Proper Learning Algorithm for Functions of k Terms under Smooth Distributions

In this paper, we introduce a probabilistic distribution, called a smooth distribution, which is a generalization of variants of the uniform distribution such as q-bounded distribution and product distribution. Then, we give an algorithm that, under the smooth distribution, properly learns the class of functions of k terms given as _k ^k_n={g(f₁(v), …, f_k(v)) | g _k, f₁, …, f_{k n}} in polynomial time for constant k, where _k is the class of all Boolean functions of k variables and _n is the class of terms over n variables. Although class _k ^k_n was shown by Blum and Singh to be learned using DNF as the hypothesis class, it has remained open whether it is properly learnable under a distribution-free setting.     

High Atom Efficiency in Sc(OTf)3‐Catalyzed Allylation of Aldehydes with Tetraallyltin

The high atom efficiency was achieved through addition of Ac₂O in the Sc(OTf)₃‐catalyzed allylation of aldehyde with tetraallytin in a 4 : 1 molar ratio.     

A method of single-phase PWM for an independent power supply in photovoltaic power generation systems

We propose a method of single-phase PWM for an independent power supply in photovoltaic power generation systems. This new PWM is derived by comparing levels of signal waves with one of carrier waves which have bipolar swing different from unipolar swing in the conventional PWM. In this PWM, we can use a battery with lower voltage in combination with the photovoltaic power generation; fundamental level of output voltage is raised by about 11%, though poor in quality of waveforms. © 1998 Scripta Technica. Electr Eng Jpn, 122(4): 55–62, 1998     

Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes

Interleukin (IL) 23 (p19/p40) plays a critical role in the pathogenesis of psoriasis and is upregulated in psoriasis skin lesions. In clinical practice, anti-IL-23Ap19 antibodies are highly effective against psoriasis. IL-39 (p19/ Epstein-Barr virus-induced (EBI) 3), a newly discovered cytokine in 2015, shares the p19 subunit with IL-23. Anti-IL-23Ap19 antibodies may bind to IL-39; also, the cytokine may contribute to the pathogenesis of psoriasis. To investigate IL23Ap19- and/or EBI3-including cytokines in psoriatic keratinocytes, we analyzed IL-23Ap19 and EBI3 expressions in psoriasis skin lesions, using immunohistochemistry and normal human epidermal keratinocytes (NHEKs) stimulated with inflammatory cytokines, using quantitative real-time polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and liquid chromatography-electrospray tandem mass spectrometry (LC-Ms/Ms). Immunohistochemical analysis showed that IL-23Ap19 and EBI3 expressions were upregulated in the psoriasis skin lesions. In vitro, these expressions were synergistically induced by the triple combination of tumor necrosis factor (TNF)-α, IL-17A, and interferon (IFN)-γ, and suppressed by dexamethasone, vitamin D3, and acitretin. In ELISA and LC-Ms/Ms analyses, keratinocyte-derived IL-23Ap19 and EBI3, but not heterodimeric forms, were detected with humanized anti-IL-23Ap19 monoclonal antibodies, tildrakizumab, and anti-EBI3 antibodies, respectively. Psoriatic keratinocytes may express IL-23Ap19 and EBI3 proteins in a monomer or homopolymer, such as homodimer or homotrimer.     

Quantitative risk assessment of noroviruses in drinking water based on qualitative data in Japan

Noroviruses are one of the major causes of viral gastroenteritis in Japan. A quantitative risk assessment was conducted to evaluate the health risk caused by this virus in drinking water. A Monte Carlo analysis was used to calculate both the probability of infection and the disease burden using disability-adjusted life years (DALYs). The concentration of noroviruses in tap water was estimated based on qualitative data and a most probable number (MPN) method with an assumed Poisson lognormal distribution. This numerical method was evaluated using two sets of available count data of Cryptosporidium: that collected from a river and that found in tap water in Japan. The dose-response relationships for noroviruses were estimated using assumed ID50 (10 or 100). The annual risk was higher than the US-EPA acceptable level (10(-4) [infection/ person-year]) but around the WHO level (10(-6) [DALYs/ person-year]). As suggested by others, since microbial concentrations are generally lognormally distributed, the arithmetic mean was directly related to the annual risk, suggesting that the arithmetic mean is more useful in representing the degree of microbial contamination than the geometric mean.     

Mechanically durable and highly conductive elastomeric composites from long single-walled carbon nanotubes mimicking the chain structure of polymers

By using long single-walled carbon nanotubes (SWNTs) as a filler possessing the highest aspect ratio and small diameter, we mimicked the chain structure of polymers in the matrix and realized a highly conductive elastomeric composite (30 S/cm) with an excellent mechanical durability (4500 strain cycles until failure), far superior to any other reported conductive elastomers. This exceptional mechanical durability was explained by the ability of long and traversing SWNTs to deform in concert with the elastomer with minimum stress concentration at their interfaces. The conductivity was sufficient to operate many active electronics components, and thus this material would be useful for practical stretchable electronic devices.     

Boiling heat transfer from a horizontal flat plate in a pool of liquid hydrogen

Heat transfer from a flat plate facing upward immersed in a liquid hydrogen pool was measured for the pressures from atmospheric to 1.1 MPa. The flat plate heater used was 10 mm in width, 100 mm in length and 0.1 mm in thickness. Critical heat fluxes (CHFs) in saturated boiling increased with the increase in pressure up to around 0.3 MPa and then decreased with further pressure increase. The CHFs under subcooled condition at each pressure increased with the increase in sub-cooling. Discussions were made on the experimental results by comparing with those of the other cryogenic liquids and also the Kutateladze’s equations under saturated and subcooled conditions. The experimental CHFs were much smaller than the Kutateladze’s equation for higher pressure up to critical. The heater surface temperature was found to reach the critical temperature before the occurrence of hydrodynamic instability and jump to the film boiling regime at the lower heat flux in the higher pressure range. It was suggested that the CHFs are determined not by the heat flux but by the temperature in the higher pressure range.     

Fabrication of ferromagnetic nanoconstriction using atomic force microscopy nanoscratching

Nanolithography used in conjunction with atomic force microscopy (AFM) has attracted considerable attention as a technique for fabricating nanoscale structures. To obtain nanostructures and devices, AFM nanoscratching was performed on a photoresist and on NiFe at various values of the applied force, scan speed, and number of scan cycles. The scratching process was carried out using a diamond-coated tip on NiFe and a Si tip on the photoresist. By conducting scratching processes on NiFe and on the photoresist, we investigated the dependence of the size of the scratched part on the scratching parameters. These results show that the width and depth of the scratched part increase as the applied force and number of scan cycles increase, but not as the scan speed increases. This means that it is possible to control the size of the scratched parts by adjusting the applied force and number of scan cycles. AFM nanoscratching was then used to directly fabricate a nanoconstricted area with a width of 139 nm and a cross-sectional area of less than 300 nm2 was fabricated.     

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Outcomes

The effect of prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) at the environmental level on birth size was examined. The concentration of 1-hydroxypyrene (1-OHP) in spot urine samples collected from 50 pregnant women in Tokyo was measured and was related to birth weight, length, and head circumference of the newborns the subjects delivered. Analysis of inter- and intra-individual variation in 1-OHP concentration in spot urine samples from non-smoking subjects revealed that single spot urine can represent the subject's exposure to PAHs over several weeks and utility of spot urine for assessing PAHs exposure level of non-smokers was indicated. Geometric mean urinary concentration of 1-OHP of the subjects was 0.056 μmol/mol creatinine, and smoking mothers (n = 7) excreted more 1-OHP (0.200 μmol/mol-cre) than non-smoking mothers (0.046 μmol/mol-cre). Multiple regression analysis using birth outcomes as the dependent variable and urinary 1-OHP and other covariates as independent variables revealed that urinary 1-OHP was not a significant variable to explain birth outcomes among non-smoking mothers.