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91.
Deng J Li L Stephens D Tian Y Robinson D 《Drug development and industrial pharmacy》2004,30(4):341-346
A polyanhydride implant containing gentamicin sulfate was fabricated using a laboratory-scale injection-molding machine. After injection molding, the implants were subject to heat treatment at 60°C for various time periods with or without nitrogen protection. The impact of this heat treatment on the in vitro properties of the implants including copolymer molecular weights, mechanical properties, and in vitro drug-release profiles was investigated. This heat treatment caused a drastic drop in the molecular weight of the copolymer. Heating without nitrogen protection resulted in the hardening of the implant, but heating in the presence of nitrogen rendered the implant less rigid. It was also found that a faster in vitro drug release profile was shown by implants heated without nitrogen protection and a pronounced slowing down in drug release was exhibited by implants heated with nitrogen protection. 相似文献
92.
Kai Feng Ning Gao Wanlin Zhang Kang Zhou Hao Dong Peng Wang Li Tian Guokang He Guangtao Li 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(9)
Droplet‐based microfluidics enable the production of emulsions and microparticles with spherical shapes, but the high‐throughput fabrication of nonspherical emulsions and microparticles still remains challenging because interfacial tension plays a dominant role during preparation. Herein, ionic liquids (ILs) containing salts, which possess sufficient osmotic pressure to realize water transport and phase separation, are introduced as inner cores of oil‐in‐oil‐in‐water double emulsions and it is shown that nonspherical emulsions can be constructed by osmosis‐driven arrested coalescence of inner cores. Subsequently, ultraviolet polymerization of the nonspherical emulsions leads to nonspherical microparticles. By tailoring the number, composition, and size of inner cores as well as coalescence time, a variety of nonspherical shapes such as dumbbell, rod, spindle, snowman, tumbler, three‐pointed star, triangle, and scalene triangle are created. Importantly, benefitting from excellent solvency of ILs, this system can serve as a general platform to produce nonspherical microparticles made from different materials. Moreover, by controlling the osmotic pressure, programmed coalescence of inner cores in double emulsions is realizable, which indicates the potential to build microreactors. Thus, a simple and high‐throughput strategy to create nonspherical microparticles with arrested coalescence shapes is developed for the first time and can be further used to construct novel materials and microreactors. 相似文献
93.
The aerodynamic and aeroacoustic performances of outdoor unit with two different types of grille have been investigated in present study. Experimental results indicate that the grille sharp will affect the flow rate and increase broadband noise level of outdoor unit. Based on noise generation mechanism and CFD simulation, vortex shedding noise model and inlet turbulence noise model are adopted to predict the broadband noise level of outdoor unit. When vortex shedding noise is concerned, the wake parameters should be calculated at 3 mm downstream of grille to achieve good accuracy. Inlet turbulence noise is generated from the interaction between blade wake and the grille, and plays less important role in present outdoor unit configuration. In comparison with experimental results, it is shown that the broadband noise prediction method could provide reasonable accuracy and the error between prediction and experiment is less than 1 dBA. 相似文献
94.
95.
安全阀是保障石油化工设备正常运行的重要绀成部分,本文以目前广泛采用的AP1581标准为基础,建市安全阀的失效分析系统.该系统在计算机理和界向交互方式上改进原标准,可以根据工厂设备和安全阀管理数据,分析安伞阀的开启失效和泄漏频率,为提高石油化工牛产的安全性和可靠性提供重要的分析依据. 相似文献
96.
未来课堂是针对未来创新人才培养需求、以新课程改革为支撑,以互动为核心,以促进课堂主体和谐、自由发展的一种高效课堂。本文分析了未来课堂的必要性和特性的基础上,构建了基于云端的未来课堂理论模型,该模型对创新教育有一定的借鉴作用。 相似文献
97.
碾压混凝土VC值的讨论与分析 总被引:1,自引:0,他引:1
大量工程实践证明,VC值对碾压混凝土的性能有着重要影响。随着碾压混凝土筑坝技术的发展,VC值的取值逐渐由大变小,碾压混凝土拌和物也从干硬性混凝土逐渐过渡到半塑性混凝土,改变了传统的“金包银”施工方式和防渗结构。通过对碾压混凝土VC值的讨论与分析研究,可为碾压混凝土筑坝技术的发展提供理论依据。 相似文献
98.
The mechanical properties of hot rolled strip are the key index of product quality,and the soft sensing of them is an important decision basis for the control a... 相似文献
99.
When the ice-going ships advance in the polar region,the navigation in the floe ice region is often encountered,the hull will suffer the high-frequency contact ... 相似文献
100.
Chronic kidney disease (CKD), as one of the main complications of many autoimmune diseases, is difficult to cure, which places a huge burden on patients’ health and the economy and poses a great threat to human health. At present, the mainstream view is that autoimmune diseases are a series of diseases and complications caused by immune cell dysfunction leading to the attack of an organism’s tissues by its immune cells. The kidney is the organ most seriously affected by autoimmune diseases as it has a very close relationship with immune cells. With the development of an in-depth understanding of cell metabolism in recent years, an increasing number of scientists have discovered the metabolic changes in immune cells in the process of disease development, and we have a clearer understanding of the characteristics of the metabolic changes in immune cells. This suggests that the regulation of immune cell metabolism provides a new direction for the treatment and prevention of kidney damage caused by autoimmune diseases. Macrophages are important immune cells and are a double-edged sword in the repair process of kidney injury. Although they can repair damaged kidney tissue, over-repair will also lead to the loss of renal structural reconstruction function. In this review, from the perspective of metabolism, the metabolic characteristics of macrophages in the process of renal injury induced by autoimmune diseases are described, and the metabolites that can regulate the function of macrophages are summarized. We believe that treating macrophage metabolism as a target can provide new ideas for the treatment of the renal injury caused by autoimmune diseases. 相似文献