF-supernatant, the activity of acid phosphatase, a lysosomal enzyme produced by neutrophils, monocytes, and macrophages, was significantly decreased in the group receiving bleomycin plus 10 mg/kg Ampligen. Also, selected BALF differential immune cell counts were reduced in some of the groups receiving bleomycin plus Ampligen, but not in a consistent or dose-dependent manner. The results of this study indicate that Ampligen can significantly reduce the bleomycin-induced increased collagen accumulation and may be therapeutically useful in the management of lung fibrosis in humans. 相似文献
42.
BV Murthy AS Muerhoff SM Desai SN Natov BA Bouthot R Ruthazer CH Schmid AS Levey IK Mushahwar BJ Pereira 《Canadian Metallurgical Quarterly》1998,53(6):1769-1774
The etiology of liver disease remains unknown in about 4 to 23% of dialysis patients and 10 to 16% of renal transplant recipients. A search for other causative agents of liver disease led to the discovery of the GB group of viruses. We studied the association between the presence of GB virus C (GBV-C) infection, known risk factors for parenterally-transmitted infections and history or laboratory evidence of liver disease among end-stage renal disease (ESRD) patients referred for renal transplantation to the New England Organ Bank, MA. Stored sera from patients on the renal transplantation waiting list between November 1986 and June 1990 were tested for antibody to hepatitis C virus (HCV). Sera were available in 1544 of 3243 (48%) patients, and anti-HCV was detected by ELISA3 in 287 (19%). All 287 anti-HCV positive patients formed the anti-HCV positive cohort and 286 randomly selected anti-HCV negative patients formed the anti-HCV negative cohort (573 patients overall). Additional sera were available for GBV-C RNA testing in 465 of 573 (81%) patients, and GBV-C RNA was detected by RT-PCR in 146. The overall extrapolated prevalence of serum GBV-C RNA was 29%. The prevalence of serum GBV-C RNa among anti-HCV positive patients (35%) was not significantly different from that among anti-HCV negative patients (29%; P = 0.22). In a univariate analysis, compared to patients without GBV-C RNA, patients with serum GBV-C RNA were younger [odds ratio (OR) 0.98 per year of age, P = 0.01], had a lower proportion of males (OR 0.64, P = 0.03), lower proportion of patients with diabetes mellitus (OR 0.44, P = 0.01), higher proportion of patients with a previous transplantation (OR 1.53, P = 0.04), longer duration of dialysis at the time of enrollment (OR 1.004 per month on dialysis, P = 0.03), and a higher proportion of patients with history of transfusions (OR 4.58, P = 0.01). Serum GBV-C RNA was not associated with a significantly increased OR for history of liver disease or non-A, non-B hepatitis, or elevated serum alanine aminotransferase levels. In a step-wise multivariate regression analysis, a younger age (OR 0.98 per year of age, P = 0.03), and history of blood transfusions (OR 3.89, P = 0.03) were associated with an increased OR for serum GBV-C RNA, while diabetes mellitus was associated with a decreased OR for GBV-C RNA (OR 0.47, P = 0.01). Anti-HCV was not a predictor of serum GBV-C RNA (OR 1.07, P = 0.77). The results of this study support the fact that GBV-C is a parenterally transmitted virus and shed light on the modes of transmission of GBV-C among ESRD patients. However, the association with liver disease remains to be established. 相似文献
43.
SN Dedysh NS Panikov W Liesack R Grosskopf J Zhou JM Tiedje 《Canadian Metallurgical Quarterly》1998,282(5387):281-284
Acidic northern wetlands are an important source of methane, one of the gases that contributes to global warming. Methane oxidation in the surface of these acidic wetlands can reduce the methane flux to the atmosphere up to 90 percent. Here the isolation of three methanotrophic microorganisms from three boreal forest sites is reported. They are moderately acidophilic organisms and have a soluble methane monooxygenase. In contrast to the known groups of methanotrophs, 16S ribosomal DNA sequence analysis shows that they are affiliated with the acidophilic heterotrophic bacterium Beijerinckia indica subsp. indica. 相似文献
44.
Kazadi N. Mutoji Mingxia Sun Garrett Elliott Isabel Y. Moreno Clare Hughes Tarsis F. Gesteira Vivien J. Coulson-Thomas 《International journal of molecular sciences》2021,22(11)
Corneal transparency relies on the precise arrangement and orientation of collagen fibrils, made of mostly Type I and V collagen fibrils and proteoglycans (PGs). PGs are essential for correct collagen fibrillogenesis and maintaining corneal homeostasis. We investigated the spatial and temporal distribution of glycosaminoglycans (GAGs) and PGs after a chemical injury. The chemical composition of chondroitin sulfate (CS)/dermatan sulfate (DS) and heparan sulfate (HS) were characterized in mouse corneas 5 and 14 days after alkali burn (AB), and compared to uninjured corneas. The expression profile and corneal distribution of CS/DSPGs and keratan sulfate (KS) PGs were also analyzed. We found a significant overall increase in CS after AB, with an increase in sulfated forms of CS and a decrease in lesser sulfated forms of CS. Expression of the CSPGs biglycan and versican was increased after AB, while decorin expression was decreased. We also found an increase in KS expression 14 days after AB, with an increase in lumican and mimecan expression, and a decrease in keratocan expression. No significant changes in HS composition were noted after AB. Taken together, our study reveals significant changes in the composition of the extracellular matrix following a corneal chemical injury. 相似文献
45.
The interaction of the dinucleotides d(ApG) and d(ApA) with [Pd(aa)Cl(2)], where aa = L- or D-histidine or the methyl ester of L-histidine, and with [Pt(Met)Cl(2)], where Met = L-methionine was studied by (1)H and (13)C NMR and CD measurements. In the case of the L-histidine and L-histidineOMe, the reaction with d(ApG) appeared to give the bifunctional adducts Pd(L-Histidine)N1(1)N7(2) and Pd(L-HisOMe)N1(1)N7(2), but the behavior with D-histidine suggested the formation of the monofunctional adduct Pd(D-His)N7(2). The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His). The Pt(II)-L-methionine complex in both reactions with d(ApG) and d(ApA) seemed to yield mainly adducts Pt(L-Met)N7(1)N7(2) but the existence of adducts Pt(L-Met)N1(1)N7(2) cannot be ruled out. 相似文献
46.
The biosynthesis of fatty acids in the diatomPhaeodactylum tricornutum was studied. The diatom was incubated with sodium [114C] acetate and the acids [1-14C] palmitic, [1-14C] stearic, [1-14C] linoleic and [1-14C] α-linolenic. The distribution of radioactivity in the products was determined by gas liquid radiochromatography. The diatom
synthesized “de novo” not only saturated and monounsaturated fatty acids, but also linoleic, α-linolenic and other fatty acids
including the highly polyunsaturated 20∶5ω3 and 22∶6ω3. When labeled acetate, stearic, α-linolenic or even linoleic acid were
incubated with the diatom, the polyunsaturated C20 fatty acids synthesized belonged predominantly to the ω 3 family. The existence of Δ9, Δ6, Δ5, Δ4, ω6 and possibly ω3 desaturases
inP. tricornutum is suggested.
Member of the Carrera del Investigador Científico of the Comisión de Investigaciones Científicas de la Provincia de Buenos
Aires.
Member of the Carrera del Investigador Cientifico of the Consejo Nacional de Investigaciones Cientificas y Técnicas. 相似文献
47.
Summary In this work we present an experimental study of flow-induced degradation of hydrolyzed polyacrylamide in aqueous solutions flowing through porous media. The degradation is analyzed by passing the solution repeatedly through the medium at a constant flow velocity and the degraded solution is then characterized by porous media and opposed jets flows. When the polyacrylamide is dissolved in deionized water, it exhibits a gradual extension thickening in the flow through porous media and opposed jets. In this case, the polymer degrades as it passes through the porous medium even at relatively low flow rates. When the polyacrylamide is dissolved in an NaCl solution, it exhibits critical extension thickening in porous media flows, and it only degrades at Reynolds numbers that are higher than the onset of the extension thickening behavior. Chain degradation is therefore only encountered when extension thickening is produced. The results also show that the extent of degradation decreases as the pore size decreases. 相似文献
48.
David F. Barrero Julio César Hernández‐Castro Pedro Peris‐Lopez David Camacho María D. R‐Moreno 《Expert Systems》2014,31(1):9-19
Radio frequency identification (RFID) is a powerful technology that enables wireless information storage and control in an economical way. These properties have generated a wide range of applications in different areas. Due to economic and technological constrains, RFID devices are seriously limited, having small or even tiny computational capabilities. This issue is particularly challenging from the security point of view. Security protocols in RFID environments have to deal with strong computational limitations, and classical protocols cannot be used in this context. There have been several attempts to overcome these limitations in the form of new lightweight security protocols designed to be used in very constrained (sometimes called ultra‐lightweight) RFID environments. One of these proposals is the David–Prasad ultra‐lightweight authentication protocol. This protocol was successfully attacked using a cryptanalysis technique named Tango attack. The capacity of the attack depends on a set of boolean approximations. In this paper, we present an enhanced version of the Tango attack, named Genetic Tango attack, that uses Genetic Programming to design those approximations, easing the generation of automatic cryptanalysis and improving its power compared to a manually designed attack. Experimental results are given to illustrate the effectiveness of this new attack. 相似文献
49.
The effects of different inorganic and organic counterions on the physicochemical behavior of three commercial linear alkylbenzene
sulfonates (LAS) have been studied. It has been found that the counterion hydration radius of the corresponding commercial
linear alkylbenzene sulfonates has great influence on solubility, viscosity, surface tension and critical micelle concentration
(CMC). The counterion has no influence on the detergency performance of the finished formulation. The alkyl chain length and
the presence of tetralines have an important influence on solubility, viscosity and surface tension. 相似文献
50.
We present an interactive approach for decompositing bitmap drawings and studio photographs into opaque and semi‐transparent vector layers. Semi‐transparent layers are especially challenging to extract, since they require the inversion of the non‐linear compositing equation. We make this problem tractable by exploiting the parametric nature of vector gradients, jointly separating and vectorising semi‐transparent regions. Specifically, we constrain the foreground colours to vary according to linear or radial parametric gradients, restricting the number of unknowns and allowing our system to efficiently solve for an editable semi‐transparent foreground. We propose a progressive workflow, where the user successively selects a semi‐transparent or opaque region in the bitmap, which our algorithm separates as a foreground vector gradient and a background bitmap layer. The user can choose to decompose the background further or vectorise it as an opaque layer. The resulting layered vector representation allows a variety of edits, such as modifying the shape of highlights, adding texture to an object or changing its diffuse colour. 相似文献