第二套常减压装置低温热回收技术的应用

常减压装置低温余热较多.利用较少,造成热量损失。利用初顶油气、稳定石脑油等低温余热加热除盐水建立热水站,在节汽、节电等方面取得了较好的效果。     

大气激光通信中的光斑特性模拟和验证

根据空-地大气激光通信信道的特性,基于惠更斯-菲涅耳原理,应用夫琅禾费圆孔衍射的算法,对光波强度和光斑图像在光束截面内的分布进行分析及计算,研究了传输距离、发射孔径、激光波长以及湍流结构常数等对光斑形状及光强分布的影响。利用对数正态分布建立了大气湍流信道模型,通过对不同传输距离条件下光斑上不同点的光强分布进行计算统计和仿真分析,实验和仿真结果表明：光斑的光强分布图样服从贝塞尔分布。因此,在相同的大气湍流条件下,选择较长波长激光和较大孔径的发射器,可以有效降低光强闪烁引起的衰减,从而提高大气激光的通信质量。     

基于多通路融合网络的高速公路雾天能见度等级识别

雾天是影响高速公路交通安全的重要因素。研究从监控图像进行高速公路雾天能见度的自动识别方法可以为交通管理部门的智能管理和决策提供技术支持。根据大气散射模型分析出与雾浓度相关的多个物理因素,提出了综合这些物理因素的多通路融合识别网络。该网络使用三个通路联合学习深度视觉特征、传输矩阵特征和场景深度特征,并设计注意力融合模块来自适应地融合这三类特征以进行能见度等级识别。同时构建了一个合成数据集和一个真实的高速公路场景数据集,用于网络参数学习和性能评估。实景数据集中的图像是从中国多条高速公路的监控视频中收集的。在这两个数据集上的实验表明,所提方法可以适应不同的监控拍摄场景,能够比现有方法更准确地识别能见度等级,有效提升了识别精度。     

基于互补原理确定黄土高原Budyko方程的流域特性参数

Budyko方程的流域特性参数一般根据植被覆盖度等下垫面特征进行确定,但相关资料不易获取。本文针对黄土高原地区29个小流域,通过分析流域特性参数、植被覆盖度和互补关系中大气湿润指数之间的关系发现,大气湿润指数能够间接反映植被覆盖度的大小,进而能够利用常规气象数据确定流域特性参数,并拟合出了经验公式。相比采用固定流域特性参数,这种方法能够提高Budyko方程对实际蒸散发量的模拟效果。相比于植被覆盖度等下垫面资料,常规气象数据时间序列长、且更易获取,因此本方法具有较好的应用前景。     

基于混合电场线性叠加原理的换流变压器内部电场分布规律研究

换流变压器是特高压直流输电系统中的关键设备,其阀侧承受着交直流复合电压。研究热老化对交直流电压在油纸绝缘内分布的影响,可为换流变压器油纸选型提供理论借鉴。选取了换流变压器常用的绝缘油和绝缘纸作为研究对象,并对2种不同油纸组合展开加速热老化试验,测量并分析试验过程中绝缘油和绝缘纸的介电常数和电阻率的变化规律,在此基础上通过油-绝缘纸-油有限元电场仿真模型分析,基于线性叠加原则,得到了交直流电压在热老化过程中的分布变化情况,表明热老化主要影响油纸中直流分量的分布,将显著提高油中的电场强度。     

Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection

Type 2 diabetes (T2D) is one of the prominent causes of morbidity and mortality in the United States and beyond, reaching global pandemic proportions. One hallmark of T2D is dysfunctional glucose-stimulated insulin secretion from the pancreatic β-cell. Insulin is secreted via the recruitment of insulin secretory granules to the plasma membrane, where the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and SNARE regulators work together to dock the secretory granules and release insulin into the circulation. SNARE proteins and their regulators include the Syntaxins, SNAPs, Sec1/Munc18, VAMPs, and double C2-domain proteins. Recent studies using genomics, proteomics, and biochemical approaches have linked deficiencies of exocytosis proteins with the onset and progression of T2D. Promising results are also emerging wherein restoration or enhancement of certain exocytosis proteins to β-cells improves whole-body glucose homeostasis, enhances β-cell function, and surprisingly, protection of β-cell mass. Intriguingly, overexpression and knockout studies have revealed novel functions of certain exocytosis proteins, like Syntaxin 4, suggesting that exocytosis proteins can impact a variety of pathways, including inflammatory signaling and aging. In this review, we present the conventional and unconventional functions of β-cell exocytosis proteins in normal physiology and T2D and describe how these insights might improve clinical care for T2D.     

Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo

Histone deacetylases (HDACs) are conserved enzymes that remove acetyl groups from lysine side chains in histones and other proteins and play a crucial role in epigenetic regulation. Previously, we showed that histone acetylation is implicated in ultraviolet (UV)-induced inflammation and matrix impairment. To elucidate the histone acetylation status and specific HDACs involved in skin aging, we examined the changes in histone acetylation, global HDAC activity, and the expression of HDACs and sirtuins (SIRTs) in intrinsically aged and photoaged human skin as well as in UV-irradiated human skin in vivo. Following acute UV irradiation, the acetylated histone H3 (AcH3) level was increased, but HDAC activity and the expression levels of HDAC4, HDAC11, and SIRT4 were significantly decreased. In intrinsically aged skin, AcH3 levels were increased, but HDAC activity and the expression levels of HDAC4, HDAC5, HDAC10, HDAC11, SIRT6, and SIRT7 were significantly decreased. However, histone acetylation and HDAC expression in photoaged skin were not significantly different from those in intrinsically aged skin. Collectively, HDAC4 and HDAC11 were decreased in both UV-irradiated and intrinsically aged skin, suggesting that they may play a universal role in increased histone acetylation associated with skin aging.     

Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging

Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAMe), a methyl donor in methylation. Over-expressed SAMe may cause neurogenic capacity reduction and memory impairment. GNMT knockout mice (GNMT-KO) was applied as an experimental model to evaluate its effect on neurons. In this study, proteins from brain tissues were studied using proteomic approaches, Haemotoxylin and Eosin staining, immunohistochemistry, Western blotting, and ingenuity pathway analysis. The expression of Receptor-interacting protein 1(RIPK1) and Caspase 3 were up-regulated and activity-dependent neuroprotective protein (ADNP) was down-regulated in GNMT-KO mice regardless of the age. Besides, proteins related to neuropathology, such as excitatory amino acid transporter 2, calcium/calmodulin-dependent protein kinase type II subunit alpha, and Cu-Zn superoxide dismutase were found only in the group of aged wild-type mice; 4-aminobutyrate amino transferase, limbic system-associated membrane protein, sodium- and chloride-dependent GABA transporter 3 and ProSAAS were found only in the group of young GNMT-KO mice and are related to function of neurons; serum albumin and Rho GDP dissociation inhibitor 1 were found only in the group of aged GNMT-KO mice and are connected to neurodegenerative disorders. With proteomic analyses, a pathway involving Gonadotropin-releasing hormone (GnRH) signal was found to be associated with aging. The GnRH pathway could provide additional information on the mechanism of aging and non-aging related neurodegeneration, and these protein markers may be served in developing future therapeutic treatments to ameliorate aging and prevent diseases.