Irrigation Modelling in the Context of Basin Water Resources

Management practices for irrigation schemes can often be improved by modelling the behaviour of a scheme and by evaluating its efficiency statistics. However, looking at an irrigation scheme without regard for other water uses within the river basin may not be effective. Efficiencies computed in this way are local and, since water may be used many times within the same basin, may not be realistic. Changes in water uses (e.g. irrigation, industrial, power production, urban water supply, navigation, environmental, recreational) will often have effects on other uses; and changes in irrigation schemes (management,structural, crop pattern) may affect other users within the basin. In addition, all water users will be affected by external changes such as changes in land cover or in climate. As demand for water increases, these links become more important until, at some stage, there is insufficient water for all users and hard choices must be made. Hydrological modelling is a tool that can be used to relate irrigation schemes to the other water uses within a river basin and can help in assessing real productivities and in evaluating alternative patterns of water usage. This paper discusses the techniques available to simulate irrigation schemes within overall basin water resources using, as an example, an intensively utilized basin in western Turkey.     

Serum amyloid P component scintigraphy and turnover studies for diagnosis and quantitative monitoring of AA amyloidosis in juvenile rheumatoid arthritis

OBJECTIVE: To evaluate aspects of the natural history of AA amyloidosis complicating juvenile rheumatoid arthritis (JRA), and its response to therapy with chlorambucil. METHODS: Scintigraphy and 7-day turnover studies were performed in JRA patients with histologically proven (n = 35) or clinically suspected (n = 30) AA amyloidosis, following intravenous injection of 123I and 125I-labeled serum amyloid P component (SAP). Prospective monitoring studies were performed over 2-3 years in 20 patients with amyloidosis. All but 2 amyloidosis patients were treated with chlorambucil. RESULTS: Positive scanning results were obtained in all patients in whom imaging was performed within 12 years of positive biopsy findings of amyloid and in 5 patients with clinically suspected amyloidosis. Negative scanning results with normal SAP metabolism, indicating regression of amyloid, were obtained in 4 patients whose amyloidosis had been in full clinical remission for more than 12 years. Prospective monitoring studies in patients whose JRA-associated inflammatory activity was in remission demonstrated regression of amyloid in 8 patients and no substantial changes in 8 others; however, in 4 further patients with active inflammation, there was accumulation of amyloid. There was a very poor correlation between the amount of amyloid present at a particular site and the resultant organ dysfunction. CONCLUSION: Radiolabeled SAP scintigraphy and turnover studies are useful complementary tools in the diagnosis, screening, and quantitative monitoring of type AA amyloidosis in JRA. The amyloid deposits may progress and/or regress at different rates in different anatomic sites over short periods.     

The science-industry interface: Correlation of time series of indicators and their spectra,and growth models in the nuclear fuels industry

This paper is the third in a series on the flows of influence at the interface between geoscience research and the exploration for and mining of nuclear fuels. It deals with the application of signal processing methods to research and industry indicators, with emphasis on time and frequency domain correlations and lags, and on growth modelling of the indicators using the special and general logistic models. The findings include the following: there was a strong interchange across the science-industry interface; quantitative methods can establish the degree of correlation and the time periods in which these correlations mainly reside; also the timing of decisions to initiate exploration and research can be specified in this case. A strategy of applying quantitative methods, history of science, and periodic analyses of the state of the industry to studies of science policy is suggested by this research.     

Excited-state-absorption cross sections and amplifier modeling inthe 1300-nm region for Nd-doped glasses

The performance of Nd³⁺-doped fibre amplifiers is limited by strong excited-state absorption (ESA) of the signal, and, even for fluorozirconate glasses, ESA prevents the important region below 1320 nm from being used. To quantify this limitation and explore alternative host materials, ESA and stimulated-emission cross sections have been measured for a representative group of glass compositions. These parameters have been used in an accurate fiber-amplifier model to provide the first quantitative comparisons of performance for Nd³⁺ -doped glasses in the 1300-nm band as a function of host     

Revisiting the nonplace Urban Realm: Have we come full circle?

Melvin Webber's seminal papers of 1963/64, which posited the arrival of a Nonplace Urban Realm and called upon planners to abandon their obsession with space, have proved highly prescient: metropolitan areas have deconcentrated and spread as he suggested, and the arrival of the informational age further reinforces these trends by creating a spaceless economy. But urban agglomeration economies do continue to operate, and traditional urban nodes will remain important in the new space‐economy.     

Thymosin beta-10 accelerates apoptosis

The 5 Kd (MW), retinoic acid responsive thymosin beta-10 protein is expressed at relatively high levels in embryonic tissues, and its mRNA is abundant in a variety of tumors and tumor cell lines. Recently this protein (together with other members of the same protein family) was found to be a major intracellular G-actin binding protein. In the present study, plasmid-driven overexpression of thymosin beta-10 gene results in increased susceptibility of permanently transfected fibroblasts to undergo apoptosis. Conversely, knockout of the endogenous gene via overexpression of the antisense mRNA inhibited cell death induced by TNF-alpha and calcium ionophore A23187. Differential expression of thymosin beta-10 influenced cell proliferation, cell morphology, and expression/distribution of the antiapoptotic protein bcl-2. The presence of increased cytoplasmic thymosin beta-10 precipitated significant disruption of phalloidin-stained actin stress fibers while knockout of thymosin expression promoted F-actin assembly. These and other observations suggest that thymosin beta-10 (a) plays a significant and possibly obligatory role in cellular processes controlling apoptosis possibly by acting as an actin-mediated tumor suppressor, (b) perhaps functions as a neoapoptotic influence during embryogenesis, and (c) may mediate some of the pro-apoptotic anticancer actions of retinoids.