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71.
Muhammad Zaman Usman Khalid Maria Abdul Ghafoor Raja Waqar Siddique Kishwar Sultana Muhammad Wahab Amjad 《Polymer-Plastics Technology and Engineering》2017,56(16):1713-1722
Transdermal patches loaded with ramipril and repaglinide were prepared with the ambition to develop matrix-type transdermal drug delivery system for enhanced permeability and hence improved bioavailability. Different formulations were designed by intermittent concentrations of hydroxypropyl methylcellulose K4M as hydrophilic polymer and ethyl cellulose as hydrophobic polymer. Solvent casting method was used for the fabrication of transdermal patches. Oleic acid and propylene glycol were used to enhance permeability along with polyethylene glycol 400 as plasticizer. Newly designed patches were then evaluated for various physicochemical and mechanical properties. Compatibility studies were performed by Fourier transformed infrared spectroscopy which did not reveal any interaction between drug and polymers. Crystalline nature of drugs was confirmed when they were subjected to X-ray diffraction study and surface morphological studies using scanning electron microscopy. Transdermal patches were of good mechanical strength with folding endurance of more than 300-fold and 100% flatness. Percent drug contents of ramipril and repaglinide ranged from 90 to 105%, i.e., analogous to official limits. In vitro and ex vivo permeation studies were executed using franz diffusion cell. The cumulative amount of drug permeated through skin was 55.22–112.72% for repaglinide and 73.14–91.46% for ramipril. The release behavior of the permeated drug was analyzed by the application of model-dependent approaches. The results showed that Korsmeyer–Peppas model was found to be dominating in most of the formulations and drugs followed diffusion mechanism. It could be concluded that hydroxypropyl methylcellulose K4M and ethyl cellulose has great potential for ramipril and repaglinide as a vector for transdermal drug delivery effectively because of the formation of smooth surfaces of patches, high folding endurance, and entrapment efficiency with the ability to release the drugs in sustained manner. 相似文献
72.
The world will need greatly increased energy supply in the future for sustained economic growth, but the related CO2 emissions and the resulting climate changes are becoming major concerns. CO2 is one of the most important greenhouse gases that is said to be responsible for approximately 60% of the global warming. Along with improvement of energy efficiency and increased use of renewable energy sources, carbon capture and sequestration (CCS) is expected to play a major role in curbing the greenhouse gas emissions on a global scale. This article reviews the various options and technologies for CO2 capture, specifically for stationary power generation sources. Many options exist for carbon dioxide capture from such sources, which vary with power plant types, and include post-combustion capture, pre-combustion capture, oxy fuel combustion capture, and chemical looping combustion capture. Various carbon dioxide separation technologies can be utilized with these options, such as chemical absorption, physical absorption, adsorption, and membrane separation. Most of these capture technologies are still at early stages of development. Recent progress and remaining challenges for the various CO2 capture options and technologies are reviewed in terms of capacity, selectivity, stability, energy requirements, etc. Hybrid and modified systems hold huge future potentials, but significant progress is required in materials synthesis and stability, and implementations of these systems on demonstration plants are needed. Improvements and progress made through applications of process systems engineering concepts and tools are highlighted and current gaps in the knowledge are also mentioned. Finally, some recommendations are made for future research directions. 相似文献
73.
A finite element model has been developed to simulate two-phase, (i.e., oil and gas) flow and solid deformation in a dual-porosity medium. The model accounts for coupling between solid deformations and fluid flow in both the primary medium (representing the matrix pores and solid) and the secondary medium (used to represent fractures in the present study). The model is verified against relevant analytical solutions and then applied to the problem of an inclined wellbore under generalized plane strain conditions, subjected to a three-dimensional in situ state of stress in a fractured formation saturated with oil and gas. A parametric study has been carried out to demonstrate the effect of dual-porosity parameters, phase saturations, and interaction between the two media. The implementation of double effective stress laws in the present study is a significant deviation from some classical dual-porosity models and helps to incorporate the effect of deformation of the secondary medium (representing the fractures). 相似文献
74.
75.
Hyunseock Jie PhD Vladimir Luzin Mukter Zaman Anvar Valiyaparambil Abdulsalam Keun Hwa Chae PhD Hyung-il Choi Vladimir Levchenko Arend Nijhuis Jung H. Kim Mislav Mustapić Shi Xue Dou Yusuke Yamauchi Aslam Khan Md. Shahriar A. Hossain 《Journal of the American Ceramic Society》2020,103(10):5488-5495
In this study, we analyze the properties of boron isotope (11B)-rich powders from three different sources, that is, American, Cambridge, and Pavezyum, to fabricate the bulk Mg11B2 superconductors and evaluate their superconducting properties. While 11B-rich powder is an essential precursor to fabricate Mg11B2 superconductors for fusion magnet applications, the properties of the 11B powder turned out to be critical to determine the quality of the final superconducting product. Therefore, appropriate control of processing conditions is needed to comply with the requirements of the nuclear fusion application. Analysis of the B isotope ratio by accelerator mass spectroscopy and neutron transmission revealed that all three types of powder are enriched with 11B to better than 99 at % quality. In addition, Pavezyum's 11B shows the lowest crystallinity and smallest crystalline domain size as evidenced by the high-resolution X-ray diffractometer and scanning electron microscopy. The chemical states of the boron isotope investigated with near edge X-ray absorption fine structure spectroscopy and X-ray photoemission spectroscopy also reveals that Pavezyum boron has amorphous structure. Mg11B2 bulks and multi-filamentary (12-filament) wires have been manufactured, sintered at different temperatures and characterized via the transport critical current density. The wire with Pavezyum 11B shows three times higher current carrying capacity at a particular magnetic field compared to the wire using Cambridge 11B and hence, Pavezyum 11B boron has the potential for manufacturing fusion grade Mg11B2 based magnets. The results of this study demonstrated that Boron powders with higher purity, smaller grain size and lower crystallinity are critical for improving the superconducting and electronic properties of Mg11B2 samples fabricated from the powder. Thus, the low-neutron-activation Mg11B2 is possibly an affordable and technically viable candidate to replace NbTi superconductors in the low field poloidal field and correction coils for the next-generation fusion reactors. 相似文献
76.
Atif Kamil Mubarak Ali Khan Muhammad AAsim Nadir Zaman Khan Raham Sher Khan Muhsin Jamal Waqar Ahmad Mir Azam Khan Fazal Jalil 《Biocell》2019,43(3):167-174
Several toxic compounds are known to induce apoptosis in mammalian cell lines. The human neuroblastoma
cells (SH-SY5Y) were exposed to the phosphatase inhibiting toxin okadaic acid (OA) or hydrogen peroxide (H2O2)
to induce apoptosis as well as generate reactive oxygen species (ROS). Mitoxantrone (MXT) was used as a positive
control for apoptosis. The SH-SY5Y cells were transfected with eukaryotic expression plasmid pHyPer-dMito encoding
mitochondrial-targeted fluorescent or pHyPer-dCito encoding cytoplasmic-targeted fluorescent sensor for hydrogen
peroxide (HyPer). The ERp57, also called GRP58 (Glucose-regulated protein 58), is a stress protein induced in
conditions like glucose starvation and viral infection. Recently ERp57 was shown to translocate from the endoplasmatic
reticulum to the cell surface in anthracycline-induced apoptotic cells. ERp57 co-translocation together with calreticulin
has been suggested to be crucial for recognizing tumor cells to induce immunogenic cell death. ERp57 translocation
after exposure to okadaic acid was studied using immunofluorescence and confocal microscopy. These studies indicated
that okadaic acid has induced the translocation of ERp57 to the cellular membrane. 相似文献
77.
Babar Zaman Muhammad Hisyam Lee Muhammad Riaz Mu'azu Ramat Abujiya 《Quality and Reliability Engineering International》2019,35(6):1542-1581
Random causes are vital part of every process in manufacturing and nonmanufacturing environments, and these do not affect the product features. Special causes, on the other hand, come because of some burden(s) in a process and requires special attention; otherwise, it ruins the products excellence. Special causes are categorized into small, moderate, and large shifts and are handled by statistical quality control charts. The Shewhart control chart is well known for large shifts, while the cumulative sum and exponentially weighted moving average are more effective in detecting small to moderate shifts. However, in practice, many processes require the simultaneous monitoring of both the small to the large shifts. In this study, we have designed an adaptive EWMA for dispersion parameter in connection with Huber and Tukey's bisquare functions. The performance measures used in this study include average run length, extra quadratic loss, relative average run length, and performance‐comparison index. We have observed that the study proposals are good competitors to the other counter parts for an efficient monitoring of shifts of varying amounts. An illustrative example using real data is given to demonstrate the implementation of the study proposal. 相似文献
78.
Javed Ali S. Islam Sirajul Islam Gul Zaman 《Computers & Mathematics with Applications》2010,59(6):2000-2006
In this work, we solve multipoint boundary value problems using the Optimal Homotopy Asymptotic Method (OHAM).The proposed method is tested upon several problems from the literature and the results are compared with the available exact solution. This method provides easy tools to control the convergence region of approximating solution series where ever necessary. 相似文献
79.
80.
Temperature‐Insensitive High Strain in Lead‐Free Bi0.5(Na0.84K0.16)0.5TiO3–0.04SrTiO3 Ceramics for Actuator Applications 下载免费PDF全文
Rizwan Ahmed Malik Ali Hussain Adnan Maqbool Arif Zaman Chang‐Won Ahn Jamil Ur Rahman Tae‐Kwon Song Won‐Jeong Kim Myong‐Ho Kim 《Journal of the American Ceramic Society》2015,98(12):3842-3848
Lead‐free piezoelectric ceramics, 0.96[{Bi0.5 (Na0.84K0.16)0.5}1?xLix(Ti1?yNby)O3]–0.04SrTiO3 (BNKLiTN–ST) with x, y = 0–0.030, were synthesized by solid‐state reaction method. X‐ray diffraction patterns indicated that Li and Nb successfully diffused into the BNKT–ST lattice and formed a pure perovskite structure with x, y ≤ 0.025. Increasing the Li and Nb contents (x, y = 0.020) induced a phase transformation from the coexistent rhombohedral–tetragonal phases for pure BNKT–ST ceramics to a pseudocubic phase, resulting in degradation of the remnant polarization and coercive field. However, the field‐induced strain was markedly enhanced at x, y = 0.020, giving rise to a giant dynamic piezoelectric constant (d33* = Smax/Emax = 800 pm/V). Furthermore, the temperature dependence of the field‐induced strain response showed temperature‐insensitivity up to 120°C. To explore its potential for device applications, a 10‐layered stack‐type multilayer actuator was fabricated from the optimal composition (x, y = 0.020). This actuator showed a large Smax/Emax of 600 pm/V at a relatively low driving field of 4.5 kV/mm suggesting highly promising results in lead‐free BNT‐based ceramics. 相似文献