Medical technology development: limiting regulation

The medical technology industry is one of the most innovative sectors of the US economy. The paper considers how the US federal government, in a variety of roles as promoter, protector and payer, is involved in every stage of the innovative process for medical technology. It discusses the influence of government policies on medical innovation     

Cognitive impenetrability of memory for orientation.

This research produced evidence that an aspect of visual long-term memory—memory for lateral orientation of pictures—is constrained by a viewer-centered or egocentric reference frame. Subjects in Experiment 1 verbally encoded and then verbally recalled the locations of objects within scenic pictures. Recall of locations in terms of left-right directions (using a viewer-centered frame) exceeded recall of locations in terms of relative proximities to features of the room (using an environmental frame), even if the relative proximities had been verbalized at input. Subjects in Experiment 2 viewed half of a list of pictures directly and the remainder, reflected in a mirror. They then took a test in which they classified old pictures—all viewed directly— as "same-orientation" or "reversed." Performance was much better with a viewer-centered definition of same orientation (Does the picture appear the same way around?) than with an environmental definition (Is the picture the same way around on the screen?), even with forewarning of an environmental orientation test. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Management of the patient with minor traumatic brain injury

Staff in the accident and emergency department and critical care unit are often confronted with patients who have sustained life-threatening injuries. In such situations the symptoms of a minor traumatic brain injury (MTBI) may be missed. It is important that, when the physical symptoms begin to subside, nurses are aware of the symptoms of MTBI and respond accordingly. A post-concussion syndrome may develop 2 weeks to 2 months after a MTBI. This syndrome can affect the patient's ability to perform the usual activities of living. This article defines MTBI, describes the symptoms encountered in patients with MTBI, and outlines the pathophysiology, clinical findings, treatment and nursing interventions.     

Expression and localization of membrane type 1 matrix metalloproteinase in tooth tissues

Matrix metalloproteinases (MMPs) have been detected in forming dental enamel and are thought to play an important role during enamel biomineralization. Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a membrane bound member of the MMP gene family that has previously been shown to be expressed by cells associated with bone and cartilage formation (osteoclasts, osteoblasts and chondrocytes). Thus, we asked if MT1-MMP was also expressed by the cells responsible for the formation of enamel and dentin. A porcine MT1-MMP cDNA composed of 3284 bp was isolated from an enamel organ-specific cDNA library. Multiple tissue Northern blot analysis revealed that the MT1-MMP message was expressed highly in the enamel organ and pulp organ when compared to the expression levels observed in other non-mineralizing tissues. Northern blot analysis of stage-specific enamel organs (early secretory, late secretory, or maturation stage) and their corresponding pulp organs revealed that MT1-MMP expression increased as the dentin matured. In the enamel organs, however, the MT1-MMP message level became reduced only during the late secretory stage. Immunohistochemical analysis showed that MT1-MMP was present on the surface of the cells (ameloblasts and odontoblasts) responsible for dentin and enamel formation. Thus, MT1-MMP is highly expressed in developing tooth tissues and may play a role in the biomineralization of enamel and dentin.     

Efficacy of silicone punctal plugs as adjuncts to topical pharmacotherapy of glaucoma--a pilot study. Punctal Plugs in Glaucoma Study Group

BACKGROUND: The concept of enhancing the ocular hypotensive effects of topical antiglaucoma medications by impeding lacrimal drainage of medication has been insufficiently studied. This investigation sought to evaluate the effect of bilateral inferior punctal occlusion using silicone punctal plugs on the ocular hypotensive effect of topically applied timolol. METHODS: A randomized, double-masked, cross-over clinical trial was conducted, comparing the ocular hypotensive effect of timolol maleate 0.25 percent, both with and without occlusion of the inferior punctum with the Freeman silicone punctal plug. Following a 2-week washout of topical medication, 17 subjects with early primary open-angle glaucoma or ocular hypertension received one drop of timolol 0.25 percent in each eye with or without punctal plugs in place. Blood pressure, resting pulse rate, and intraocular pressure were measured both before timolol instillation and at intervals of 1, 2, 4, 8, and 12 hours following drop instillation. Following a 2-week washout period, the subjects were evaluated with the alternative treatment. RESULTS: There was no statistically significant difference (p = 0.648) in IOP levels between treatment groups. CONCLUSIONS: This pilot suggests that need for a longer-term study with larger numbers of subjects to evaluate the potential role of silicone punctal plugs to enhance the ocular bioavailability of topically applied antiglaucoma medications.     

Digital design and time on device; how aesthetic experience can help to illuminate the psychological impact of living in a digital culture

ABSTRACT

Aesthetic techniques are increasingly used by marketeers to create enticing digital products. In this paper, I work with the aesthetic experiences of one audience group to consider the psychological impact of living in a culture where digital devices are deliberately designed to influence behaviour. I argue that aesthetic encounters can help with understanding the impact of the interplay between visual stimulus, affect and digital culture, in ways that may support situated understandings of mental distress in a digital age. I show how audiences respond to the artist-led research project Are We All Addicts Now? arguing that they generate ideas connected to submersion and being overwhelmed as a means of reporting on their own personal experiences of living in a digital culture that seeks to influence behaviour. The findings may have value for designers, curators and artists invested in understanding the experiential impact of digital devices.     

Depolarization measurements of an integrating sphere

Mueller-matrix polarimetry performed in the visible and near IR indicates that an integrating sphere acts as an ideal depolarizer to the 0.5% accuracy of the polarimeter. The integrating sphere emits unpolarized light regardless of the incident polarization state.     

Production of perovskite-like La1−xCaxMnO3+δ ferromagnetic thin films by electrochemical reduction

Ferromagnetic and perovskite-like thin films (<1m) of La1–xCaxMnO3+ have been routinely prepared by heat treatment of an amorphous La–Ca–Mn precursor. The precursor was electrodeposited cathodically in the absence of oxygen and water onto polished silver substrates from a nonaqueous solution of the components' nitrates. Analysis by X-ray diffraction and SQUID magnetometry shows these materials exhibit the appropriate structural and magnetic phases indicative of colossal magnetoresistance.     

Toward Practical Smile Detection

Machine learning approaches have produced some of the highest reported performances for facial expression recognition. However, to date, nearly all automatic facial expression recognition research has focused on optimizing performance on a few databases that were collected under controlled lighting conditions on a relatively small number of subjects. This paper explores whether current machine learning methods can be used to develop an expression recognition system that operates reliably in more realistic conditions. We explore the necessary characteristics of the training data set, image registration, feature representation, and machine learning algorithms. A new database, GENKI, is presented which contains pictures, photographed by the subjects themselves, from thousands of different people in many different real-world imaging conditions. Results suggest that human-level expression recognition accuracy in real-life illumination conditions is achievable with machine learning technology. However, the data sets currently used in the automatic expression recognition literature to evaluate progress may be overly constrained and could potentially lead research into locally optimal algorithmic solutions.