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131.
低活化比富微孔炭质天然气吸附剂的制备工艺条件研究 总被引:1,自引:0,他引:1
在低活化比[m(KOH):m(C)=2:1]前提下,以抚顺石油一厂的石油焦为原料,以KOH为主要活化剂,采用分步复合活化工艺,着重考察了原料、活化温度、活化时间、活化助剂及其用量等因素对吸附性能的影响,获得了低活化比下制备高性能天然气吸附剂的优化工艺条件:原料:100-120目石油焦:活化助剂Cy-1用量:m(Cy-1):m(C)=1:10;预活化条件:320℃保持60min;活化条件:820℃保持90min。按照该条件制备的低活化比粉状吸附剂质量吸附量达到13.5%,重复性较好。 相似文献
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133.
Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion
Xiuju Li Benjamin Buckley Konstantin Stoletov Yang Jing Marie Ranson John D. Lewis Mike Kelso Larry Fliegel 《International journal of molecular sciences》2021,22(24)
Prostate cancer is a leading cause of cancer-associated deaths in men over 60 years of age. Most patients are killed by tumor metastasis. Recent evidence has implicated a role of the tumor microenvironment and urokinase plasminogen activator (uPA) in cancer cell migration, invasion, and metastasis. Here, we examine the role of the Na+/H+ exchanger isoform 1 (NHE1) and uPA in DU 145 prostate cancer cell migration and colony formation. Knockout of NHE1 reduced cell migration. The effects of a series of novel NHE1/uPA hexamethylene-amiloride-based inhibitors with varying efficacy towards NHE1 and uPA were examined on prostate cancer cells. Inhibition of NHE1—alone, or with inhibitors combining NHE1 or uPA inhibition—generally did not prevent prostate cancer cell migration. However, uPA inhibition—but not NHE1 inhibition—prevented anchorage-dependent colony formation. Application of inhibitors at concentrations that only saturate uPA inhibition decreased tumor invasion in vivo. The results suggest that while knockout of NHE1 affects cell migration, these effects are not due to NHE1-dependent proton translocation. Additionally, while neither NHE1 nor uPA activity was critical in cell migration, only uPA activity appeared to be critical in anchorage-dependent colony formation of DU 145 prostate cancer cells and invasion in vivo. 相似文献
134.
Ana Fernández-Jiménez Inés Garcia-Lodeiro Olga Maltseva Angel Palomo 《Journal of the American Ceramic Society》2019,102(1):427-436
In this study fly ash contents of up to 50% were used to produce binders with mechanical strength greater than or equal to type CEM I 42.5R cement (reference). The specific aim pursued in this research was to determine whether the procedure used to add the chemical activator (in solid or liquid form) can affect strength development in the cement or the nature of the reaction products formed. Two experimental procedures were deployed: (a) the chemical activator was dissolved in the mixing water; (b) the chemical activator was ground, as a solid, into the fly ash. The solid-state method induced slightly higher mechanical strength than when the activator was dissolved in hydration water. The way the chemical activator was added affected not only early age reaction kinetics, but also the nature and composition of the reaction products, the liquid state favoring the formation of phases AFt and AFm. 相似文献
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136.
Rawan Altalhi Nikoletta Pechlivani Ramzi A. Ajjan 《International journal of molecular sciences》2021,22(6)
Hypofibrinolysis is a key abnormality in diabetes and contributes to the adverse vascular outcome in this population. Plasminogen activator inhibitor (PAI)-1 is an important regulator of the fibrinolytic process and levels of this antifibrinolytic protein are elevated in diabetes and insulin resistant states. This review describes both the physiological and pathological role of PAI-1 in health and disease, focusing on the mechanism of action as well as protein abnormalities in vascular disease with special focus on diabetes. Attempts at inhibiting protein function, using different techniques, are also discussed including direct and indirect interference with production as well as inhibition of protein function. Developing PAI-1 inhibitors represents an alternative approach to managing hypofibrinolysis by targeting the pathological abnormality rather than current practice that relies on profound inhibition of the cellular and/or acellular arms of coagulation, and which can be associated with increased bleeding events. The review offers up-to-date knowledge on the mechanisms of action of PAI-1 together with the role of altering protein function to improve hypofirbinolysis. Developing PAI-1 inhibitors may form for the basis of future new class of antithrombotic agents that reduce vascular complications in diabetes. 相似文献
137.
首先利用碱激发剂激发大掺量粉煤灰的活性,确定激发大掺量粉煤灰(40%)活性的Na2SiO3和Ca(OH)2的掺量;然后将废弃混凝土破碎,作为粗骨料取代部分天然碎石,以大掺量粉煤灰作为胶凝材料配制透水混凝土。结果表明:激发大掺量粉煤灰(40%)活性的单掺Na2SiO3最佳掺量为4%、单掺Ca(OH)2最佳掺量为2.5%;复掺最佳掺量为4%Na2SiO3+2.5%Ca(OH)2。再生粗骨料取代碎石的最佳取代率为20%。制备的透水混凝土坍落度为24 mm,28 d抗压强度为31.34 MPa,透水系数为2.29 mm/s,连续孔隙率达到14.4%。 相似文献
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139.
High-temperature coating for titanium aluminides using the pack-cementation technique 总被引:1,自引:0,他引:1
Si -Cheng Kung 《Oxidation of Metals》1990,34(3-4):217-228
The practical application of titanium aluminide metal-matrix composites (MMCs) at high temperatures requires suitable surface coatings to provide the needed oxidation resistance. Without a coating, the titanium aluminide alloys suffered from rapid oxidation attack at elevated temperatures, particularly under thermal cyclic conditions. The pack-cementation coating process was utilized to aluminize the surface region of a Ti3Al-base alloy to TiAl3, the most oxidation-resistant phase. With the existence of an adherent conversion coating, a thin protective alumina scale formed on the outer surface, and a significant improvement in the corrosion resistance was observed. Excellent coating efficiency and geometric flexibility were demonstrated in this study by the pack-cementation technique. Further development of the cementation process will focus on the elimination of surface cracking in the coating. 相似文献
140.