Multiple functionalization of fluorescent nanoparticles for specific biolabeling and drug delivery of dopamine

The development of fluorescent biolabels for specific targeting and controlled drug release is of paramount importance in biological applications due to their potential in the generation of novel tools for simultaneous diagnosis and treatment of diseases. Dopamine is a neurotransmitter involved in several neurological diseases, such as Parkinson's disease and attention deficit hyperactivity disorder (ADHD), and the controlled delivery of its agonists already proved to have beneficial effects both in vitro and in vivo. Here, we report the synthesis and multiple functionalization of highly fluorescent CdSe/CdS quantum rods for specific biolabeling and controlled drug release. After being transferred into aqueous media, the nanocrystals were made highly biocompatible through PEG conjugation and covered by a carbohydrate shell, which allowed specific GLUT-1 recognition. Controlled attachment of dopamine through an ester bond also allowed hydrolysis by esterases, yielding a smart nanotool for specific biolabeling and controlled drug release.     

Three-way principal component analysis applied to noodles sensory data analysis

The results presented in this paper are issued from the study and the interpretation of a 3-way data matrix constituted from the sensory analysis of wheat noodles. The aim of this work was to provide a complementary understanding of internal relationships between the chemical composition of the noodles and sensory attributes such as color, surface smoothness, elasticity or chewiness. The application of the Tucker3 algorithm involving the noodles composition, the sensory attributes and the assessors as the three modes, facilitates the interpretation of the differences among the types of noodles and also the estimation of the effect of different sources of variability on the sensory evaluation. A joint interpretation of the first and of the second mode (noodles and sensory attributes) allows to link appearance and texture attributes with the composition of the noodles.     

Transition from core-shell to Janus chemical configuration for bimetallic nanoparticles

In order to determine the possibilities to control the chemical configuration of bimetallic nanoparticles, we have considered CuAg nanoparticles synthesized by a physical route as a model in this study. The synthesis was made by pulsed laser deposition under ultra-high vacuum conditions, via a sequential deposition procedure. We show that the temperature of the substrate and the absolute quantity of Ag in a particle are the main parameters that drive the chemical configuration. To explain the transition from a core-shell configuration to a Janus configuration as a function of Ag quantity, we have conducted density-functional theory calculations and atomistic molecular dynamics simulations to investigate the stability of this system. The results are presented together with the experimental observations.     

Single electron tunneling in large scale nanojunction arrays with bisferrocene-nanoparticle hybrids

We report on the fabrication and single electron tunneling behaviour of large scale arrays of nanogap electrodes bridged by bisferrocene-gold nanoparticle hybrids (BFc-AuNP). Coulomb staircase was observed in the low temperature current-voltage curves measured on the junctions with asymmetric tunnel barriers. On the other hand, junctions with symmetric tunneling barrier exhibited mere nonlinear current voltage characteristics without discrete staircase. The experimental results agreed well with simulations based on the orthodox theory. The junction resistance showed thermally activated conduction behaviour at higher temperature. The overall voltage and temperature dependent results show that the transport behaviour of the large arrays of single particle devices obtained by a facile optical lithography and chemical etching process corresponds with the behaviour of single particle devices fabricated by other techniques like e-beam lithography and mechanical breaking methods.     

Summing Pauli asymptotic series to solve the wedge problem

The use of the asymptotic treatment for the wedge diffraction problem established long ago by Pauli [Phys. Rev.54, 924 (1938)] is here revisited and proposed in the character of a powerful computational tool for accurately retrieving the total electromagnetic field even in the near zone. After proving its factorial divergent character, the Pauli series is summed through the Weniger transformation, a nonlinear resummation scheme particularly efficient in the case of factorial divergence. Numerical results are carried out to show the accuracy and effectiveness of the proposed approach.     

Analysis and quantitation of fructooligosaccharides using matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

Inulin is a class of fructooligosaccharide (FOS) derived from plants, which is often used as a natural food ingredient. Inulin is currently used as an additive in baked goods, dairy products, infant formula, and dietary supplements as a result of its purported health-promoting properties. The growth of health-promoting lactobacilli and bifidobacteria is supported by FOS, giving it the classification of a prebiotic; however, its ability to selectivity stimulate only beneficial bacteria has not been demonstrated. In order to better understand the role of inulin and FOS as prebiotics, matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry has been used for qualitative and quantitative analysis on bacterial growth. A method using an internal standard has been developed to quantify the consumption of FOS by Bifidobacterium longum bv. infantis using a calibration curve. Due to the differential consumption of FOS, the calibration curve was modified to include intensity components for each polymer unit in order to achieve more accurate quantitation. The method described was designed to be more rapid, precise, and robust for quantitative analysis when compared to existing methods.     

Spinel LiMn2O4 nanorods as lithium ion battery cathodes

Spinel LiMn2O4 is a low-cost, environmentally friendly, and highly abundant material for Li-ion battery cathodes. Here, we report the hydrothermal synthesis of single-crystalline beta-MnO2 nanorods and their chemical conversion into free-standing single-crystalline LiMn2O4 nanorods using a simple solid-state reaction. The LiMn2O4 nanorods have an average diameter of 130 nm and length of 1.2 microm. Galvanostatic battery testing showed that LiMn2O4 nanorods have a high charge storage capacity at high power rates compared with commercially available powders. More than 85% of the initial charge storage capacity was maintained for over 100 cycles. The structural transformation studies showed that the Li ions intercalated into the cubic phase of the LiMn2O4 with a small change of lattice parameter, followed by the coexistence of two nearly identical cubic phases in the potential range of 3.5 to 4.3 V.     

An integrated approach to the design and management of a supply chain system

In the modern competitive business environment, the design and management of supply chains is one of the most important and critical problems facing managers of multinational companies operating worldwide. There are three levels of decisions in a supply chain: strategic, tactical, and operational levels. The literature generally treats these decisions separately. This study defines a conceptual framework for the development of new modeling approaches for the Production Distribution Logistic System Design (PDSD) problem. In particular, the authors introduce the initial basis for the development of an innovative decision support systems platform capable of integrating the design, management, control, and optimization activities for a supply chain system.