Analogues of perillaketone as highly potent agonists of TRPA1 channel

Transient receptor potential (TRP) channels represent interesting molecular target structures involved in a number of different physiological and pathophysiological systems. In particular, TRPA1 channel is involved in nociception and in sensory perception of many pungent chemesthetic compounds, which are widespread in spices and food plants, including Perilla frutescens. A natural compound from P. frutescens (isoegomaketone) and 16 synthetic derivatives of perillaketone have been prepared and tested in vitro on rTRPA1 expressed in HEK293 cells and their potency, efficacy and desensibilisation activity measured. Most derivatives proved to be high potency agonists of TRPA1, with a potency higher than most natural agonists reported in the literature. These furylketones derivatives, represent a new class of chemical structures active on TRPA1 with many potential applications in the agrifood and pharmaceutical industry.     

Physical-layer network coding in k-users MIMO-Y two-way relay channels

In order to exchange information among k users using the technology of physical-layer network coding in the multiple input multiple output Y two-way relay channels,the GSA-GSA scheme was proposed,using the technology of general signal alignment during the uplink and the downlink.The signals were exchanged between every source node align in a transformed subspace,rather than the direct subspace.This was realized by jointly designing the precoding matrices at all source nodes and the processing matrix at the relay.The constraints of the number of sending and receiving antennas and the sum rate of proposed scheme were analyzed.In simulation,it can figure out that the proposed scheme needs fewer antennas in the whole system and can improve the achievable system sum rate under the same SNR and degrees of freedom.     

一种新型的在瑞利信道下盲检测器设计

针对采用卡尔曼滤波或线性预测方案进行信号检测时,需要已知信道模型参数或预先估计信道参数这一局限性问题,提出一种新型的瑞利信道下的盲检测器。盲检测器通过设计粒子学习算法,能够在未知的信道衰落模型参数和噪声模型参数条件下检测信号。为了提升检测器的性能,采用信号延迟判决技术。仿真结果表明,盲检测器性能优异,已接近在已知信道模型参数下检测器的性能。该盲检测器易于并行设计实现,具有很高的实用价值。     

最大比合并接收系统在n-Rayleigh信道下的性能分析

在n-Rayleigh信道下,研究了MRC(Maximal Ratio Combining)合并接收系统的平均码字错误率(ASEP)性能。基于矩生成函数(MGF)的方法,推导了MRC接收系统在n-Rayleigh衰落信道上采用M进制相移键控(MPSK),M进制正交幅度调制(MQAM)和M进制脉冲幅度调制(MPAM)等几种M进制数字调制方式的ASEP的计算式。然后在不同条件下,仿真了系统的ASEP性能,仿真值与理论值相一致,理论分析的正确性得到了证明。分析结果表明:分集支路数和衰弱因子对系统的ASEP性能有重要影响。     

浅析我国房地产企业的融资现状及对策

作为一个资金密集型产业,房地产业的运作过程对资金需求特别大。目前,中国开发商多以融资为渠道来解决资金问题。但长期的泡沫运作使房地产业的融资陷入困境,我们必须正视这个问题,探索导致该现状的原因,并加以改正。     

Q345C耐候钢多层多道焊焊接热影响区热模拟性能

焊接热影响区是焊接接头的薄弱部位,其微区力学性能不能通过常规性能测试获得。采用Gleeble 3500热模拟试验机模拟Q345C耐候钢四层四道焊热影响区,研究每道热影响区的微观组织和力学性能,结果表明:四层四道焊第二道热影响区的组织与母材相同,为铁素体和条带状珠光体,其余三道热影响区的金相组织均发生变化,为贝氏体和铁素体组织。第二道热影响区的硬度和强度最低,冲击韧性最高。     

两通道按列输出CMOS图像的非均匀性及校正方法

为确保航空遥感图像产品相对辐射质量,提出了一种对两通道按列输出CMOS(互补金属氧化物半导体)图像的非均匀性进行校正的方法。以美国仙童公司CMOS探测器CIS2521F为例,通过实验室积分球观测试验研究了暗电流噪声、平均灰度、两通道输出等因素造成的图像非均匀性;然后,基于实验室积分球观测数据,采用两点线性法,校正了由按列放大输出导致的列状条带噪声;接着,通过优化拼接线附近图像灰度差异统计结果,校正了两通道响应不一致造成的图像辐射差异。试验表明,单通道图像非均匀校正使积分球观测图像的平均非均匀度量值由4.4下降至2.4,两通道图像非均匀校正消除了两通道图像的目视差异。原始航空遥感图像经过非均匀性校正后,图像灰度均匀,能够满足遥感图像判读要求。     

Maximizing bubble segregation at high liquid fluxes

This study is concerned with a common class of problem involving two phase separation of a dispersed gas flow from a continuous liquid flow under extreme processing conditions. Relatively fine spherical bubbles of order 500 μm were generated in the presence of a surfactant under a high shear rate within a rectangular, multi-channeled, cuboidal downcomer. Liquid fluxes, as high as 176 cm/s through each channel of the downcomer, sheared bubbles from a sintered surface mounted flush to the channel wall before disengaging the downcomer flow into a vertical vessel. Both high feed fluxes, up to 15 cm/s, and high gas fluxes, up to 5.5 cm/s, ensured a high gas holdup beneath the downcomer and the hindered rising of the bubbles. Enhanced bubble–liquid segregation was achieved using an arrangement of parallel inclined channels incorporated below the main vertical chamber. This novel device, referred to as the Reflux Flotation Cell, prevented the entrainment of bubbles to the underflow, and significantly reduced the liquid flux to overflow, even in the absence of a conventional froth zone. Extreme upward bubble surface fluxes of up to 600 s⁻¹ were achieved, while counter-current downward liquid fluxes reached 14.4 cm/s, arguably four times the bubble terminal rise velocity. Hence successful phase separation was achieved while operating well beyond the so-called flooding condition arising from extreme levels of gas and feed fluxes. This hydrodynamic arrangement should find application in increasing surfactant extraction rates in foam fractionation and ion flotation, gas absorption, and even particulate flotation.     

A multi-criteria comparative analysis of different Rayleigh fading channel simulators

In this paper, an in-depth comparative analysis of the most accepted and approved Rayleigh fading channel simulators is presented. Our study addresses the three common methods for generating time-correlated Rayleigh fading processes: the inverse discrete Fourier transform (IDFT) method, the filtering white Gaussian noise (FWGN) method and the sum-of-sinusoids (SOS) method. Totally seven models, including the recently proposed models, are analyzed and compared with Clarke's reference model. We use four quantitative measures for judicious assessment of the quality of generated processes in terms of both first-order and second-order statistics. Additionally, these measures cover analysis in time domain as well as in frequency domain. An evaluation of the computational effort is also depicted. The simulation results suggest that the recently published Wang's model is very attractive and it outperforms all SOS-based models. We conclude that Zheng and Xiao's first model remains the best choice among Zheng and Xiao's family models. Several other important remarks and conclusions about the accuracy and the capability of the different Rayleigh fading simulators are driven from this study.     

Privacy from Promises to Protection

Privacy issues are becoming more and more important especially since the cyber and the real world are converging up to certain extent when using mobile devices. Means that really protect privacy are still missing. The problem is, as soon as a user provides data to a service provider the user looses control over her data. The simple solution is not to provide any data but then many useful services, e.g. navigation applications, cannot be used. In order to solve this problem, we propose privacy guaranteeing execution containers (PGEC). Basically the concept is that the application obtains access to the user data in a specially protected and certified environment, the PGEC. PGECs enable applications to access private user data and guarantee that the user data is deleted as soon as the service is quit. The PGEC also restricts the communication between the application and the service provider to what is explicitly allowed by the service user. In addition to those means the PGEC also implements countermeasures against malicious attacks such as modified host systems and covert channel attacks, which might be misusing CPU load to signal data out of the PGEC. Thus, the PGEC guarantees a “one time use” of the provided private data.