电子和β射线两用外推电离室的研制

本文研制了一台测量电子束和β射线吸收剂量的外推电离室,其空腔室壁材料可拆换并分别与空气、组织和硅等效,收集电极名义直径为1.5、3、10和30mm,空气空腔可变范围为0.2～15mm。该外推电离室具有在空腔内部测温,自动改变窗口上方材料厚度及采用微型计算机控制等特点。适用于测10 MeV能量以下,剂量率为10~5～10~(-3)Gy/h的电子或β射线吸收剂量。整个外推电离室自动测剂量系统在测~(204)TLβ放射源表面剂量率的不确定度为2.3％。测1.5 MeV电子束在硅和哈密瓜深部剂量率时,不确定度分别为4.0％和2.8％。     

Modelling of the mist formation in a segmented grinding wheel system

It has been found that using a segmented grinding wheel with a fluid chamber can significantly minimise the quantity of coolant while improving the ground surface integrity. The present investigation aims to explore the fluid flow mechanism in such a wheel system. To this end, the Weber theory for Newtonian jet instability was applied to quantitatively determine the contribution of coolant flow rate to mist and ligament modes. A semi-analytical model was then developed to predict the mist flow rate by taking into account both the grinding parameters and fluid properties. It was shown that the model prediction was in good agreement with experimental measurements. Because of the comprehensive integration of variables in the formulation, the model provides a good fundamental understanding of the mist formation and offers a practical guideline for the selection and use coolant in minimising the mist flow rate.     

敞口管型桩压入对既有受荷桩基承载性状影响

基于经典桩侧摩阻力公式和圆孔扩张理论,优化考虑土压力系数、土塞增长率、扩孔塑性半径等问题,计算新增管桩的植入对在役桩承载性状的影响. 对比分析有限元的软件与理论计算结果,发现管型桩贯入引致的桩间土挤土效应,使在役桩侧摩阻力在一定深度范围内增加,且桩长越长、桩间距越小,贡献越明显. 新增桩与在役桩的距离小于3倍桩径,会形成局部群桩效应,使群桩协同工作时的桩顶沉降增加;距离大于6倍桩径,管型桩压入对既有桩侧摩阻力、群桩协同工作效应的影响较小.     

一种基于身份的群签名方案*

群签名使得群中任何一个成员均可以代表该群进行签名,而不会暴露签名者的身份.当争议发生时,签名者的身份可以通过群管理员公开.基于身份的签名与群签名有许多相似性,给出了一个由基于身份的签名转换而来的群签名,并给出了它在电子选举中的应用实例.     

Design,Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents

To systematically evaluate the impact of neoglycosylation upon the anticancer activities and selectivity of steroids, four series of neoglycosides of diosgenin, pregnenolone, dehydroepiandrosterone and estrone were designed and synthesized according to the neoglycosylation approach. The structures of all the products were elucidated by NMR analysis, and the stereochemistry of C20-MeON-pregnenolone was confirmed by crystal X-ray diffraction. The compounds′ cytotoxicity on five human cancer cell lines was evaluated using a Cell Counting Kit-8 assay, and structure–activity relationships (SAR) are discussed. 2-deoxy-d -glucoside 5 k displayed the most potent antiproliferative activities against HepG2 cells with an IC₅₀ value of 1.5 μM. Further pharmacological experiments on compound 5 k on HepG2 cells revealed that it could cause morphological changes and cell-cycle arrest at the G0/G1 phase and then induced the apoptosis, which might be associated with the enhanced expression of high-mobility group Box 1 (HMGB1). Taken together, these findings prove that the neoglycosylation of steroids could be a promising strategy for the discovery of potential antiproliferative agents.     

Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer

Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with particular hormone receptor expression is reportedly associated with breast cancer, however, this has not been revealed in epithelial ovarian cancer (EOC). Therefore, we investigated the association between hormone receptor expression and TILs in EOC. Here we found that ERα, AR, and GR expression increased in EOC, while PR was significantly reduced and ERβ expression showed a reduced trend compared to normal epithelium. Cluster analysis indicated poor disease-free survival (DFS) in AR+/GR+/PR+ subgroup (triple dominant group); while the Cox proportional-hazards model highlighted the triple dominant group as an independent prognostic factor for DFS. In addition, significant upregulation of FoxP3+ TILs, PD-1, and PD-L1 was observed in the triple dominant group compared to other groups. NanoString analyses further suggested that tumor necrosis factor (TNF) and/or NF-κB signaling pathways were activated with significant upregulation of RELA, MAP3K5, TNFAIP3, BCL2L1, RIPK1, TRAF2, PARP1, and AKT1 in the triple dominant EOC group. The triple dominant subgroup correlates with poor prognosis in EOC. Moreover, the TNF and/or NF-κB signaling pathways may be responsible for hormone-mediated inhibition of the immune microenvironment.     

解析参数对活性焦再生过程及再生效果的影响

 活性焦的热解析参数对再生活性焦的脱硫脱硝性能和机械强度至关重要。为了明确解析参数对活性焦再生过程和再生效果的影响规律,通过热解析试验探究活性焦硫残余比例、CO₂和CO生成量及再生活性焦脱硫脱硝性能随解析温度和解析时间的变化规律,继而明确适宜的活性焦热解析参数。结果表明,活性焦升温解析过程中,脱硫产物在317 ℃左右迅速分解,随后分解速率下降;在进入恒温解析阶段后脱硫产物分解速率先快速下降,而后进入缓慢解析状态。硫残余比例随恒温解析温度的升高而下降,在530 ℃下解析3 h可使脱硫产物完全解析;解析温度高于430 ℃后,活性焦表面的酚基、醌基、内酯基等含氧官能团分解量明显增加,并随恒温解析温度的升高而持续增加,分解所生成的CO和CO₂也随之大幅增加,这将使活性焦的孔隙结构进一步发展,继而不利于活性焦机械强度的保持;解析温度低于530 ℃时,硫残余比例随解析温度的升高而持续降低,使再生活性焦的脱硫脱硝性能持续提高;解析温度高于530 ℃后,含氧官能团分解量随解析温度的升高而持续增加,这将有利于提高活性焦表面SO₂氧化反应速率,继而使再生活性焦的脱硫性能持续升高,但酚基、内酯基等酸性含氧官能团的分解使再生活性焦对NH₃的吸附性能降低,进而使其脱硝性能降低。在兼顾再生活性焦脱硫脱硝性能、机械强度和生产效率等多方面因素时,430 ℃恒温解析3 h是相对较优的解析参数。在此解析条件下,再生活性焦的硫残余比例仅为1.8%,含氧官能团尚未发生大量分解,脱硫脱硝性能相对较为优良。     

膜式水冷壁多焊机群控系统

基于DSP的多焊接电源群控系统被应用于膜式水冷壁焊机中.该系统引入优先级群控策略,多台焊接电源在外部参数发生波动时,按不同优先级的群控策略进行有序调整,减小了调整时间和调整误差.同时,根据焊接区域和焊接过程中管屏温度场分布规律,引入焊接参数实时调整策略,实现多台焊接电源在起弧段、稳弧段和收弧段等不同焊接过程的参数动态调整.结果表明,使用该系统控制焊机中的多台焊接电源,膜式水冷壁管屏焊接变形得到有效控制,焊接质量有较明显的提高.     

数据融合在电梯群控系统中的应用

将数据融合技术引入电梯群控系统中,建立了基于数据融合技术的模糊联结聚合神经网络模型,对影响电梯调度的各因素进行充分有效的数据处理后,得到的电梯控制参数作为电梯调度单元的输入.应用实例表明了该方法是方便且有效的.     

RH真空室插入管喷补车结构与性能分析

RH真空精炼装置的真空室插入管根据情况喷补耐火材料 ,其喷补设备有高架悬挂式与地面台车式两种类型。本文对这两种喷补车的结构和性能进行了分析比较 ,为喷补车的现场使用及设计研究提供了必要的依据