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141.
DL Prout C Zafiratos TN Taddeucci J Ullmann RC Byrd TA Carey P Lisowski JB McClelland LJ Rybarcyk W Sailor W Amian M Braunstein D Lind DJ Mercer D Cooper S DeLucia B Luther DG Marchlenski E Sugarbaker J Rapaport BK Park E Gülmez CA Whitten CD Goodman W Huang D Ciskowski WP Alford 《Canadian Metallurgical Quarterly》1995,52(1):228-242
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AA Schinzel L Brecevic F Bernasconi F Binkert F Berthet A Wuilloud WP Robinson 《Canadian Metallurgical Quarterly》1994,31(10):798-803
A 7 year old girl with intrachromosomal triplication 46,XX,-15,+der(15)(pter-->q13::q13-->q11::q11-->qter) resulting in tetrasomy of 15q11-q13 is reported. Fluorescence in situ hybridisation confirmed that the tetrasomic region included the entire segment normally deleted in Prader-Willi and Angelman syndrome patients, and breakpoints were similar to those reported in two tandem duplications of 15q11-q13. The middle repeat was inverted, suggesting a possible origin through an inverted duplication intermediate. Microsatellite analysis showed that the rearrangement was of maternal origin and involved both maternal homologues. Clinical findings included multiple minor anomalies (a fistula over the glabella, epicanthic folds, downward slanting palpebral fissures, ptosis of the upper lids, strabismus, a broad and bulbous tip of the nose, and small hands and feet), motor and mental retardation, a seizure disorder, and limited verbal abilities. In addition, immunological examination disclosed a selective immunodeficiency. The overall phenotype did not clearly resemble that of cases with tetrasomy 15pter-q13 associated with an extra inv dup(15)(pter-->q13:q13-->pter) chromosome. The latter aberration causes more severe mental deficit and intractable seizures, but less marked phenotypic alterations, although some overlap in mild facial dysmorphic features is present. A number of features common to Angelman syndrome were also observed in the patient. 相似文献
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The therapeutic effectiveness of surgery, chemotherapy, and immunotherapy alone and in combination were studied in the B16 melanoma model. The sequence of chemotherapy and immunotherapy as adjuvants to surgery proved important: Chemotherapy was significantly better when given before surgery; immunotherapy was more effective when delivered after surgery. The most effective therapeutic regimen was a combination of all three modalities: a single course of chemotherapy preceding surgery followed by immunotherapy. 相似文献
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The occurrence of first cousin couples was 2.90/00 in Hungary involving three different population samples (about 2,000, 1,000 and 2,000 women after delivery in the capital, two cities, and a city with agricultural characteristics, respectively). 相似文献
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