复方中草药牙粉治疗慢性龈缘炎的疗效

目的观察复方中草药牙粉治疗慢性龈缘炎的临床疗效。方法选择慢性龈缘炎患者40例,按随机数字表法分为2组：试验组（n=20）给予复方中草药牙粉配制的漱口水含漱,对照组（n=20）给予生理盐水含漱,2组受试者使用含漱液前和使用10d后分别测定牙龈指数、菌斑指数和口臭指数。结果用药前2组各观察指标比较,差异均无统计学意义（均P〉0.05）;试验组用药后各指标较用药前均有明显降低（均P〈0.01）;对照组用药前后各项指标组间比较差异均无统计学意义（均P〉0.05）;用药后试验组与对照组各指标比较差异均有统计学意义（P〈0.05或P〈0.01）。结论复方中草药牙粉可以抑制牙菌斑的形成,可减轻牙龈的症状。     

一种解酒护肝片对小鼠酒精性肝损伤的保护作用的研究

目的:研究解酒护肝片对小鼠急性酒精性肝损伤的保护作用。方法:将小鼠随机分为5组,正常组、模型组、解酒护肝片低剂量组、中剂量组、高剂量组。采用白酒灌胃造模,造模与给药同时进行。6周后测定血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、丙二醛(MDA)、甘油三酯(TG)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)水平。结果:各剂量解酒护肝片能显著降低小鼠血清ALT、AST活性和肝组织MDA、TG含量(P<0.05或P<0.01),提高肝组织SOD和GSH活性,各预防治疗组之间比较提示,以高剂量解酒护肝片作用最为显著。结论:解酒护肝片能有效预防小鼠酒精性肝病。     

吡啶类化合物的合成及应用研究进展

综合论述了吡啶类化合物的合成及应用研究进展,对其中较重要的几类化合物进行了讨论,并介绍了该类化合物在医药方面的应用情况。     

分子蒸馏技术在医药行业的应用及研究进展

介绍了分子蒸馏基本原理与技术特点,是一种新型的液一液分离纯化技术。具有蒸馏温度低、受热时间短、分离程度高等优点。叙述了分子蒸馏在维生素、不饱和脂肪酸、挥发油等中药及合成药物粗产物有效成分的分离纯化方面的应用及进展。认为我国在这方面的研究应用起步相对晚。需要进一步探索分离与纯化的最佳工艺条件。     

Development of an early estimation method for predicting later osteogenic differentiation activity of rat mesenchymal stromal cells from their attachment areas

Cell morphology has received considerable attention in recent years owing to its possible relationship with cell functions, including proliferation, differentiation, and migration. Recent evidence suggests that extracellular environments can also mediate cell functions, particularly cell adhesion. The aims of this study were to investigate the correlation between osteogenic differentiation activity and the morphology of rat mesenchymal stromal cells (MSCs), and to develop a method of estimating osteogenic differentiation capability of MSCs on biomaterials. We measured the attachment areas of MSCs on substrates with various types of surface after 2 h of seeding, and quantified the amount of osteocalcin secreted from MSCs after 3 weeks of culture under osteogenic differentiation conditions. MSCs with small attachment areas showed a high osteogenic differentiation activity. These findings indicate that cell attachment areas correlate well with the osteogenic differentiation activity of MSCs. They also suggest that the measurement of cell attachment areas is useful for estimating the osteogenic differentiation activity of MSCs and is a practical tool for applications of MSCs in regenerative medicine.     

High-speed tracking of murine cardiac stem cells by harmonic nanodoublers

Potassium niobate nonlinear nanoparticles are used for the first time to monitor the evolution of embryonic stem cells (ESC) by second harmonic microscopy. These particles feature the complete absence of photo-bleaching and unlimited excitation wavelength flexibility. The potential of this approach is made evident for tissue-regeneration studies and applications, by capturing a high-speed movie of ESC-derived cardiomyocytes autonomously beating within a cluster. Time-resolved data are analyzed to retrieve 3D information of the contraction pattern at the cellular level.     

OPC技术在现代中药提取控制系统中的应用

简要介绍了OPC技术和现代中药提取控制技术.根据实际需求,使用VB+SQL Server和OPC技术开发现代中药提取控制系统客户端程序,采集数据形成历史数据库,获得了良好的效果,弥补了原有系统的不足.实践证明使用OPC技术开发客户端程序,不必考虑驱动程序和接口问题,简单易行.     

SIMULTANEOUS QUANTIFICATION OF THREE MAJOR ACTIVE COMPONENTS IN GRANULES OF THE TRADITIONAL CHINESE MEDICINE “SHU-JIN-TONG-LUO” BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

A simple, sensitive, and reliable high-performance liquid chromatography (HPLC) method has been developed for the simultaneous quantification of three major bioactive components (hydroxysafflor yellow A, geniposide, and paeoniflorin) in “Shu-Jin-Tong-Luo” granules (SJTLG), for quality control of this commonly prescribed traditional Chinese medicine. Chromatographic separation was carried out on a Hypersil-ODS column (250 mm × 4.6 mm ID, 5.0 μm) and isocratic elution was employed using acetonitrile and 50 mM potassium dihydrogen phosphate buffer as the mobile phase. The method was fully validated with respect to linearity, precision, accuracy, specificity, and robustness. The validated method was applied successfully to the quantification of the investigated components in samples of SJTLG from different production batches for quality evaluation and control. The results indicate that the HPLC method described is a simple and accurate quality control method for analysis of SJTLG.     

Martin T. Orne (1927–2000)).

Memorializes Martin T. Orne, one of the world's foremost authorities on hypnosis, an expert on the social psychology of the psychological experiment, and a leading figure in behavioral medicine. During his career he held appointments at the University of Pennsylvania in psychiatry and psychology. His primary research interest was the objective study of subjective states of mind. His doctoral dissertation, published in 1959, largely defined the field of hypnosis research for more than 20 yrs, and his studies of analgesia, antisocial behavior, and human performance are regarded as classic contributions to the field. Largely on the basis of his experience with hypnosis, Orne developed an analysis of the psychological experiment as a distinctive social situation in which both Ss and experimenters are active participants. In addition, he served as Editor in Chief of the International Journal of Clinical and Experimental Hypnosis from 1961–1992. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

微柱高效液相色谱技术在中草药质量监控中的应用进展

介绍了微柱高效液相色谱(MHPLC)技术在中草药质量监控中的应用现状,简要论述了微柱高效液相色谱技术及其联用技术。