In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements

This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.     

FIDAS: Detailed subchannel analysis code based on the three-fluid and three-field model

The Film Dryout Analysis Code in Subchannels, FIDAS, has been developed with the main objective of predicting dryout and post-dryout heat transfer in a channel and in rod bundles. In FIDAS, two-phase flow consisting of continuous liquid film, continuous vapor and entrained droplets is modeled by a three-fluid, three-field representation of 12 field equations, i.e. three continuity, three energy and six momentum equations. FIDAS can predict dryout without any empirical CHF correlations by introducing annular flow modeling and the ‘film dryout criterion’. Experiments on film flow characteristics, subchannel flow and enthalpy distributions, dryout and post-dryout heat transfer in tubes and rod bundles were analyzed to demonstrate the performance of FIDAS. The predictions of FIDAS are in close agreement with the experiments.     

Tacrine inhibits nicotinic secretory and current responses in adrenal chromaffin cells

Previous studies have demonstrated an infiltration of monocytes and increased levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the asthmatic lung. To study the possible effects of this cytokine upon the differentiation and function of these newly recruited monocytes, we have developed a model in which monocytes isolated from human peripheral blood were differentiated into macrophages in serum in the presence or absence of GM-CSF. After 7 days, the macrophages increased in size and granularity, had increased phagocytic activity, and expressed various adhesion molecules, CD14 and major histocompatibility complex (MHC) class II. The effects of GM-CSF on antigen presentation by cultured macrophages on the antigen-specific proliferative response of CD4+ T cells to Dermatophagoides pteronyssinus or purified protein derivative of tuberculin and the mitogen phytohaemagglutinin was determined. CD4+ T-cell proliferation was reduced when either antigen was presented by macrophages cultured in serum alone, compared with the values obtained with freshly isolated monocytes. However, CD4+ cell proliferation was comparable to that observed with monocytes when antigen was presented by macrophages which had been pre-cultured with 50 U/ml GM-CSF. CD4+ T-cell proliferation to phytohaemagglutinin was similar when all three populations were used as accessory cells. High numbers of macrophages partially suppressed CD4+ T-cell proliferation in response to antigen presented by monocytes, but there was no significant difference between macrophages cultured in the presence or absence of GM-CSF. This data suggests that GM-CSF directs monocyte differentiation into macrophages with an antigen-presenting, rather than a suppressive, phenotype. Elevated levels of GM-CSF in the asthmatic lung may therefore maintain recently recruited monocytes in an inflammatory and T-cell activating state.     

Magnetic Field Measurement System in Superconducting Combined Function Magnets for the J-PARC Neutrino Beam Line

Magnetic field measurements have been performed for the first full-scale magnet system assembled with the cryostat for the J-PARC proton beam line of neutrino experiment. In the measurement system, the probe position with respect to magnet central axis is measured by a Helium Neon laser and a position sensitive detector, PSD, in order to obtain an exact dipole field strength. Errors associated with the PSD misalignment and influences on the PSD signals by the magnetic field were evaluated. The measured dipole components approached to the design values by compensating those with the probe position. The latest beam simulation indicated that the measured values of magnetic field were good enough for the primary proton beam transport.     

Effects of acute endurance exercise and 8 week training on the production of reactive oxygen species from neutrophils in untrained men

The suboptimal efficacy of the currently available 23-valent pneumococcal vaccine in the growing population of adults >65 years old may be related to the limited immunogenicity of the vaccine polysaccharides in this group. In this study, the majority of elderly outpatients with stable chronic illnesses generated a vigorous IgG response to seven vaccine serotypes comparable to that of healthy young adults at 1, 3, and 16 months after immunization. Moreover, the quality and function of anticapsular antibodies, measured as avidity and in vitro opsonization, were comparable between elderly and young subjects over time. However, a subset (approximately 20%) of elderly outpatients responded to fewer than two of seven serotypes tested 1 and 3 months after immunization, whereas none of the healthy young adults were such poor responders. Thus, despite the adequate mean immune responses of the elderly as a group, a substantial proportion of elderly persons may have poor responses to the currently available pneumococcal vaccine.     

Low threshold current operation of self-assembled InAs/GaAs quantum dot lasers by metal organic chemical vapour deposition

Low threshold current operation of self-assembled InAs/GaAs quantum dot lasers grown by metal organic chemical vapour deposition is reported. Continuous-wave lasing at room temperature with low threshold current (6.7 mA) was achieved at the wavelength of 1.18 /spl mu/m. The threshold current of 6.7 mA is the lowest value so far achieved in quantum dot lasers grown by metal organic chemical vapour deposition. Comparison with photoluminescence spectra indicates that the observed lasing originates from the ground state of InAs quantum dots.     

Low-driving-current temperature-stable 10 Gbit/s operation of p-doped 1.3 /spl mu/m quantum dot lasers between 20 and 90/spl deg/C

Low-driving-current temperature-stable 10 Gbit/s direct modulation was achieved for optimised 200 mum-long short cavity 1.3 mum p-doped quantum dot lasers. Driving conditions were 25.2 mA_p-p for the modulation current and 23.4 mA for the bias current through the whole temperature range from 20 to 90degC     

Determination of rock mass deformation modulus by means of traveling load tests—Part I: Theory of the traveling load test in an open pit

A new scheme named the Traveling Load Test is proposed to measure the macroscopic deformation modulus of the floor rock mass in an open pit, covering a volume of rock mass much larger than conventional loading tests. Facility of the test includes extra-large excavators as load-sources on the flat surface and high-resolution borehole tilt-meters installed in rock to detect the microscopic tilt induced by the load. Emphasis is given to the theory of deformation modulus determination, which is applicable to the field where the floor is fully covered by an accumulation of loose blocks of stone produced by blasting damage and/or stress relief. The relation between the induced tilt and the traveling load is formulated, and subsequently it is shown how the deformation modulus is determined by analyzing the induced tilt-loading distance curve, within acceptable engineering accuracy.