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21.
Two deacetyl-thymosin β4 analogues containing Phe(4Br) or D-Phe(4Br) as position 12 were synthesized by the manual solid-phase method, and their immunological effects on the impaired blastogenic response of phytohemagglutinin-stimulated T lymphocytes of uremic patients with infectious diseases were studied. Bromination of the p-position of Phe12 resulted in a marked restorative effect on the impaired blastogenic response of T lympocytes compared with that of our synthetic deacetyl-thymosin β4 The synthetic [Phe(4Br)12]deacetyl-thymsin β4 was approximately equal in potency to our synthetic [Phe(4F)12]deacetyl-thymosin β4 in uremic patients, but the other analogue, [D-Phe(4Br)12]deacetyl-thymosin β4, had no effect. 相似文献
22.
S Maruyama T Kurosaki K Sada Y Yamanashi T Yamamoto H Yamamura 《Canadian Metallurgical Quarterly》1996,271(12):6631-6635
Human leukemic cell line K562 is induced to differentiate into the megakaryocytic lineage by stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA). We demonstrate here that TPA stimulation increases tyrosine phosphorylation of an 80-kDa protein at an early stage of megakaryocytic differentiation and that this 80-kDa protein is identical with cortactin. Since tyrosine kinase Syk was activated by TPA stimulation, we examined the possibility that cortactin is a potential substrate of Syk in K562 cells. TPA-induced tyrosine phosphorylation of cortactin was decreased profoundly by overexpression of dominant-negative Syk. Furthermore, cortactin was associated with Syk even before TPA stimulation. Since cortactin was previously referred as an 80/85-kilodalton pp60src substrate, we examined the association between Src and cortactin, whereas its association could not be detected. These data suggest that Syk phosphorylates cortactin in K562 cells upon TPA treatment. 相似文献
23.
24.
The oxidation of Fe(II) with dissolved molecular oxygen was studied in sulfuric acid solutions containing 0.2 mol . dm-3 FeSO4 at temperatures ranging from 343 to 363 K. In solutions of sulfuric acid above 0.4 mol . dm-3, the oxidation of Fe (II) was found to proceed through two parallel paths. In one path the reaction rate was proportional
to both [Fe2+]2 and po2, exhibiting an activation energy of 51.6 . kJ mol-1. In another path the reaction rate was proportional to [Fe2+]2, [SO4-], and po2 with an activation energy of 144.6 kJ . mol-1. A reaction mechanism in which the SO4- ions play an important role was proposed for the oxidation of Fe(II). In dilute solutions of sulfuric acid below 0.4 mol
. dm-3, the rate of the oxidation reaction was found to be proportional to both [Fe(II)]2 and Po2, and was also affected by [H+] and [SO2-
4]. The decrease in [H+] resulted in the increase of reaction rate. The discussion was further extended to the effect of Fe (III) on the oxidation
reaction of Fe (II). 相似文献
25.
Manipulation of Micro Solid Particles and Induced Flows in Water by Laser Irradiation 总被引:1,自引:0,他引:1
Q-switch for pulsing laser beam and Galvano scanner for rapid scanning laser beam were adapted to manipulatemicro solid particles in a water droplet.The trapping of fine particles at micron-sized diameters by a YAG lasersystem,induced flows,and the induced motion of the particles by laser beam irradiations are discussed.Particlerotations are observed by using anisotropic micro objects,and moreover the rotational rate with clockwise direc-tion is 22 r/min.The fragments of a cover glass were mixed in a water droplet,and their size and shape are un-even.The rotation of that non-spheres without scanning by the Galvano scanner is also observed in water. 相似文献
26.
Takaki K. Kise T. Maruyama K. Yamanaka N. Funabashi A. Kasukawa A. 《Electronics letters》2002,38(23):1441-1443
Investigation of the correlation between longitudinal photon density distribution and spectral linewidth re-broadening, in conjunction with carefully designed coupling optics, enable laser modules that simultaneously achieve very high fibre-coupled power of 175 mW and very narrow linewidth<1 MHz even at /spl sim/120 mW of output power to be successfully fabricated. 相似文献
27.
Tomoko Akai Hiroshi Yamanaka Hajimu Wakabayashi 《Journal of the American Ceramic Society》1996,79(4):859-864
Copper-ruby glasses were prepared by the sputtering method and the effect of reducing treatment was examined. The reducing was carried out either during sputtering or heat treatment. Optical absorption was related to the growth of copper particles. The results are summarized as follows: (i) the volume fraction of copper particles in the glasses which are heat-treated in air increases with the addition of hydrogen in the sputtering gas. (ii) The copper particles do not grow larger than 8 nm by heat treatment in reducing atmosphere, whereas they grow as large as 12 nm in air. (iii) Reducing during heat treatment gives a pronounced effect only when sputtering was not carried out under reducing conditions. The origin of these phenomena was also discussed, considering the mechanism of nucleation and growth of copper particles. 相似文献
28.
A molecular orbital approach to materials design has recently made great progress. This approach is based on the electronic structure calculations by the DV-Xα cluster method. In this paper recent progress in this approachis reviewed. In particular 相似文献
29.
Highly transparent cellulose hydrogels with physical crosslinkage were prepared from nonaqueous organic cellulose solutions and viscose by coagulating and regenerating cellulose in an aqueous solution containing a water‐miscible organic solvent. Nonaqueous organic cellulose solutions used were LiCl/dimethylacetamide, paraformaldehyde/dimethyl sulfoxide, and triethylammonium chloride/dimethyl sulfoxide. Preparation conditions and physical properties of the transparent cellulose hydrogels were studied. The transparency of the cellulose hydrogels depended on the composition of the aqueous solution containing the organic solvent. Furthermore, transparent cellulose hydrogels from viscose showed high tensile strength. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 3020–3025, 2003 相似文献
30.
Kyoko Kawagishi Hiroshi Harada Akihiro Sato Atsushi Sato Toshiharu Kobayashi 《JOM Journal of the Minerals, Metals and Materials Society》2006,58(1):43-46
The fourth-generation nickel-based single-crystal superalloys, which contain large amounts of refractory metals for strengthening
and platinum group metals for topologically close-packed phase prevention, show excellent high-temperature strength. However,
these alloying elements seem to decrease high-temperature oxidation resistance. In this study, nickel-based superalloys with
various amounts of tantalum, rhenium, and ruthenium were examined in isothermal and cyclic exposures at 1,100°C to investigate
the effect on the oxide growth rate and resistance to scale spallation. Ruthenium and rhenium were found to degrade the oxidation
resistance by the vaporization of their oxide. Tantalum-rich oxide in the spinel layer acts to stabilize ruthenium and rhenium
oxide in the scale. The addition of hafnium and yttrium is effective in improving the oxidation resistance of ruthenium-containing
nickel-based superalloys. 相似文献