A novel biomedical titanium alloy with high antibacterial property and low elastic modulus

β-type titanium alloys have attracted much attention as implant materials because of their low elastic modulus and high strength,which is closer to human bones and can avoid the problem of stress fielding and extend the lifetime of prosthetics.However,other issues,such as the infection or inflammation postimplantation,still trouble the titanium alloy's clinical application.In this paper,we developed a novel near β-titanium alloy (Ti-13Nb-13Zr-13Ag,TNZA) with low elastic modulus and strong antibacterial ability by the addition of Ag element followed by proper microstructure controlling,which could reduce the stress shielding and bacterial infections simultaneously.The microstructure,mechanical properties,corrosion resistance,antibacterial properties and cell toxicity were studied using SEM,electrochemical testing,mechanical test and cell tests.The results have demonstrated that TNZA alloy exhibited an elastic modulus of 75-87 GPa and a strong antibacterial ability (up to 98 ％ reduction) and good biocompatibility.Moreover,it was also shown that this alloy's corrosion resistance was better than that of Ti-13Nb-13Zr.All the results suggested that Ti-13Nb-13Zr-13Ag might be a competitive biomedical titanium alloy.     

Enhanced resistance of 2205 Cu-bearing duplex stainless steel towards microbiologically influenced corrosion by marine aerobic Pseudomonas aeruginosa biofilms

An antibacterial 2205-Cu duplex stainless steel(DSS)was shown to inhibit the formation and growth of corrosive marine biofilms by direct contact with copper-rich phases and the release of Cu~(2+)ions from the2205-Cu DSS surface.In this work,the microbiologically influenced corrosion(MIC)resistance of 2205-Cu DSS in the presence of the corrosive marine bacterium Pseudomonas aeruginosa was investigated.The addition of copper improved the mechanical properties such as the yield strength,the tensile strength and the hardness of 2205 DSS.Electrochemical test results from linear polarization resistance(LPR),electrochemical impedance spectroscopy(EIS)and critical pitting temperature(CPT)measurements showed that 2205-Cu DSS possessed a larger polarization resistance(R_p),charge transfer resistance(R_(ct))and CPT values,indicating the excellent MIC resistance of 2205-Cu DSS against the corrosive P.aeruginosa biofilm.The live/dead staining results and the SEM images of biofilm confirmed the strong antibacterial ability of 2205-Cu DSS.The largest pit depth of 2205-Cu DSS was considerably smaller than that of 2205 DSS after 14 d in the presence of P.aeruginosa(2.2μm vs 12.5μm).2205-Cu DSS possessed a superior MIC resistance to regular 2205 DSS in the presence of aerobic P.aeruginosa.     

Green synthesized silver nanoparticle from Allium ampeloprasum aqueous extract: Characterization,antioxidant activities,antibacterial and cytotoxicity effects

In the current study for the first time, silver nanoparticles (AgNPs) were biosynthesized by reducing agents from hot water extract of Allium ampeloprasum, an antibacterial and anti-inflammatory edible plant. UV–vis. spectroscopy, Fourier transform infrared spectroscopy, dynamic light scattering, X-ray diffractometric, and transmission electron microscopy (TEM) analyses have been applied to confirm the formation of biosynthesized AgNPs. Total phenol content and antioxidant activities of AgNPs and extract together with their antibacterial and cytotoxic properties, were evaluated. According to TEM, AgNPs were spherical with a diameter of 8–50 nm. Total phenolic compounds were 15.58 μg/mL, and 10.94 μg/mL at a concentration of 150 μg/mL for the A. ampeloprasum extract and the biosynthesized AgNPs, respectively. Biosynthesized AgNPs showed significant antioxidant activity (81%) as compared to A. ampeloprasum extract (32%) and were active on multi-drug resistant P. aeruginosa. Besides, the cytotoxic activity response was also demonstrated that AgNPs were more potent than the A. ampeloprasum extract and showed high activity against Hela cell line with an IC₅₀ value of less than 25 µg/mL. In conclusion, AgNPs synthesized by A. ampeloprasum extract with excellent antioxidant and antibacterial effects and acceptable cytotoxicity on cervical cancer cells have the potential to be used in biological applications.     

衣物抗菌柔顺剂的研制

考察了不同配方衣物抗菌柔顺剂的抑菌能力、织物柔软性、稳定性、织物褪色程度及原材料成本，首次成功研制出除菌、柔顺合二为一的具有市场开发前景的新一代衣物柔顺剂。     

PE抗菌食品保鲜膜的研制

先将抗菌粉体制成抗菌母料，然后将抗菌母料按一定比例添加至聚乙烯原材料中，通过混匀、吹塑等工艺制备了抗菌食品保鲜膜。研究了该抗菌食品保鲜膜的抗菌性能、物理机械性能、光老化性能和卫生理化性能。发现当抗菌母料的添加量为4％时，抗菌食品保鲜膜具有抗菌效果好、抗菌谱广等特点；而它的物理机械性能没有明显变化，光老化性能良好，且卫生理化性能均符合要求。     

自洁抗菌陶瓷技术的现状和发展

介绍了自洁抗菌陶瓷的国内外发展现状及抗菌陶瓷的抗菌自洁机理，探讨了自洁抗菌陶瓷制备技术及生产中的技术难点及解决方法，并预测了国内自洁抗菌陶瓷的市场前景。     

高压均质辅助构筑CTAB改性植物精油/凹凸棒石复合抗菌材料

采用高压均质辅助构筑十六烷基三甲基溴化铵(CTAB)改性植物精油/凹凸棒石复合抗菌材料,对其进行了FTIR、XRD、SEM、Zeta电位和TG测试表征.FTIR分析表明,植物精油负载于凹凸棒石并成功实现表面改性.随CTAB用量增加,复合抗菌材料的Zeta电位由负变正.最小抑菌浓度(MIC)测试结果表明,复合材料的抗菌性能随CTAB用量的增加而增强,CTAB改性明显提升了复合材料对革兰氏阳性菌的抗菌活性.当CTAB用量为2.5％(以凹凸棒石质量为基准,下同)时,CTAB改性香芹酚/凹凸棒石复合材料和肉桂醛/凹凸棒石复合材料对金黄色葡萄球菌的MIC值由未改性的1 g/L分别减小至0.125 g/L和0.5 g/L.     

Synthesis and Characterization of Methacrylate-Based Antibacterial Copolymers for Anticorrosive Application

Functional methacrylate polymer coatings can help retard materials from corrosion. However, the antibacterial-based anticorrosive coating of methacrylate polymer is very limited. In this paper, a functional methacrylate, namely, p-acetamidophenyl methacrylate was copolymerized with N-vinylpyrrolidone and it was characterized by Fourier transform infrared spectroscopy, ¹H and ¹³C nuclear magnetic resonance spectroscopy. Thermal analyses of copolymers were studied by thermogravimetric analysis. The polymers were tested for their in vitro antibacterial activity by well diffusion method against microbes using ampicillin as a standard. The corrosion behavior of mild steel specimens coated with different ratios of copolymers has been studied by potentiodynamic polarization and electrochemical impedance spectroscopic methods. It was showed that the copolymer-coated specimens exhibited high protection efficiency than uncoated one.     

Biocompatibility,corrosion resistance and antibacterial activity of TiO2/CuO coating on titanium

In this work, TiO₂/CuO coating was prepared on titanium (Ti) by combination of magnetron sputtering and annealing treatment. The microstructure, biocompatibility, corrosion resistance and antibacterial property of TiO₂/CuO coating were investigated in comparison with pure Ti and TiO₂ coating. The results show that TiO₂/CuO coating is mainly composed of TiO₂ and CuO. In vitro cytocompatibility evaluation suggests that no obvious toxicity appears on the TiO₂/CuO coating, and the coating stimulates the osteoblast spreading and proliferation. Compared with Ti and TiO₂ coating, TiO₂/CuO coating exhibits improved corrosion resistance and antibacterial ability against S.aureus. This study is the first attempt to apply the combination of magnetron sputtering and annealing treatment to introduce the Cu into TiO₂ coating for surface modification of Ti-based implant materials, which may provide a research foundation for further development of bioactive multifunctional coatings to meet the better clinical demand.     

Synthesis of a novel nanostructured zinc oxide/baghdadite coating on Mg alloy for biomedical application: In-vitro degradation behavior and antibacterial activities

In this research, zinc oxide (ZnO) and zinc oxide/baghdadite (ZnO/Ca₃ZrSi₂O₉) were prepared on the surface of Mg alloy using physical vapor deposition (PVD) coupled with electrophoretic deposition (EPD). For this purpose, the nanostructured ZnO was prepared with a thickness of 900 nm and crystallite sizes of 64 nm as under layer while nanostructured baghdadite with a thickness of 10 µm was deposited on the Mg alloy substrate as an over-layer. Electrochemical measurement exhibited that the ZnO/Ca₃ZrSi₂O₉-coated specimen has a higher corrosion resistance and superior stability in simulated body fluid (SBF) solution in comparison with the ZnO-coated and bare Mg alloy samples. Antibacterial activities of the uncoated and coated specimens were evaluated against various pathogenic species (Escherichia coli, Klebsiella pneumoniae, and Shigella dysenteriae) via disc diffusion method. The obtained results showed that ZnO and ZnO/Ca₃ZrSi₂O₉ coatings have great zones of inhibition (ZOI) against E. coli, Klebsiella, and Shigella. However, less ZOI was found around the bare Mg alloy. Therefore, ZnO/Ca₃ZrSi₂O₉ is a promising coating for orthopedic applications of biodegradable Mg alloys considering its excellent antibacterial activities and high corrosion resistance.