Mapping the Characteristics of a 'Good' Play Therapist.

In this pilot study, concept mapping, a methodological approach combining qualitative and quantitative analytic strategies, was used to identify the therapist qualities, competencies, and skills necessary for effective play therapy outcomes as perceived by a sub-sample of 28 experienced play therapists who are members of the Association for Play Therapy (APT). The clusters associated with the therapeutic relationship and facilitative skills (e.g., empathy, warmth, and genuineness) were rated as the most essential skills to possess and also as the most difficult to develop. In contrast, the clusters associated with play therapy interventions and theories were rated as the least important skills to possess but as the easiest to acquire. The findings are discussed, with implications for therapeutic practice, research, and policy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Review of Depression in the medically ill: An integrated approach.

Reviews the book, Depression in the medically ill: An integrated approach by G. Rodin, J. Craven, and C. Littlefield (see record 1991-97973-000). This book provides an in-depth coverage of current issues in the management of depression in the medically ill. The book is balanced in theoretical perspective and quite comprehensive in coverage of the empirical literature. The authors are well known to the area of depression and physical illness. The book is organized into three main sections dealing with 1) Clinical Presentation, 2) Etiology and Pathogenesis, and 3) Treatment. Numerous case examples are provided throughout to highlight different aspects of symptom presentation, diagnostic problems, and therapeutic management. Notably lacking from the review of prevalence studies is the work examining depression and chronic pain populations. In sum, Rodin et al. have drawn on a vast literature to provide a clear and coherent picture of the current state of knowledge and theory dealing with depression and medical illness. Their book joins a number of recent papers attempting to draw more attention to clinical issues in the management of depression in the medically ill. I would recommend the book to all clinicians who work with medically ill populations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Assessing terrestrial wildlife populations in the Toronto and Region Area of Concern

Beneficial use impairments (BUIs) under the Great Lakes Water Quality Agreement identify environmental issues requiring remedial action within the Great Lakes Areas of Concern (AOCs). We conducted this study to support the assessment of the wildlife component of BUI 3: degradation of fish and wildlife populations. We compared bird and amphibian (frogs and toads) data from the Toronto and Region Conservation Authority’s Terrestrial Long-term Monitoring Program in the Toronto and Region AOC to an adjacent, but otherwise similar, reference watershed, Duffins Creek. Twelve of 13 targets were met within the AOC for forest bird, wetland bird, meadow bird and amphibian populations based on averages of mean annual values at sites within the AOC that were within two standard deviations of averages at sites in the Duffins Creek reference watershed between 2008 and 2017. Even though wildlife populations within the AOC were within the normal range of variability expected from a reference watershed, they were often at lower levels than within the Duffins Creek reference watershed. In addition, forest bird and amphibian populations were negatively affected by urbanization within the AOC and meadow bird indices declined. We conclude that while wildlife populations within the AOC currently meet targets for BUI 3, they continue to be negatively impacted by numerous stressors that are primarily related to past and ongoing urbanization. Thus, continued restoration of wildlife habitat and protection of existing habitat within the AOC is highly recommended.     

近程防御系统中多空中目标威胁度分析

研究近程防御系统,快速打击威胁目标的控制是整个系统的主要问题。针对敌方空中目标批次较多、运动状态复杂,而我方防御火力有限,对目标进行有效、精确拦截,需要对目标威胁度排序,依次进行打击。为了正确识别对整个目标过程,进行定性和定量的分析判断,提出了一种行之有效的灰色关联分析的变权威胁度分析方法;进行仿真,生成空中多组动态飞行目标,采用上述算法对空中目标有效识别,并对威胁度进行排序,进行打击。实验结果与专家评估后的结果完全一致,并能够准确而快速的在战场做出决策。     

Non-Coding RNAs Set a New Phenotypic Frontier in Prostate Cancer Metastasis and Resistance

Prostate cancer (PCa) mortality remains a significant public health problem, as advanced disease has poor survivability due to the development of resistance in response to both standard and novel therapeutic interventions. Therapeutic resistance is a multifaceted problem involving the interplay of a number of biological mechanisms including genetic, signaling, and phenotypic alterations, compounded by the contributions of a tumor microenvironment that supports tumor growth, invasiveness, and metastasis. The androgen receptor (AR) is a primary regulator of prostate cell growth, response and maintenance, and the target of most standard PCa therapies designed to inhibit AR from interacting with androgens, its native ligands. As such, AR remains the main driver of therapeutic response in patients with metastatic castration-resistant prostate cancer (mCRPC). While androgen deprivation therapy (ADT), in combination with microtubule-targeting taxane chemotherapy, offers survival benefits in patients with mCRPC, therapeutic resistance invariably develops, leading to lethal disease. Understanding the mechanisms underlying resistance is critical to improving therapeutic outcomes and also to the development of biomarker signatures of predictive value. The interconversions between epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) navigate the prostate tumor therapeutic response, and provide a novel targeting platform in overcoming therapeutic resistance. Both microRNA (miRNA)- and long non-coding RNA (lncRNA)-mediated mechanisms have been associated with epigenetic changes in prostate cancer. This review discusses the current evidence-based knowledge of the role of the phenotypic transitions and novel molecular determinants (non-coding RNAs) as contributors to the emergence of therapeutic resistance and metastasis and their integrated predictive value in prostate cancer progression to advanced disease.     

Frequency band synthesis STAP-GMTI system architecture with the reciprocal transceiver

The reduction of the signal bandwidth and sampling frequency is conducive to the realization of antenna array thinness based on the micro system so as to improve the adaptability of the large aperture antenna on the ultra-high speed platform.However,the high-resolution range profile of the ground moving target is required for accurate tracking and recognition of the ground moving target.In order to solve this problem,a system architecture and processing method based on the low instantaneous bandwidth digital array of transceiver reciprocity is proposed,which can realize high resolution ground moving target display(GMTI) by frequency band synthesis.Because the array transceiver reciprocity can realize the coincidence of the equivalent phase center,the phase difference of the target deviated from the beam center does not need to be compensated in the process of bandwidth synthesis,and the precise synthesis of large bandwidth signals can be realized.After the synthesis of the wideband signal,the clutter is suppressed by space-time adaptive processing(STAP) to realize the detection of ground moving targets.Simulation results verify the correctness of the system architecture and processing method.     

A “Golden Age” for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system

Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious public health issue. The current therapeutic options have several disadvantages that make the search for new therapeutics urgent. Gold compounds are emerging as promising candidates based on encouraging in vitro and limited in vivo results for several Au^I and Au^III complexes. The antiparasitic mechanisms of these molecules remain only partially understood. However, a few studies have proposed the trypanothione redox system as a target, similar to the mammalian thioredoxin system, pointed out as the main target for several gold compounds with significant antitumor activity. In this review, we present the current status of the investigation and design of gold compounds directed at treating leishmaniasis. In addition, we explore potential targets in Leishmania parasites beyond the trypanothione system, taking into account previous studies and structure modulation performed for gold-based compounds.     

Revisiting Platinum-Based Anticancer Drugs to Overcome Gliomas

Although there are many patients with brain tumors worldwide, there are numerous difficulties in overcoming brain tumors. Among brain tumors, glioblastoma, with a 5-year survival rate of 5.1%, is the most malignant. In addition to surgical operations, chemotherapy and radiotherapy are generally performed, but the patients have very limited options. Temozolomide is the most commonly prescribed drug for patients with glioblastoma. However, it is difficult to completely remove the tumor with this drug alone. Therefore, it is necessary to discuss the potential of anticancer drugs, other than temozolomide, against glioblastomas. Since the discovery of cisplatin, platinum-based drugs have become one of the leading chemotherapeutic drugs. Although many studies have reported the efficacy of platinum-based anticancer drugs against various carcinomas, studies on their effectiveness against brain tumors are insufficient. In this review, we elucidated the anticancer effects and advantages of platinum-based drugs used in brain tumors. In addition, the cases and limitations of the clinical application of platinum-based drugs are summarized. As a solution to overcome these obstacles, we emphasized the potential of a novel approach to increase the effectiveness of platinum-based drugs.     

UCC项目总承包工程建设的过程管理

由成都建筑材料工业设计研究院有限公司(简称成都院)和中国建材装备有限公司组成联合体总承包的UCC 10 000 t/d熟料水泥生产线,成都院负责提供合同范围内所有的工程设计、核心技术及核心设备、现场管理、人员培训、生产线达标考核,并具体负责实施和完成所有的土建及安装工程。在总承包工程建设的过程管理中,成都院以设计为灵魂,贯彻了"工艺流程顺畅,总图布局合理,系统配置先进可靠,合理节省投资"的设计理念;成都院克服了要求高、工期短、气候条件恶劣、国外施工人员管理难度大、功效低等重重困难,按时、保质保量、安全地完成了土建、安装、调试和试车任务;2007年4月26日,该生产线一次性通过业主的达标考核。我们的经验是:(1)有专业设计院全面介入的工程总承包是项目顺利进行的可靠保证;(2)参与建设的相关单位要相互信任、相互配合、目标一致;(3)工程建设管理科学化、人性化很重要。该项目的成功建设,使成都院总包工程建设的过程管理更加正规化、合理化和科学化。