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针对谱聚类融合模糊C-means(FCM)聚类的蛋白质相互作用(PPI)网络功能模块挖掘方法准确率不高、执行效率较低和易受假阳性影响的问题,提出一种基于模糊谱聚类的不确定PPI网络功能模块挖掘(FSC-FM)方法。首先,构建一个不确定PPI网络模型,使用边聚集系数给每一条蛋白质交互作用赋予一个存在概率测度,克服假阳性对实验结果的影响;第二,利用基于边聚集系数流行距离(FEC)策略改进谱聚类中的相似度计算,解决谱聚类算法对尺度参数敏感的问题,进而利用谱聚类算法对不确定PPI网络数据进行预处理,降低数据的维数,提高聚类的准确率;第三,设计基于密度的概率中心选取策略(DPCS)解决模糊C-means算法对初始聚类中心和聚类数目敏感的问题,并对预处理后的PPI数据进行FCM聚类,提高聚类的执行效率以及灵敏度;最后,采用改进的边期望稠密度(EED)对挖掘出的蛋白质功能模块进行过滤。在酵母菌DIP数据集上运行各个算法可知,FSC-FM与基于不确定图模型的检测蛋白质复合物(DCU)算法相比,F-measure值提高了27.92%,执行效率提高了27.92%;与在动态蛋白质相互作用网络中识别复合物的方法(CDUN)、演化算法(EA)、医学基因或蛋白质预测算法(MGPPA)相比也有更高的F-measure值和执行效率。实验结果表明,在不确定PPI网络中,FSC-FM适合用于功能模块的挖掘。 相似文献
53.
Yue Gao Miao-miao Zhang Xiao-peng Guo Wen-jian Li Dong Lu 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2020,95(5):1290-1297
Toxicity caused by the accumulation of butanol in fermentation media is an important factor limiting the concentration of butanol. There is currently no systematic research in place investigating the butanol tolerance mechanism of bacteria such as Clostridium acetobutylicum, which adapts to butanol stress and regulates its growth and metabolism. Here, research results related to the butanol tolerance of C. acetobutylicum are reviewed to understand the molecular basis of changes in butanol-tolerant strains. Organic solvent-tolerant bacteria play an important role in the fields of biofuel production, enzyme preparation and bioremediation. An analysis of limitations of the application of organic solvent-tolerant bacteria has revealed that future research should focus on combining the microbial tolerance phenotype with specific utilization to achieve an optimal balance between organic solvent tolerance and production. This review serves as a reference for the improvement and engineering of strains that tolerate organic solvents. © 2019 Society of Chemical Industry 相似文献
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Zhuo Wang Haonan Chen Tian Wang Yujia Xiao Wenwen Nian Jiahao Fan 《Journal of the European Ceramic Society》2018,38(11):3847-3852
The appearance of colossal permittivity materials broadened the choice of materials for energy-storage applications. In this work, colossal permittivity in ceramics of TiO2 co-doped with niobium and europium ions ((Eu0.5Nb0.5)xTi1-xO2 ceramics) was reported. A large permittivity (εr ~ 2.01?×?105) and a low dielectric loss (tanδ ~ 0.095) were observed for (Eu0.5Nb0.5)xTi1-xO2 (x?=?1%) ceramics at 1?kHz. Moreover, two significant relaxations were observed in the temperature dependence of dielectric properties for (Eu, Nb) co-doped TiO2 ceramics, which originated from defect dipoles and electron hopping, respectively. The low dielectric loss and high relative permittivity were ascribed to the electron-pinned defect-dipoles and electrons hopping. The (Eu0.5Nb0.5)xTi1-xO2 ceramic with great colossal permittivity is one of the most promising candidates for high-energy density storage applications. 相似文献
58.
The increased concentration of CO2 due to continuous breathing and no discharge of human beings in the manned closed space, like spacecraft and submarines, can be a threat to health and safety. Effective removal of low concentration CO2 from the manned closed space is essential to meet the requirements of long-term space or deep-sea exploration, which is an international frontier and trend. Ionic liquids (ILs), as a widespread and green solvent, already showed its excellent performance on CO2 capture and absorption, indicating its potential application in low concentration CO2 capture. In this review, we first summarized the current methods and strategies for direct capture from low concentration CO2 in both the atmosphere and manned closed spaces. Then, the multi-scale simulation methods of CO2 capture by ionic liquids are described in detail, including screening ionic liquids by COSMO-RS methods, capture mechanism by density functional theory and molecular dynamics simulation, and absorption process by computational fluid dynamics simulation. Lastly, some typical IL-based green technologies for low concentration CO2 capture, such as functionalized ILs, co-solvent systems with ILs, and supported materials based on ILs, are introduced, and analyzed the subtle possibility in manned closed spaces. Finally, we look forward to the technology and development of low concentration CO2 capture, which can meet the needs of human survival in closed space and proposed that supported materials with ionic liquids have great advantages and infinite possibilities in the vital area. 相似文献
59.
Zhuo Shi Ningning Dong Dingfeng Zhang Xiaofang Jiang Guanxin Du Shichao Lv Jiejie Chen Jun Wang Shifeng Zhou 《Journal of the American Ceramic Society》2019,102(7):3965-3971
The construction of nonlinear optical materials featuring asymmetric transmission of light is of great technological importance for various applications, including optical switching and optical power limiting. A significant challenge is the scalable fabrication of material candidates with good photochemical stability, high optical transmittance, and excellent optical limiting performance. Here, we present a nanocrystallization avenue for constructing hybrid optical limiting materials that exhibit ultrafast and robust optical limiting performance. The experimental results show that the controllable relaxation of a niobate glass may lead to the clustering of Nb-O units and contracting of the bandgap. It results in the notable improvement in nonlinear optical properties, including the enhanced saturation irradiance (380 GW/cm2), doubly increased nonlinear coefficient, and decreased limiting threshold (200 GW/cm2). Our results suggest a promising material that exhibits promising applications for protecting eyes and sensitive components from laser-induced damage. 相似文献
60.
棋盘格图像在摄像机标定中有非常广泛的应用,对于复杂环境且测量精度要求非常高的场合,会需要特定的且有一定复杂度的算法,但通常情况下,使用这样的标定系统是没有必要的,且会让初次应用的人觉得困难。这里提供一套应用简单,快速,对棋盘格图像具有旋转不变性,良好的鲁棒性,且对非复杂环境具有高精度的标定系统。所有算法均是在前辈们的算法上稍作改变而来,应用效果非常好。 相似文献