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Case Study – The Making of an Institutional Crisis: The Mass Release of Inmates by a Correctional Agency 下载免费PDF全文
A US state correctional agency inadvertently released a large numbers of inmates before expiration of their sentences. This created an institutional crisis, for three reasons. First, the correctly timed release of inmates is unequivocally central the agency's core mission. Second, the early releases were consequential, in that serious crimes were committed by those only out of prison because of early release. Third, a citizen alerted the agency of an early‐release calculation for a particular offender, but the agency failed to act on this information. The correctional agency responded to this crisis by changing both its operating procedure and its culture. 相似文献
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Chongxin Yuan N.Bert Roozen Otto Bergsma Adriaan Beukers 《Engineering Analysis with Boundary Elements》2013,37(2):250-259
The aircraft fuselage is idealized as a composite cylinder, its vibroacoustic properties are studied both experimentally and numerically, and a minimization of the inner pressure of a composite cylinder is conducted with the genetic algorithm (GA). In the optimization, the Acoustic Transfer Vector (ATV), which comes from the boundary element method, builds the relationship between the structural surface velocity and the sound pressure at the specific filed points. Results show that the noise reduction obtained by the experimental and numerical methods have a good agreement; the optimization method which combines GA and ATV show high efficiency and robustness; increase of the bending stiffness of the cylinder can improve the noise reduction at low frequencies; both the reduction of weight and the increase of noise insulation can be achieved by the optimization of the layup at different regions of the cylinder individually. 相似文献
45.
Bert J. Campo David Bevk Jurgen Kesters Jan Gilot Henk J. Bolink Jun Zhao Jean-Christophe Bolsée Wibren D. Oosterbaan Sabine Bertho Jan D’Haen Jean Manca Laurence Lutsen Guy Van Assche Wouter Maes René A.J. Janssen Dirk Vanderzande 《Organic Electronics》2013,14(2):523-534
The introduction of functional moieties in the donor polymer (side chains) offers a potential pathway toward selective modification of the nanomorphology of conjugated polymer:fullerene active layer blends applied in bulk heterojunction organic photovoltaics, pursuing morphology control and solar cell stability. For this purpose, two types of poly(3-alkylthiophene) random copolymers, incorporating different amounts (10/30/50%) of ester-functionalized side chains, were efficiently synthesized using the Rieke method. The solar cell performance of the functionalized copolymers was evaluated and compared to the pristine P3HT:PCBM system. It was observed that the physicochemical and opto-electronic characteristics of the polythiophene donor material can be modified to a certain extent via copolymerization without (too much) jeopardizing the OPV efficiency, as far as the functionalized side chains are introduced in a moderate ratio (<30%) and that preference is given to side chains with a small molar volume. A range of complementary techniques – UV–Vis spectroscopy, (modulated temperature) differential scanning calorimetry, transmission electron microscopy and X-ray diffraction analysis – indicated that variations in polymer crystallinity, while maintaining a high level of regioregularity, are probably the main factor responsible for the observed differences. 相似文献
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This paper describes an algorithm that predicts the shape of material removed by a flat-end milling tool, and this may be used to compute machining strip width and scallop height at different positions of the tool path track. The algorithm computes swept sections, profiles which are swept by a moving tool bottom by passing through given planes. The technique is applicable for finish and semi-finish multi-axis milling strategies that use flat-end tools. For these strategies, the algorithm complexity can be reduced from computation of the 3D envelope of swept volumes to computation of plane-circle intersections. A new adaptive derivative-free method to sample tool motion provides robust means to generate intermediate tool positions. The step length is constrained by and dependent on different geometrical measures. At each point of a tool path, in the plane perpendicular to the cutting direction, the bottom profile of the swept section is an estimate of the profile of material left. By calculating the distance between part geometry and the computed profile of removed material, machining strip width and a scallop profile can be derived. These results can be used by tool path generation and validation routines to accurately determine the step-over between tool path tracks and surface quality. 相似文献
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Inside Cover: Site‐Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface (ChemBioChem 23/2016) 下载免费PDF全文
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Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4‐Oxalocrotonate Tautomerase More Effectively than Distant Mutations 下载免费PDF全文
Mehran Rahimi Jan‐Ytzen van der Meer Dr. Edzard M. Geertsema Harshwardhan Poddar Dr. Bert‐Jan Baas Prof. Dr. Gerrit J. Poelarends 《Chembiochem : a European journal of chemical biology》2016,17(13):1225-1228
The enzyme 4‐oxalocrotonate tautomerase (4‐OT), which catalyzes enol–keto tautomerization as part of a degradative pathway for aromatic hydrocarbons, promiscuously catalyzes various carbon–carbon bond‐forming reactions. These include the aldol condensation of acetaldehyde with benzaldehyde to yield cinnamaldehyde. Here, we demonstrate that 4‐OT can be engineered into a more efficient aldolase for this condensation reaction, with a >5000‐fold improvement in catalytic efficiency (kcat/Km) and a >107‐fold change in reaction specificity, by exploring small libraries in which only “hotspots” are varied. The hotspots were identified by systematic mutagenesis (covering each residue), followed by a screen for single mutations that give a strong improvement in the desired aldolase activity. All beneficial mutations were near the active site of 4‐OT, thus underpinning the notion that new catalytic activities of a promiscuous enzyme are more effectively enhanced by mutations close to the active site. 相似文献
49.
Staffan Jacobsson Anna Bergek Dominique Finon Volkmar Lauber Catherine Mitchell David Toke Aviel Verbruggen 《Energy Policy》2009
The recent EU Commission proposal for promoting the supply of power from renewable energy sources was originally based on a pan-European, harmonised tradable green certificate (TGC) scheme. We suggest, on the basis of a multi-disciplinary analysis, that a pan-EU TGC system is not the way forward for Europe. It is vital that the Commission (and the majority of Member States) avoids implementation of such policy designs put forward by a coalition of vested interests. They should instead look at, and act upon, the available evidence from those countries that have experimented with TGCs (e.g. Flanders, UK and Sweden) and design policies that stand a better chance of meeting the criteria of effectiveness, efficiency and equity. In particular, the policies must enable EU to meet the immense innovation/industrialisation challenge by inducing the development of a capital goods industry that can, eventually, diffuse a broad range of technologies that use renewable energy sources. Only then we can acquire an ability to implement an industrial revolution in the energy system in a way that broadly meets the criteria of effectiveness and dynamic efficiency. 相似文献
50.
Zandra Arwidsson Kristin Elgh-Dalgren Thomas von Kronhelm Ragnar Sjöberg Bert Allard Patrick van Hees 《Journal of hazardous materials》2010,173(1-3):697-704
Removal of Cu, Pb, and Zn by the action of the two biodegradable chelating agents [S,S]-ethylenediaminedisuccinic acid (EDDS) and methylglycinediacetic acid (MGDA), as well as citric acid, was tested. Three soil samples, which had previously been treated by conventional soil washing (water), were utilized in the leaching tests. Experiments were performed in batches (0.3 kg-scale) and with a WTC-mixer system (Water Treatment Construction, 10 kg-scale). EDDS and MGDA were most often equally efficient in removing Cu, Pb, and Zn after 10–60 min. Nonetheless, after 10 d, there were occasionally significant differences in extraction efficiencies. Extraction with citric acid was generally less efficient, however equal for Zn (mainly) after 10 d. Metal removal was similar in batch and WTC-mixer systems, which indicates that a dynamic mixer system could be used in full-scale. Use of biodegradable amino polycarboxylic acids for metal removal, as a second step after soil washing, would release most remaining metals (Cu, Pb and Zn) from the present soils, however only after long leaching time. Thus, a full-scale procedure, based on enhanced metal leaching by amino polycarboxylic acids from soil of the present kind, would require a pre-leaching step lasting several days in order to be efficient. 相似文献