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排序方式: 共有6102条查询结果,搜索用时 828 毫秒
61.
OE Santana Rodríguez ML Malé Gil JF HernándezSantana JM Limi?ana Ca?al AM Martín Sánchez 《Canadian Metallurgical Quarterly》1998,14(6):555-561
Von Hippel-Lindau disease (VHL) is an autosomal dominant tumour syndrome caused by germline mutations of the VHL tumour suppressor gene located on chromosome 3p25-26. In VHL tumours may occur in 14 different target organs, including the eye. Retinal angiomas are considered the first manifestation of VHL disease in 43% of cases, and the cumulative probability of developing a retinal angioma in one or both eyes rises during each decade of life, reaching 80% for patients over 80 years old. Since 1976 patients with VHL at the University Hospital of Utrecht and their at-risk relatives have been screened periodically by a multidisciplinary team. Long-term follow-up ophthalmological data were analysed with special attention to natural course and results of treatment. In addition, we looked for a genotype-phenotype correlation. Retinal angiomas were found in all families. In one large family with a missense mutation (V170D) of the VHL gene, in which the complete spectrum of visceral- and central nervous system (CNS) features of VHL is present, macular, parapapillary, optic disc and ora serrata angiomas were also found. In general, however, a clear-cut genotype-phenotype correlation could not be found. Only early detection and treatment of peripheral retinal angiomas can be expected to decrease the percentage of patients with decreased visual acuity. Therefore, early detection and treatment of these tumours is of paramount importance. Ophthalmological screening of patients and persons at risk should start as early as possible. In patients with apparently sporadic retinal angiomas it is advisable to perform germline DNA analysis, since the risk of developing VHL is high, especially if the angiomas are bilateral, or unilateral and multifocal, if the patient is young, or if there is a family history suggestive of VHL. 相似文献
62.
MP Amador Rodríguez A Artal Cortés E Rebollar Torres A Idoipe Tomás P Palomo Palomo J Martínez Trufero 《Canadian Metallurgical Quarterly》1998,13(4):198-204
A B16 melanoma-specific CD8+ T cell line (AB1) was established from the spleen cells of C57BL/6 mice cured of B16 melanoma with interleukin (IL)-12 treatment. The AB1 line exclusively used T cell receptor Vbeta11. The AB1 cells exhibited a cytolytic activity against both syngeneic B16 melanoma and allogeneic P815 mastocytoma, whereas a cold inhibition assay revealed specificity of the AB1 cells against B16 melanoma. Their lostability to kill a class I loss variant of B16 melanoma was restored by the transfection of H-2Kb gene. In addition, their interferon (IFN)-gamma production was significantly suppressed by the addition of anti-H-2Kb monoclonal antibody, and RT-PCR analysis showed that the AB1 line expressed the mRNA encoding IFN-gamma, but not IL-4 or IL-10. The experiment using synthetic peptides of tyrosinase-related protein-2 (TRP-2) revealed that the AB1 cells could recognize TRP-2(181-188) peptide. Moreover, the AB1 cells showed an in vivo antitumor effect against established pulmonary metastases of B16 melanoma. Overall, these results indicate that the Tc1-type Vbeta11+ AB1 cells exert an antitumor activity against syngeneic B16 melanoma through recognition of TRP-2(181-188) peptide in an H-2Kb-restricted manner. 相似文献
63.
JR García Fernández MA montalbán ML Martín MC Ortiz MA Martínez A García Marcilla 《Canadian Metallurgical Quarterly》1998,43(5):430-432
Acute nonoliguric renal failure developed in a 13-year-old girl, 1 month after the institution of isoniazid therapy because of a positive tuberculin test at school screening. A renal biopsy demonstrated severe crescentic glomerulonephritis with focal interstitial changes. Discontinuation of isoniazid and a short course of steroids and cyclophosphamide therapy were followed by complete recovery. Whereas isoniazid has been shown to induce a lupus-like syndrome and antihistone antinuclear antibodies, our patient displayed none of the clinical or immunological features that are characteristic of drug-induced lupus. Furthermore, none of the identifiable causes for crescentic glomerulonephritis was evident in this girl. To the best of our knowledge this is the first report suggesting a possible association of crescentic glomerulonephritis to isoniazid treatment. 相似文献
64.
RM Mu?oz LA Pulpón M Yebra J Segovia M San Martín C Salas 《Canadian Metallurgical Quarterly》1998,17(11):801-806
The fibrinolytic capacity of patients with acute myocardial infarction (AMI) is known to be impaired. The primary regulatory element of the fibrinolytic system is plasminogen activator inhibitor (PAI). It has been previously observed that there are 2 peaks in the plasma PAI level of AMI patients at 4h and 16h after thrombolytic therapy with recombinant tissue plasminogen activator (rtPA). Lanoteplase/SUN9216 is a mutant tPA with a biological half-life longer than that of rtPA. Thrombolytic therapy with mutant tPA or rtPA was carried out consecutively in 21 patients with AMI (8 patients as the mutant tPA group, and 13 patients as the rtPA group). The recanalization time of the mutant tPA group was significantly faster than that of the rtPA group (16.1 +/- 3.9 min vs 39.6 +/- 4.8 min, p<0.01). The PAI activity at 4h after the initiation of thrombolysis was significantly lower in the mutant tPA group than in the rtPA group (8.74 +/- 5.46IU/L vs 26.74 +/- 3.35 IU/L, p<0.01). There was a one mild peak in serial plasma PAI activity levels 24h after the initiation of thrombolysis. The results suggest that thrombolytic therapy with mutant tPA reduced the impairment of fibrinolytic capacity. The mutant tPA gives faster recanalization and lower PAI activity after successful thrombolysis, compared with rtPA. 相似文献
65.
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67.
This study was designed to examine whether cyclosporine (CyA) acts on the endocrine system by modifying the pulsatile secretion pattern of prolactin and LH. Both pituitary-grafted and sham-operated rats were submitted to a subcutaneous vehicle or CyA (5 mg/kg) treatment daily for 10 days beginning on the day of surgery. Pituitary grafting and/or CyA administration changed the pulsatile pattern of prolactin observed in sham-operated animals. The mean values of serum prolactin were significantly increased by pituitary grafting and the treatment with CyA further increased them. The mean half-life of prolactin was significantly increased in pituitary-grafted rats and was not changed by CyA administration, although it was decreased in sham-operated rats. The frequency of prolactin pulses was significantly decreased in pituitary-grafted as compared to sham-operated controls and was not further modified by CyA administration. However, in sham-operated rats a significant decrease of this parameter was observed. Duration of the prolactin peaks was significantly increased by pituitary grafting, and was not modified by CyA administration in any of the groups studied. The absolute amplitude of the prolactin peaks was significantly increased in pituitary-grafted as compared to sham-operated animals, and the treatment with CyA further increased this parameter in both groups. Mean values of LH were significantly increased in pituitary-grafted as compared to control rats. CyA administration significantly increased LH levels in sham-operated rats and decreased them in pituitary-grafted animals. The mean half-life, the pulse frequency and the duration of LH peaks were not modified by either pituitary grafting or CyA administration.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
68.
López-Robles J. R. Cobo M. J. Gutiérrez-Salcedo M. Martínez-Sánchez M. A. Gamboa-Rosales N. K. Herrera-Viedma E. 《Applied Intelligence》2021,51(9):6547-6568
Applied Intelligence - Applied Intelligence is one of the most important international scientific journals in the field of artificial intelligence. From 1991, Applied Intelligence has been oriented... 相似文献
69.
Palomares Iván Martínez-Cámara Eugenio Montes Rosana García-Moral Pablo Chiachio Manuel Chiachio Juan Alonso Sergio Melero Francisco J. Molina Daniel Fernández Bárbara Moral Cristina Marchena Rosario de Vargas Javier Pérez Herrera Francisco 《Applied Intelligence》2021,51(9):6497-6527
Applied Intelligence - The17 Sustainable Development Goals (SDGs) established by the United Nations Agenda 2030 constitute a global blueprint agenda and instrument for peace and prosperity... 相似文献
70.
José M. Cecilia José M. García Ginés D. Guerrero Miguel A. Martínez-del-Amor Mario J. Pérez-Jiménez Manuel Ujaldón 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2012,16(2):231-246
Membrane Computing is a discipline aiming to abstract formal computing models, called membrane systems or P systems, from the structure and functioning of the living cells as well as from the cooperation of cells in tissues, organs, and
other higher order structures. This framework provides polynomial time solutions to NP-complete problems by trading space
for time, and whose efficient simulation poses challenges in three different aspects: an intrinsic massively parallelism of
P systems, an exponential computational workspace, and a non-intensive floating point nature. In this paper, we analyze the
simulation of a family of recognizer P systems with active membranes that solves the Satisfiability problem in linear time
on different instances of Graphics Processing Units (GPUs). For an efficient handling of the exponential workspace created
by the P systems computation, we enable different data policies to increase memory bandwidth and exploit data locality through
tiling and dynamic queues. Parallelism inherent to the target P system is also managed to demonstrate that GPUs offer a valid
alternative for high-performance computing at a considerably lower cost. Furthermore, scalability is demonstrated on the way
to the largest problem size we were able to run, and considering the new hardware generation from Nvidia, Fermi, for a total
speed-up exceeding four orders of magnitude when running our simulations on the Tesla S2050 server. 相似文献