Hardened portland cement pastes of low porosity VI. Mechanism of the hydration process

The hydration of low-porosity portland cement pastes may be divided into three stages. The first stage starts with a fast hydration until 10 to 15% of the cement is hydrated (pre-dormant period), which is followed by a very slow hydration, caused by the formation of a coating on the cement grains (dormant period). After 15 to 20% of the cement is hydrated, the coating is ruptured, and a fast reaction starts, which lasts until about 30% of the cement is hydrated. This is the second stage of the reaction. In the third stage, the hydration slows down, due to retardation by the accumulating hydration products. The mechanism of the third stage is treated quantitatively. The diffusion through the very narrow pores between the hydration products is activated diffusion, and the apparent energy of activation of the diffusion is calculated.     

The quantity and distribution of radiolabeled dexamethasone delivered to tissue by iontophoresis

A pilot study was conducted in the first of two monkeys using either radiolabeled Dm-Na-P or radiolabeled hydrocortisone sodium succinate, together with lidocaine HCl. This study indicated an approximately tenfold increase in the quantity of Dm-Na-P delivered to the test electrodes (4 mA; 20 minutes) whereas the quantity of hydrocortisone delivered from the test electrodes was only marginally (approximately 10%) increased as compared with that from the controls. In terms of an anti-inflammatory activity, the effective dose of Dm-Na-P in all tissue layers underlying the test electrodes was at least tenfold that of the hydrocortisone. Therefore, further trials with hydrocortisone were abandoned. In the second animal, positive test electrodes (5 mA; 20 minutes, were sited over five joints on the right side of the body and matching control electrodes (0 mA; 20 minutes) were placed over corresponding joints on the left side of the body. The control and test electrodes each contained 1.0 ml tritium-labeled Dm-Na-P (approximately 4.0 mg) and 2.0 ml 4% lidocaine HCl (80 mg). Local tissue concentrations of Dm-Na-P were higher than those that would be obtained by systematic therapy and lower than would be obtained by local injection.     

Inhibition of cerebral protein synthesis does not prolong short-term memory.

In 4 experiments, male Swiss-Webster CD-1 mice were given a single sc injection of a cerebral protein synthesis inhibitor, anisomycin (ANI, 1 mg/S), 20 min prior to a single trial of passive avoidance training. Ss demonstrated impaired retention at test given 3 hrs, 6 hrs, 1 day, and 7 days after training. Retention was not significantly different from that of saline controls when tests were given .5 or 1.5 hrs after training. Prolonging inhibition of brain protein synthesis by giving either 1 or 2 additional injections of ANI at 2 hrs or at 2 and 4 hrs after training did not prolong good retention performance. The temporal development of impaired retention in ANI-treated Ss could not be accounted for by drug dosage, duration of protein synthesis inhibition, or nonspecific sickness at test. In contrast to the suggestion that protein synthesis inhibition prolongs short-term memory, these results indicate that short-term memory is not prolonged by antibiotic drugs that inhibit cerebral protein synthesis. All evidence seems consistent with the hypothesis that short-term memory is independent of protein synthesis and that the establishment of long-term memory depends on protein synthesis during or shortly after training. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Identifiability as a deterrant to social loafing: Two cheering experiments.

Two experiments with 156 male undergraduates tested the extent to which the identifiability of one's individual output moderates social loafing—the reduction of individual efforts due to the social presence of others. In the 1st stage of Exp I, Ss were asked to produce noise either alone, in groups of 2 and 6, or in pseudogroups where Ss actually shouted alone but believed that 1 or 5 other people were shouting with them. As in previous research, Ss exerted less effort when they thought that they were shouting in groups than when they shouted alone. In the 2nd stage, the same Ss were led to believe that their outputs would be identifiable even when they cheered in groups. This manipulation eliminated social loafing. Exp II demonstrated that when individual outputs were always identifiable (even in groups), Ss consistently exerted high levels of effort, and if their outputs were never identifiable (even when alone), they consistently exerted low levels of effort across all group sizes. Results suggest that identifiability is an important mediator of social loafing. (15 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Survey of shell egg processing plant sanitation programs: effects on non-egg-contact surfaces

To successfully implement a hazard analysis critical control point plan, prerequisite programs are essential. Sanitation standard operating procedures are an important part of such a plan and can reduce contamination levels so that food safety and quality are not adversely affected. Noncontact surfaces in the shell egg processing plants can serve as a reservoir of cross-contamination. The objective of this study was to assess the efficacy of sanitation programs used in a variety of shell egg processing facilities (in-line, off-line, and mixed operations). Fourteen different noncontact surfaces were sampled in nine commercial facilities across the southeastern United States. Non-egg-contact surfaces were defined as those where the shell egg does not come into direct contact with the surface or with the fluid from that surface. Gauze pads soaked in sterile phosphate-buffered saline were used for sampling at the end of a processing day (POST) and again the next morning prior to operations (PRE). Aerobic plate counts (APCs) and numbers of Enterobacteriaceae were determined. No significant differences (P > 0.05) were found between POST and PRE counts for either population recovered from the 14 sampling sites. Only samples from the floor under the farm belts, nest-run loader, washers, and packer heads were reduced by 1 log CFU/ml of rinsate for APCs or Enterobacteriaceae counts. APCs of more than 10(4) CFU/ml of rinsate were recovered from many samples. Highest APCs were found on the floor under the farm belt and on shelves of the nest-run carts. High APCs were found on the wheel surface for off-line carts and on the loading dock floor. Highest Enterobacteriaceae counts were found in samples from the floor, drain, and nest-run egg cart shelves. A lack of significant difference between POST and PRE counts indicates that current sanitation programs could be improved. These data suggest that traffic patterns for the movement of eggs and materials through the plant should be reevaluated so that cross-contamination is reduced.     

Intra-pituitary regulation of gonadotrophs in male rodents and primates

Paracrine and autocrine regulation is well established in many organs including the gonads, but the notion of communication among pituitary cells is a relatively new concept. The FSH-beta and GnRH-receptor genes are up-regulated by pituitary activin and down-regulated by pituitary follistatin, and circulating inhibin disrupts this local regulation by functioning as an endogenous competitor of the activin receptor. Activin and follistatin production by folliculostellate cells may play a central role in these responses. alpha-Subunit expression is maintained at high levels in the absence of GnRH through unknown mechanisms. There is evidence that the intra-pituitary regulation of FSH-beta and GnRH-receptor gene expression may activate pubertal maturation in male rats. Finally, there are marked differences in follistatin expression and its regulation by GnRH and androgens in male primates and rats that appear to explain species differences in the differential secretion of FSH and LH, although the physiological significance of these differences is not yet known.     

Overdetermined least-squares aberration estimates using common-midpoint signals

As medical ultrasound imaging moves to larger apertures and higher frequencies, tissue sound-speed variations continue to limit resolution. In geophysical imaging, a standard approach for estimating near-surface aberrating delays is to analyze the time shifts between common-midpoint signals. This requires complete data-echoes from every source/receiver pair in the array. Unfocused common-midpoint signals remain highly correlated in the presence of delay aberrations; there is also tremendous redundancy in the data. In medical ultrasound, this technique has been impaired by the wide-angle, random-scattering nature of tissue. This has made it difficult to estimate azimuth-dependent aberration profiles or to harness the full redundancy in the complete data. Prefiltering the data with two-dimensional fan filters mitigates these problems, permitting highly overdetermined, least-squares solutions for the aberration profiles at many steering angles. In experiments with a tissue-mimicking phantom target and silicone rubber aberrators at nonzero stand-off distances from a one-dimensional phased array, this overdetermined, fan-filtering algorithm significantly outperformed other phase-screen algorithms based on nearest-neighbor cross-correlation, speckle brightness maximization, and common-midpoint signal analysis. Our results imply that there is still progress to be made in imaging with single-valued focusing operators. It also appears that the signal-to-noise penalty for using complete data sets is partially compensated by the overdetermined nature of the problem.