基于进程管理的气象文件监控处理

文件实时监控处理过程在控制程序处理过程中被广泛运用。本文结合文件处理的实际工作,描述了文件处理程序的监控处理过程,实现了基于进程管理的文件监控处理与预处理过程的协同工作。     

Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry for Quantification of Glycyrrhetic Acid in Human Plasma

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) for the determination of glycyrrhetic acid in human plasma with ginsenoside Rh2 as internal standard was developed and validated. The plasma samples were prepared via liquid-liquid extraction with ethyl acetate. Chromatographic separation was accomplished on a Venusil MP-C18(50 mm×2.1 mm, 5μm i.d.) column at 25℃. The mobile phase consisted of acetonitrile/5 mmol·L-1 ammonium acetate(10:90, volume ratio) at a flow rate of 0.4 mL/min. Negative electrospray ionization was utilized as the ionization source. Glycyrrhetic acid and internal standard were determined via the mutiple reaction monitoring of precursor→production ion transitions at m/z 469→425, 409 and m/z 621→161,respectively. Each sample was chromatographed within 2.5 min. The lower limit of uantification was 0.50 ng/mL for 200 μL of plasma sample and the linear range was from 0.50 ng/mL to 800 ng/mL. The intra-and inter-day precisions were less than 8.76% in terms of relative standard deviation(RSD), and the accuracy was within a range of -3.25%-1.32% in terms of relative error(RE). The method was successfully applied to the pharmacokinetic studies of glycyrrhetic acid in healthy male Chinese volunteers after a single oral administration of 75 mg of glycyrrhizin.     

基于curvelet变换的光学器件表面特征识别

为了精确识别复杂精密光学器件在制造过程中由于工艺要求不可避免产生的缺陷特征,基于曲线波(Curvelet)变换优良的曲线特征识别和强大的稀疏表示能力,提出了一种基于曲线波变换的缺陷特征识别方法,该方法采用变换域特征分离,在空间域获得特征识别后的器件表面图像.仿真结果和实验结果证明,提出的方法比传统小波算法精度和准确度更...     

A fluorescent porous silicon-based biosensor for small molecule detection

Fluorescent porous silicon was prepared as a stable biosensor chip substrate. The aminopropyltriethoxysilane (APTES) molecules are attached in the pores of the porous silicon with a crosslink method, and when the molecules are added into the chip, the fluorescence intensity is reduced according to the concentration of the APTES. Controlled experiments are also presented with the small molecule that cannot be covalently coupled, and the results show that this kind of sensor chip has better specificity. Compared with other conventional methods, this method is simple, quick and label-free.     

Game Theory Based False Negative Probability of Embedded Watermark Under Unintentional and Steganalysis Attacks

Steganalysis attack is to statistically estimate the embedded watermark in the watermarked multimedia,and the estimated watermark may be destroyed by the attacker.The existing methods of false negative probability,however,do not consider the influence of steganalysis attack.This paper proposed the game theory based false negative probability to estimate the impacts of steganalysis attack,as well as unintentional attack.Specifically,game theory was used to model the collision between the embedment and steganalysis attack,and derive the optimal building embedding/attacking strategy.Such optimal playing strategies devote to calculating the attacker destructed watermark,used for calculation of the game theory based false negative probability.The experimental results show that watermark detection reliability measured using our proposed method,in comparison,can better reflect the real scenario in which the embedded watermark undergoes unintentional attack and the attacker using steganalysis attack.This paper provides a foundation for investigating countermeasures of digital watermarking community against steganalysis attack.     

基于高通量测序分析毛菊苣醇提物对db/db小鼠肠道菌群的影响

该文探究毛菊苣醇提物对糖尿病小鼠（db/db小鼠）肠道菌群的影响。该研究以m/m小鼠为正常对照组（CON组）,db/db小鼠随机分为模型组（MOD组）、二甲双胍组（MET组）、毛菊苣醇提物低剂量组（CGL组）、毛菊苣醇提物高剂量组（CGH组）。灌胃给药8周,对小鼠体质量、空腹血糖、肝脏总胆固醇（TC）、甘油三酯（TG）进行分析,对小鼠粪便进行16S rRNA测序分析,探究毛菊苣醇提物对小鼠肠道菌群的影响。毛菊苣醇提物高剂量组可调节db/db小鼠体质量及血糖,显著降低db/db小鼠TC、TG水平（P<0.05）;测序结果显示CON组、MOD组、CGH组三组小鼠肠道菌群情况存在差异,毛菊苣醇提物给药可改善db/db 小鼠的肠道菌群失调,上调db/db小鼠肠道菌群中有益菌双歧杆菌属（Bifidobacterium）、Romboutsia、普雷沃氏菌属（Prevotella）菌群相对丰度。研究证明了毛菊苣醇提物给药能调节db/db小鼠肠道菌群,通过提高有益菌相对丰度调节糖脂代谢,可为新疆地产毛菊苣药材资源的开发利用提供全新的研究思路。     

On the measurement of electrons in the 5–20 MeV range in liquids

Recent approaches to solve the solar neutrino problem comprise both new theoretical ideas and newly developed techniques for huge underground detectors. The investigation of electrons produced by neutrinos from the ⁸B decay is particularly interesting. Earlier bubble chamber photographs of electron tracks (5–20 MeV) in two liquids, the measurements of their energy and direction, may help to optimize the design of these detectors.     

酒花黄酮提取工艺和含量测定

建立酒花黄酮的提取方法和含量测定方法。采用NaNO2-Al(NO3)3-NaOH显色法,以芦丁为对照品,通过单因素试验和L9(34)正交设计确定酒花黄酮的提取方法,并测定和比较酒花、酒糟和啤酒中黄酮的含量。结果表明：酒花黄酮提取方法为样品加入50倍的甲醇,超声提取2次,每次1h,酒花黄酮含量为69.98mg/g,酒糟和啤酒中黄酮的含量较低。对照品芦丁在10.2～40.8μg/mL质量浓度范围内与吸光度呈良好线性关系,平均回收率99.33%,RSD=3.60%。该提取方法合理,含量测定方法简便、快速、准确,可用于酒花黄酮提取物制备及其质量控制。