Oral medication delivery in impaired swallowing: thickening liquid medications for safe swallowing alters dissolution characteristics

Acetaminophen (paracetamol) is available in a wide range of oral formulations designed to meet the needs of the population across the age-spectrum, but for people with impaired swallowing, i.e. dysphagia, both solid and liquid medications can be difficult to swallow without modification. The effect of a commercial polysaccharide thickener, designed to be added to fluids to promote safe swallowing by dysphagic patients, on rheology and acetaminophen dissolution was tested using crushed immediate-release tablets in water, effervescent tablets in water, elixir and suspension. The inclusion of the thickener, comprised of xanthan gum and maltodextrin, had a considerable impact on dissolution; acetaminophen release from modified medications reached 12–50% in 30?min, which did not reflect the pharmacopeia specification for immediate release preparations. Flow curves reflect the high zero-shear viscosity and the apparent yield stress of the thickened products. The weak gel nature, in combination with high G' values compared to G'' (viscoelasticity) and high apparent yield stress, impact drug release. The restriction on drug release from these formulations is not influenced by the theoretical state of the drug (dissolved or dispersed), and the approach typically used in clinical practice (mixing crushed tablets into pre-prepared thickened fluid) cannot be improved by altering the order of incorporation or mixing method.     

Ultrasound-assisted preparation of novel ibuprofen-loaded excipient with improved compression and dissolution properties

Context: Most of the active pharmaceutical ingredients (APIs) suffer from a drawback of poor aqueous solubility. In addition to the same, some APIs show poor tabletting behavior creating problems in formulation development. Crystal engineering can be an efficient tool in rectification of such problems associated with the APIs. Thus present work deals with crystallization of ibuprofen (a model drug) onto the surface of dicalcium phosphate (DCP) particles using different techniques.

Objective: The objective of the present work was to prepare ibuprofen-loaded DCP particles and further to analyze them for compressibility and dissolution behavior.

Materials and methods: Various crystallization techniques such as solvent evaporation (SE), melt crystallization (MC), melt sonocrystallization (MSC), antisolvent crystallization (AC), and antisolvent sonocrystallization (ASC) were screened for the preparation of ibuprofen-loaded DCP. Products obtained from different techniques were analyzed for physicochemical, micromeritic and compression properties.

Results and discussion: ASC technique was found to be suitable for preparing directly compressible ibuprofen-loaded DCP particles. The change in the crystal habit (needle to plate shape) of ibuprofen and its crystallization in miniscular form onto the surface of DCP particles showed significant improvement in the dissolution rate and compression properties of ibuprofen due to an increase in specific surface area when compared with ibuprofen crystallized by other techniques. Additionally, the tablets prepared from ASC powder did not require binder since ibuprofen acted as melt binder during compression.

Conclusion: Directly compressible ibuprofen-loaded DCP particles can serve as an alternative for conventional ibuprofen tablets prepared by wet granulation technique.     

双枝模糊集(Ⅲ)

提出双枝模糊集Ｓ的理论,本课题是［Ⅰ,Ⅱ］研究的继续．在单枝模糊集理论（Ｌ．Ａ．ＺａｄｅｈＦｕｚｚｙＳｅｔＴｈｅｏｒｙ）研究中,由于引进λ－截集Ｓλ的概念,便产生了单枝模糊集的并－普通分解定理［３］,交－普通分解定理［４］．［Ⅰ,Ⅱ］提出了双枝模糊集Ｓ,由于引进了λ－截集Ｓλ的概念,便产生了双枝模糊集Ｓ的并－普通分解定理,交－普通分解定理．人们自然提出这样的问题：双枝模糊集可以分解成若干个普通集Ｓλ;双枝模糊集Ｓ是否能分解成若干个模糊集Ｓα？本文的研究说明：双枝模糊集Ｓ可以分解成若干个模糊集Ｓα．（一个单枝模糊集Ａ也可以分解成若干个模糊集Ａα,但是在单枝模糊集理论中没有被人们去研究．）本文给出Ｓ的α－嵌入集Ｓα的概念,提出Ｓ的α－嵌入定理,Ｓ的α－嵌入模糊分解定理．     

双枝模糊集(Ⅱ)

提出双枝模糊集Ｓ的理论,是（Ｉ）研究的继续．提出双枝模糊集Ｓ的并－普通分解定理,交－普通分解定理．这些结论建立了双枝模糊集Ｓ与普通集Ｓλ之间的关系,这些结论为建立双枝模糊推理,双枝模糊控制作了理论准备．结论指出：（１）双枝模糊集Ｓ同时存在并－普通分解形式：Ｓ＝∪λ∈［－１,１］λＳλ和交－普通分解形式：Ｓ＝∩λ∈［－１,１］λＳλ;这两种分解形式是建立双枝模糊推理理论,双枝模糊控制理论的理论基础．（２）单枝模糊集Ａ（Ｌ．Ａ．ＺａｄｅｈＦｕｚｚｙＳｅｔＡ）的并－普通分解定理,交－普通分解定理是双枝模糊集Ｓ的并－普通分解定理,交－普通分解定理的特例．     

Design and realization of ad-hoc VoIP with embedded p-SIP server

In this paper we design and implement the pseudo session initiation protocol (p-SIP) server embedded in each mobile node to provide the ad-hoc voice over Internet protocol (VoIP) services. The implemented p-SIP server, being compatible with common VoIP user agents, integrates the standard SIP protocol with SIP presence to handle SIP signaling and discovery mechanism in the ad-hoc VoIP networks. The ad-hoc VoIP signaling and voice traffic performances are analyzed using E-model R rating value for up to six hops in the implemented test-bed. We also conduct the interference experiments to imitate the practical ad-hoc VoIP environment. The analyzed results demonstrate the realization of ad-hoc VoIP services by using p-SIP server.     

The EU data protection reform and the challenges of big data: remaining uncertainties and ways forward

As the first broad reform of the EU data protection legislation is being achieved, and notwithstanding EU institutions’ confident discourse, scepticism remains about the reform’s ability to safeguard the fundamental right to data protection in the face of evolving data processing techniques underlying so-called big data. Yet, one might wonder whether the cause for this difficulty should be ascribed mainly to technological progresses that the law finds it hard to deal with or rather to the policy choices embedded in the legal reform itself. Indeed, a new data protection enforcement model is being adopted, which relies heavily on risk assessment and management by the data controllers themselves. Likewise, data protection authorities see their supervisory role significantly weakened. These developments and the underlying rationality are discussed. Given the limitations of the risk-based approach as currently devised, we suggest that it be reappraised in consideration of risk regulatory experiences in other domains.     

基于时空联合性的无线传感网覆盖采样技术

覆盖采样作为无线传感器网络领域的一个基本问题,已经得到了广泛研究。但是目前研究大多只考虑空间覆盖性和网络生存周期等因素,并没有从实用的角度考虑覆盖区域的时空域覆盖特性。本文以综合考虑空间域和时间域为研究视角,提出了一种新型的以应用为导向的覆盖率指数,研究了一种基于时空联合性的无线传感网覆盖采样机制。最后通过时空覆盖率与事件侦测率指标两个指标进行了验证。     

某水库大坝巨型溶蚀大厅加固处理方案及喷锚支护参数优化研究

某RCC重力坝坝基巨型溶蚀大厅规模大,坝基以下岩体厚度小,发育深度大,坝基开挖爆破导致洞顶以上岩体松动,存在坝基塌陷的安全隐患.在充分研究区域地形地质条件的基础上,采用三维非线性有限元法研究了不同施工方案下坝基巨型溶蚀大厅的应力场、位移场及破坏区分布,并在此基础上提出溶蚀大厅的加固处理方案及喷锚支护参数.     

马克思主义精神在中央苏区时期的坚持和发展

中央苏区时期,中国共产党人树立了坚定的革命理想信仰,始终不渝地遵循马克思主义基本原则,这是革命精神的体现;在马克思主义科学世界观和方法论的指导下,不断地认识事物的本质,把握事物的规律,完整准确地理解马克思主义,这是批判精神的体现;研究和讨论完成苏区工作的具体办法,把马克思主义与苏区实际相结合,开展了轰轰烈烈的苏区建设运动,这是实践精神的体现;苏区干部为了发展的需要,运用马克思主义基本理论,不断突破常规,解决新问题,灵活地运用和发展马克思主义,这是创新精神和开放精神的体现。     

浅谈在新形势下工会如何做好群众工作

工会组织是党联系群众的纽带和桥梁。加强和改进群众工作是实现企业大发展的需要。做好群众工作必须树立群众观点,始终在感情上贴近群众;坚持以人为本,始终在行动上服务群众;创新方式方法,始终在工作上依靠群众;提高工作能力,始终在本领上适应群众。