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71.
The discovery of unusual nanorod precipitates in bismuth ferrite doped with Nd and Ti is reported. The atomic structure and chemistry of the nanorods are determined using a combination of high angle annular dark field imaging, electron energy loss spectroscopy, and density functional calculations. It is found that the structure of the BiFeO3 matrix is strongly modified adjacent to the precipitates; the readiness of BiFeO3 to adopt different structural allotropes in turn explains why such a large axial ratio, uncommon in precipitates, is stabilized. In addition, a correlation is found between the alignment of the rods and the orientation of ferroelastic domains in the matrix, which is consistent with the system's attempt to minimize its internal strain. Density functional calculations indicate a finite density of electronic states at the Fermi energy within the rods, suggesting enhanced electrical conductivity along the rod axes, and motivating future investigations of nanorod functionalities.  相似文献   
72.
This work presents a detailed, multiscale, spatially resolved study of the microstructure of an electron beam butt weld of the EN-AW 7020 (Al-Zn-Mg) alloy. Using a combination of optical, scanning and transmission electron microscopy, differential scanning calorimetry, and small-angle X-ray scattering, the distribution of phases in the different areas of the heat-affected zone and of the fusion zone is quantitatively characterized, for two different aging states: naturally aged after welding and artificially aged at 423 K (150 °C). The heat-affected zone consists of regions experiencing different levels of precipitate dissolution and coarsening during welding as well as new precipitation during post-welding heat treatment (PWHT). The microstructure of the fusion zone is typical from a fast solidification process, with a strong solute segregation in the interdendritic zones. The precipitate distribution after PWHT follows this solute distribution, and the resulting hardness is much lower than the relatively homogeneous value in the base metal and the heat-affected zone.  相似文献   
73.
The authors of the first yeast chromosome sequence defined a minimum threshold requirement of 100 codons, above which an open reading frame (ORF) is retained as a putative coding sequence. However, at least 58 yeast genes shorter than 100 codons have an assigned protein function. Therefore, the yeast genome may contain other tiny but functionally important genes that are discarded from analyses by this simple filtering rule. We have established discriminant functions from the in-phase hexamer frequencies of functional genes and of simulated ORFs derived from a stationary Markov chain model. Fifty-two out of the 58 genes were recognized as coding ORFs by our discriminating method. The test was also applied to all the small ORFs (36 to 100 codons) found in the intergenic regions of published chromosomes. It retained 140 new potential tiny coding sequences, among which we identified seven new genes by similarity searches. Our method, used conjointly with similarity searches, can also highlight sequencing errors resulting from the disruption of the coding frame of longer ORFs. This method, by its ability to detect potential coding ORFs, can be a very useful tool for functional analysis.  相似文献   
74.
Mitochondrial dysfunctions are implicated in several pathologies, such as metabolic, cardiovascular, respiratory, and neurological diseases, as well as in cancer and aging. These metabolic alterations are usually assessed in human or murine samples by mitochondrial respiratory chain enzymatic assays, by measuring the oxygen consumption of intact mitochondria isolated from tissues, or from cells obtained after physical or enzymatic disruption of the tissues. However, these methodologies do not maintain tissue multicellular organization and cell-cell interactions, known to influence mitochondrial metabolism. Here, we develop an optimal model to measure mitochondrial oxygen consumption in heart and lung tissue samples using the XF24 Extracellular Flux Analyzer (Seahorse) and discuss the advantages and limitations of this technological approach. Our results demonstrate that tissue organization, as well as mitochondrial ultrastructure and respiratory function, are preserved in heart and lung tissues freshly processed or after overnight conservation at 4 °C. Using this method, we confirmed the repeatedly reported obesity-associated mitochondrial dysfunction in the heart and extended it to the lungs. We set up and validated a new strategy to optimally assess mitochondrial function in murine tissues. As such, this method is of great potential interest for monitoring mitochondrial function in cohort samples.  相似文献   
75.
Platelet factor 4 (PF4) has been recognized as an inhibitor of myeloid progenitors. However, the mechanism of action of this chemokine remains poorly understood. The present study was designed to determine its structure/function relationship. A series of peptides overlapping the C-terminal and central regions of PF4 were analyzed in vitro for their action on murine hematopoietic progenitor growth to assess the minimal sequence length required for activity. The peptides p17-58 and p34-58 possessed an increased hematopoietic inhibitory activity when compared with PF4, whereas the shorter peptides p47-58 and p47-70 were equivalent to the native molecule and the peptide p58-70 was inactive. The PF4 functional motif DLQ located in 54-56 was required for the activity of these peptides. The peptide p34-58 impaired to a similar extent the growth of colony-forming unit-megakaryocyte (CFU-MK) as well as burst-forming unit-erythroid (BFU-E) and colony-forming unit-granulocyte-macrophage (CFU-GM), whereas PF4 was more active on CFU-MK. In the experiments using purified murine CD34(+) marrow cells, statistically significant inhibition induced by p34-58 was shown at concentrations of 2.2 nmol/L or greater for progenitors of the three lineages, whereas that induced by PF4 was seen at 130 nmol/L for CFU-MK and 650 nmol/L for CFU-GM and BFU-E, indicating that the p34-58 acts directly on hematopoietic progenitors and its activity is approximately 60- to 300-fold higher than PF4. The p34-58, unlike PF4, lacked affinity for heparin and its inhibitory activity could not be abrogated by the addition of heparin. In addition, an antibody recognizing p34-58 neutralized the activity of p34-58 but not whole PF4 molecule. These results demonstrate that PF4 contains a functional domain in its central region, which is independent of the heparin binding properties, and provide evidence for a model of heparin-dependent and independent pathways of PF4 in inhibiting hematopoiesis.  相似文献   
76.
Summary There is a well-established literature on the use of concentration measures in informetrics. However, these works have usually been devoted to measures of concentration within a productivity distribution. In a pair of recent papers the author introduced two new measures, both based on the Gini ratio, for measuring the similarity of concentration of productivity between two different informetric distributions. The first of these was derived from Dagum's notion of relative economic affluence; the second - in some ways analogous to the correlation coefficient - is completely new. The purpose of this study is to develop a purely empirical approach to comparative studies of concentration between informetric data sets using both within and between measures thereby greatly extending the original study which considered just two data sets for purposes of illustration of the methods of calculation of the measures.  相似文献   
77.
BACKGROUND: The success rate of combined glaucoma and small incision cataract surgery is not yet established. PATIENTS AND METHODS: Therefore, 56 eyes of 52 patients (mean age 79.0 years) having trabeculectomy combined with phacoemul-sification and implantation of a silicone posterior chamber lens were retrospectively investigated. RESULTS: The mean follow-up was 21.6 weeks. Due to the combined surgery the mean intraocular pressure decreased significantly (p < 0.001) from 21.8 to 14.8 mmHg. Seventy-five percent of the patients did not need any antiglaucomatous medication, while 25% still had to use a local medication, but less frequently. The overall visual acuity increased significantly (p < 0.001) from a preoperative value of 0.24 to 0.52 postoperatively. CONCLUSIONS: The results of combined glaucoma and cataract surgery seem as good as those reported for two separate glaucoma and cataract procedures.  相似文献   
78.
Artificial connective soft tissue, so-called Elastin-Fibrin biomaterial, was investigated to reinforce a pancreato-jejunum anastomosis in the dog. The ambiguous results invite us, however, to improve the quality of the material, especially against proteolytic degradation: elastinolysis and fibrinolysis. Antibiotic was also added. The improved material was tested, first in rabbit then in dog, to repair a large loss of substance in the duodenum, just in front of the Wirsung duct. In view of the successful results, we are now attempting an evaluation in humans, for all indications throughout the digestive system.  相似文献   
79.
Large‐scale flow release experiments are becoming common for improving aquatic habitat quality downstream of dams. Because of the naturally high fine sediment load in the Durance River, France due to inputs from torrential tributaries draining badlands, unpredictable high flow events with dam overspill are not always sufficient to prevent clogging, which can lead to habitat degradation (especially spawning habitats) in bypassed reaches. Therefore, large‐scale flow experiments were conducted on four reaches to test the efficacy of clear‐water releases to improve aquatic habitat conditions. Continuous measurements of water depth, suspended sediment concentrations, and turbidity were conducted during twelve releases and compared on nine. Before and after each release, superficial clogging was measured. The study shows that there is a link between the volume of suspended sediments carried by water releases and the initial clogging. The volumes carried were low compared with the river's annual transport. The effect on clogging can vary significantly from one release to another. In particular, the hydrological context surrounding the releases has a significant influence on clogging. Comparisons of monitoring showed that releases are more effective on reaches that are more severely regulated (high hydrological control) than on those that are less well‐controlled. The areas with the highest initial clogging tend to unclog more than those with lower initial clogging; however, the latter zones are most impacted by ineffective releases. Performing a release on environments with low initial clogging can therefore be environmentally damaging. To ensure that releases are successful and that intervention is warranted, initial clogging should be measured in the field and releases should only be performed if the clogging is judged to be unfavourable.  相似文献   
80.
MapReduce is a design pattern for processing large datasets distributed on a cluster. Its performances are linked to the data structure and the runtime environment. Indeed, data skew can yield an unfair task allocation, but even when the initial allocation produced by the partition function is well balanced, an unfair allocation can occur during the reduce phase due to the heterogeneous performance of nodes. For these reasons, we propose an adaptive multi-agent system. In our approach, the reducer agents interact during the job and the task reallocation is based on negotiation in order to decrease the workload of the most loaded reducer and so the runtime. In this paper, we propose and evaluate two negotiation strategies. Finally, we experiment our multi-agent system with real-world datasets over heterogeneous runtime environment.  相似文献   
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