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51.
This paper brings into focus the topological and geographical evaluation of metro networks through the definition of a methodological approach based on a set of indicators, a lot of which are defined in the sector literature. Once the methodology was stated, the results of an application on the metro networks of 13 big metropolitan areas were illustrated. Statistical comparative analyses are proposed to classify networks.  相似文献   
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The prime characteristic of spread spectrum modulated signals is that their bandwidth is greater than the information rate. In this way a redundancy is introduced that allows the severe levels of inteference inherent in the transmission of digital information over radio and satellite links to be overcome. Current spread spectrum applications are primarily in military communications; nevertheless, there is growing interest in this technique for third generation mobile radio networks (UMTS, FPLTS, etc.) with open discussion regarding the practicality of using a multiple access system based on spread spectrum techniques (CDMA). However, in order to support as many users in the same bandwidth as other multiple access techniques such as TDMA or FDMA, it is important how to generate large families of sequences that present low cross-correlation. The aim of this paper is to describe a spreading codes generator that can produce a large number of PN sequences with good properties of auto- and cross-correlation. Moreover, the codes generated shows high unpredictability and good statistical behaviour. This also allows the implementation of some features that are common on military networks such as message privacy (increasingly important in commercial networks) without additional cost. The structure presented shows itself to be advantageous for high speed generation of codes at a low cost, low power consumption (allowing longer life for batteries), small size and simplicity of implementation, essential ingredients for commercial equipment. Another attractive feature is its structural parallelism, useful in VLSI implementations. All of these features render it potentially suitable for the implementation of channel bandwidth sharing systems in future wireless personal communications networks.  相似文献   
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The article describes a system for hypothesis elicitation and ranking formed by a net of computational elements obtained by modifying the classical neural model of Caianiello. This neural structure was chosen on the basis both of knowledge representation and of parallel processing considerations. the two fundamental components of the system are an elaboration layer and, in case the available evidences are insufficient to trigger explanatory hypotheses, a query layer that enables the system to gather additional information. Algorithms that help setting the crucial variable parameters of the net are described in the Appendix. © 1992 John Wiley & Sons, Inc.  相似文献   
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The adoption of Nature-inspired strategies to improve materials has fostered the introduction of cavities. But how to mass-produce structures in which a complex architecture of cavities is point-to-point fine-tuned to the local and global application requirements? To this aim, the use of a procedure based on topology optimization and gas foaming is herein reported. As an example case, a polymeric foamed beam whose density map is optimized in 3D for three-point bending is designed and produced by gas foaming a purpose-designed preform. The preform is produced with polypropylene and by a high pressure autoclave with CO2 as blowing agent. Optical and scanning electron microscopy as well as X-ray microscopy are used to analyze the 3D optimized foamed structures and show the effectiveness of the foaming design protocol in producing the finite element method-optimized structures. A remarkable twofold increase in the stiffness of the optimized structures is measured with respect to that of the uniformly foamed counterpart with equal overall mass. With the use of a single recyclable material in a single processing step, this method allows one to conceive the mass production of optimized, therefore more sustainable, plastic parts.  相似文献   
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The treatment of diabetic wound remains a big clinical challenge. Hydrogel that can provide physical barrier and humidity displays amazing potentials for managing the diabetic wounds healing. Herein, a new charge-driven self-assembled microsphere hydrogel scaffold (SMHS) is reported based on an electric charge interaction, by combining use of black phosphorus (BP)-contained chitosan methacryloyl (CS) microspheres with positive charge and basic fibroblast growth factor-contained hyaluronic acid methacryloyl (HA) microspheres with negative charge. The weak charge attraction among microspheres gives the SMHS the injectable characteristic. Due to the existence of BP, near-infrared (NIR) irradiation has obvious effects on the degradation and drug release behaviors of SMHS. Significantly, SMHS that combines the short-term physical (photothermal) intervention and long-term chemical (drug release) intervention may be promising in spatio-temporal regulation of regenerative microenvironment. SMHS with NIR irradiation (SMHS+NIR) can promote cell proliferation, cell migration, angiogenesis and macrophage polarization. Moreover, in diabetic rat skin wounds, SMHS+NIR significantly accelerates the wound healing process by simultaneously inhibiting the inflammatory response, promoting angiogenesis and tissues remodeling. The outcome of this research not only provides a biomaterial for diabetic wounds healing, but also demonstrates a new strategy for designing novel hydrogel-based biomaterials which have the free editing and combination functions.  相似文献   
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Ubiquitin (Ub) proteoforms control nearly every aspect of eukaryotic cell biology through their diversity. Inspired by the widely used Ub C-terminal electrophiles (Ub−E), here we report the identification of multivalent binding of Ub with deubiquitylating enzymes (Dubs) using genetic code expansion (GCE) and crosslinking mass spectrometry. While the Ub−Es only gather structural information with the S1 Dub sites, we demonstrate that GCE of Ub with p-benzoyl-L-phenylalanine enables identification of interaction modes beyond the S1 site with a panel of Dubs of both eukaryotic and prokaryotic origin. Collectively, this represents the next generation of Ub-based affinity probes with a unique ability to unravel Ub interaction landscapes beyond what is afforded by cysteine-based chemistries.  相似文献   
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Chlorine dioxide has been historically used as a disinfecting agent for drinking water supplies and surfaces. Widespread use as an alternative option for prevention and treatment of COVID-19 has emerged due to a lack of specific treatment. We present the case of a 55-year-old male who developed acute kidney injury and disseminated intravascular coagulation after chlorine dioxide prophylactic ingestion, with regression after therapy with hemodialysis.  相似文献   
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