软锰矿浆烟气脱硫吸收液制取电解锰的工艺研究

对"软锰矿浆烟气脱硫制取电解锰、高纯碳酸锰及硫酸铵的废气脱硫资源化" 体系中脱硫吸收液制取电解锰的工艺进行了实验研究.在吸收液中先加双氧水将Fe2 氧化成Fe3 ,再加氨水调节pH值至5.5±0.5后过滤除铁,进而在滤液中按约50 mL(L(1的配比添加硫化铵, 经沉淀过滤后去除重金属.将除杂后的滤液在采用银、锡、锑、铅合金作阳极板,1Crl8Ni9Ti不锈钢板作阴极板,涤纶布作隔膜制成的电解装置进行直流电解,考查了各电解工艺参数对电流效率和槽电压的影响.结果表明电解工艺参数的较佳控制范围为:电流密度390A·m- 2左右,温度35℃左右,硫酸铵浓度110 g(L(1左右,SeO2添加量约0.04 g(L(1,槽液锰浓度约18 g(L(1,进液锰浓度约26 g(L(1,进液pH值8左右,制得的电解锰质量达到GB3418-82要求.研究结果表明,软锰矿烟气脱硫吸收液制取电解锰的工艺是可行的,开辟了一条软锰矿脱硫吸收液资源化利用的新途径.     

硫化铜矿生物堆浸过程中的覆堆技术研究

对紫金山低品位铜矿生物堆浸过程中的覆堆技术进行研究,包括覆堆经济效益对比、封堆的技术方案与过程预算分析、以及根据现场情况采用不同封堆材料进行封堆试验,提出了三层堆浸后进行封堆,在现场周边黄土缺乏的情况下,采用改性后的萃余液开路的中和渣作为封堆材料,配合土工膜的技术方案进行封堆处理。     

西南某低品位硫化铅锌矿选矿试验研究

西南某低品位铅锌矿石铅品位为2.99%、锌品位为1.57%,伴生银品位为10.80 g/t,铅、锌均主要以硫化物的形式存在。为高效开发利用该低品位矿石,对原矿分别进行了重液浮沉试验及浮选条件试验研 究。结果表明：①针对-12 mm原矿进行重液浮沉试验,在重介质悬浮液密度为2.7 kg/m3时,密度大于2.7 kg/m3产品的铅品位为10.48%、锌品位为5.37%,相对原矿品位富集近3倍;密度小于2.7 kg/m3产品的铅、锌损 失率较低,分别为4.48%和6.62%。②原矿在低碱度矿浆体系下,采用铅优先浮选—锌硫混选再分离的流程处理,最终可获得铅品位69.26%、铅回收率95.21%的铅精矿和锌品位59.83%、锌回收率84.26%的锌精矿,指标 良好。研究结果说明了该矿石预选抛尾及低碱度浮选的可行性,对低品位铅锌矿开发利用具有一定的实践意义。     

Association of Anti-EGFR Antibody and MEK Inhibitor in Gynecological Cancer Harboring RAS Mutation: A Case Series

Low-grade serous carcinoma represents a minority of serous carcinoma. Although they have better prognosis than high-grade serous carcinoma, they respond poorly to chemotherapy. Thus, it appears necessary to find other treatments such as targeted therapies. Since RAS or RAF mutations occur frequently in low-grade serous carcinoma and lead to constitutively activated MAPK cascade, MEK inhibition should be effective in the treatment of low-grade serous carcinoma. So, we wanted to evaluate the clinical benefit of MEK inhibitors in the management of advanced-stage low-grade serous carcinoma harboring KRAS or NRAS mutation. We report a case series of three women with advanced-stage low-grade serous carcinoma harboring RAS mutation who had stabilization of their disease during several months under targeted therapy combining anti-EGFR antibody and MEK inhibitor. We performed in vitro experiments, confirming the effectiveness of MEK inhibitor on the KRAS-mutated OVCAR-5 cell line, and the constitutively activation of MAPK cascade in RAS-mutated carcinoma. However, it seems that the anti-EGFR antibody does not provide any additional benefit. After whole exome analysis is carried out on the patient with the shortest response, we observed the appearance of RB1 loss-of-function mutation that could be a mechanism of resistance to MEK inhibitors in RAS- of RAF-mutated cancers. The MEK inhibitor is effective in the advanced stages of low-grade serous carcinoma harboring RAS mutation with acceptable tolerance. RB1 loss could be a mechanism of resistance to MEK inhibitors in RAS-mutated low-grade serous carcinoma.     

Property modifications of low-grade clay through physical treatments and its incidence in the pozzolanic activity

In the cement industry, it is usual to use calcined clays due to structural changes caused by thermal activations; however, there are other activation methods, such as mechanical activation by grinding. This method is not so common and has been relegated to the second level. Thus, in this work, the physical and mechanical changes in the structure of clays, induced by comminution processes, of standard clays and a low-grade kaolinitic multicomponent clay, derived from weathering of metamorphic rock, were evaluated. These changes were measured using X-ray fluorescence, X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, specific surface area (SSA) by Brunauer–Emmett–Teller method, and lime fixing as a measure of pozzolanic activity. It was found that the milling process modified the structure of the clays and the pozzolanic activity, since the main reflection (001) disappeared, the dehydroxylation temperature decreased to a maximum differential of 150°C with 120 s of milling time, especially in T:O:T clays, and the SSA increased along with the lime fixing to a maximum of 119 m²/g and 46%, respectively. In this way, the milling process is effective for the mechanical activation of the clay, especially in multicomponent clay, making it interesting for use as supplementary cementitious material.     

FFCAEs: An efficient feature fusion framework using cascaded autoencoders for the identification of gliomas

Intracranial tumors arise from constituents of the brain and its meninges. Glioblastoma (GBM) is the most common adult primary intracranial neoplasm and is categorized as high-grade astrocytoma according to the World Health Organization (WHO). The survival rate for 5 and 10 years after diagnosis is under 10%, contributing to its grave prognosis. Early detection of GBM enables early intervention, prognostication, and treatment monitoring. Computer-aided diagnostics (CAD) is a computerized process that helps to differentiate between GBM and low-grade gliomas (LGG), using the perceptible analysis of magnetic resonance (MR) of the brain. This study proposes a framework consisting of a feature fusion algorithm with cascaded autoencoders (CAEs), referred to as FFCAEs. Here we utilized two CAEs and extracted the relevant features from multiple CAEs. Inspired by the existing work on fusion algorithms, the obtained features are then fused by using a novel fusion algorithm. Finally, the resultant fused features are classified with the Softmax classifier to arrive at an average classification accuracy of 96.7%, which is 2.45% more than the previously best-performing model. The method is shown to be efficacious thus, it can be useful as a utility program for doctors.     

某极低品位含铷矿石选矿试验研究北大核心

某含铷矿石中Rb_(2)O的含量为0.046%,铷元素没有独立的矿物存在,以类质同像赋存于含钾矿物(钾长石和黑云母)中,且铷的载体矿物与脉石矿物石英紧密共生,属于极低品位难选含铷矿石。为确定该含铷矿石的选矿工艺,较好地实现资源综合利用,对其进行磨矿细度试验、捕收剂条件试验、精选条件试验和浮铷尾矿综合回收试验的研究。结果表明,确定使用组合捕收剂椰油胺+SDS和抑制剂水玻璃的药剂制度下,固定磨矿细度为-0.074 mm占65%,采用“一粗两精两扫”浮选回收黑云母和部分钾长石中的铷,浮铷尾矿经磁选—浮选回收长石的工艺。全流程闭路试验可获得Rb_(2)O品位0.114%、Rb_(2)O回收率57.23%的铷精矿和Na_(2)O品位4.21%、Na_(2)O回收率48.66%,K_(2)O品位3.96%、K_(2)O回收率31.92%,白度为69%的长石精矿,有效地回收铷资源和长石产品,为该含铷矿石工业开发提供技术支撑。