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61.
Mikhail G. Akimov Alina M. Gamisonia Polina V. Dudina Natalia M. Gretskaya Anastasia A. Gaydaryova Andrey S. Kuznetsov Galina N. Zinchenko Vladimir V. Bezuglov 《International journal of molecular sciences》2021,22(2)
GPR55 is a GPCR of the non-CB1/CB2 cannabinoid receptor family, which is activated by lysophosphatidylinositol (LPI) and stimulates the proliferation of cancer cells. Anandamide, a bioactive lipid endocannabinoid, acts as a biased agonist of GPR55 and induces cancer cell death, but is unstable and psychoactive. We hypothesized that other endocannabinoids and structurally similar compounds, which are more hydrolytically stable, could also induce cancer cell death via GPR55 activation. We chemically synthesized and tested a set of fatty acid amides and esters for cell death induction via GPR55 activation. The most active compounds appeared to be N-acyl dopamines, especially N-docosahexaenoyl dopamine (DHA-DA). Using a panel of cancer cell lines and a set of receptor and intracellular signal transduction machinery inhibitors together with cell viability, Ca2+, NO, ROS (reactive oxygen species) and gene expression measurement, we showed for the first time that for these compounds, the mechanism of cell death induction differed from that published for anandamide and included neuronal nitric oxide synthase (nNOS) overstimulation with concomitant oxidative stress induction. The combination of DHA-DA with LPI, which normally stimulates cancer proliferation and is increased in cancer setting, had an increased cytotoxicity for the cancer cells indicating a therapeutic potential. 相似文献
62.
G. N. Fursey M. A. Polyakov A. A. Begidov I. I. Zakirov A. A. Podymsky A. A. Yakub 《Journal of Communications Technology and Electronics》2017,62(8):882-885
Principles of the development of high-power pulsed X-ray sources based on explosive emission from carbon nanoclusters are stated. Designs and main parameters of the developed X-ray tubes ( the electron flow exciting the X-ray radiation is 100?500 А, the voltage is 20?150 kV, the pulse length is 10?20 ns, and the nanosecond pulse repetition rate is 1?103 Hz) are reported. 相似文献
63.
64.
Vassiliki Damakoudi Tobias Feldner Edina Dilji Andrey Belkin Prof. Clemens Richert 《Chembiochem : a European journal of chemical biology》2021,22(5):924-930
Messenger RNA (mRNA) is emerging as an attractive biopolymer for therapy and vaccination. To become suitable for vaccination, mRNA is usually converted to a biomaterial, using cationic peptides, polymers or lipids. An alternative form of converting mRNA into a material is demonstrated that uses branched oligoribonucleotide hybrids with the ability to hybridize with one or more regions of the mRNA sequence. Two such hybrids with hexamer arms and adamantane tetraol as branching element were prepared by solution-phase synthesis. When a rabies mRNA was treated with the branched hybrids at 1 M NaCl concentration, biomaterials formed that contained both of the nucleic acids. These results show that branched oligoribonucleotides are an alternative to the often toxic reagents commonly used to formulate mRNA for medical applications. 相似文献
65.
A. N. Kalinkin V. M. Skorikov E. M. Kozhbakhteev A. E. Polyakov S. A. Kuznetsova 《Inorganic Materials》2013,49(12):1199-1202
An integrodifferential equation for skyrmions in a magnetic material is solved by the finite-difference method with allowance for Dzyaloshinskii-Moriya and dipole-dipole interactions. 相似文献
66.
67.
Andrey N. Agafonov Boris O. Volodkin Denis G. Kachalov Boris A. Knyazev Grigory I. Kropotov Konstantin N. Tukmakov 《Journal of Modern Optics》2013,60(11):1051-1054
AbstractWe demonstrate results of studies of a silicon binary diffractive optical element (DOE) focusing a terahertz laser Gaussian beam into a paraxial segment. The characteristics of the DOE were examined on a Novosibirsk Free Electron Laser beam of 141-μm wavelength. 相似文献
68.
Emmanuel Bernuau Andrey Polyakov Denis Efimov Wilfrid Perruquetti 《Systems & Control Letters》2013,62(12):1159-1167
Several conditions are proposed to check different robustness properties (ISS, iISS, IOSS and OSS) for generic nonlinear systems applying the weighted homogeneity concept (global or local). The advantages of this result are that, under some mild conditions, the system robustness can be established as a function of the degree of homogeneity. 相似文献
69.
A side-chain type benzoxazine-functional cellulose has been developed using click chemistry via the reaction of ethynyl-monofunctional benzoxazine monomer and azide-functional cellulose. The synthesis, crosslinking, and thermal properties of the benzoxazine-functional cellulose are studied by NMR, FTIR, DSC, and TGA. The crosslinking reaction of the benzoxazine side-chain unusually takes place at low-temperatures in comparison to an ordinary benzoxazine resins. Upon crosslinking, the polymer shows high char yield of 40%, which is a marked improvement from a mere 4% of the unfunctionalized cellulose. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
70.
T. N. Gerasimenko P. A. Polyakov S. I. Kasatkin V. V. Amelichev 《Automation and Remote Control》2013,74(12):2202-2208
This paper presents the results of theoretical analysis of motion control for magnetic micro- and nanobeads in a gradient magnetic field in a viscous medium. The problem considered is relevant for the design of a magnetoresistive biosensor. 相似文献