Stearic Acid Modified Stearyl Alcohol Oleogel: Analysis of the Thermal,Mechanical and Drug Release Properties

The present study delineates the effect of stearic acid on the properties of stearyl alcohol oleogel. Herein, a series of oleogels were prepared by mixing different proportions of fatty alcohol (Stearyl alcohol; gelator) and fatty acid (stearic acid; co‐gelator). The characterization of the oleogels was done by thermal, macro‐scale stress relaxation, drug release, and antimicrobial studies. The oleogels were formed by the self‐assembly of stearyl alcohol/stearic acid. Thermal studies indicated that the stearic acid alters the crystal morphology, polymorphic transition and rate of crystallization of stearyl alcohol. The firmness of the oleogels with higher stearic proportion was better, which was due to the formation of a rigid network structure of stearyl alcohol in the presence of stearic acid. The release of ciprofloxacin hydrochloride, model drug, from the oleogels was better from the oleogels with higher stearic acid content. The release of the drug from the oleogels was Fickian diffusion‐mediated; except the oleogel with the highest stearic acid proportion. The antimicrobial study showed that the drug loaded oleogels were able to resist the growth of Escherichia coli, model microbe.     

Synthesis of Sulfur‐Based Biocompatible Nonionic Surfactants and Their Nano‐Vesicle Drug Delivery

Nonionic surfactants are capable of forming nano‐range vesicles upon self‐assembling in an aqueous medium. These vesicles are highly stable, low in toxicity, and cost‐effective. Owing to their ability to solubilize both hydrophilic and hydrophobic substances, they are of great interest for drug solubilization and delivery. This study describes the synthesis and characterization of two new nonionic surfactants and their screening for biocompatibility and drug loading potentials in nano‐scale niosomal vesicles. They were characterized through mass spectroscopy, ¹HNMR, and FT‐IR. Their critical micelle concentration (CMC) was investigated using UV–vis spectrophotometry. The biocompatibility study was carried out through blood hemolysis and in vitro cytotoxicity assays. The surfactants have very low CMC values, are highly hemo‐compatible, and were nontoxic when tested against a cell culture. They were able to form nano‐range niosomal vesicles with large variation in their size. Both new surfactants were able to encapsulate increased amounts of the drug, in this case clarithromycin. The chemical nature of the drug remained intact in the niosomal vesicles. The results suggest that these nonionic surfactants could be promising drug delivery vehicles.     

Liposome‐Containing Mechanoresponsive Hydrogels

The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof‐of‐concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded with this cargo, too. Due to the link between the hydrogel and the liposomes, a compression or other mechanical force applied to the hydrogel will rupture the liposomes and release a small percentage of the cargo. Overall, a long‐term intra‐articular drug release is feasible.

     

五台坪上泉岩溶水系统划分研究

以山西省五台坪上泉岩溶水系统为例，介绍了岩溶水系统的概况，并对甲子湾泉、大湾泉、水泉弯泉等岩溶水系统作了明确划分，提出了岩溶水各亚系统间的相互关系。     

Focusing on business projects as an area for future research: An exploratory discussion of four different perspectives

An important development in project management in recent years has been the emergence of a new class of projects, in areas such as organisational change and IT, integrated business solutions, and long-term public service delivery. Often referred to as ‘business projects’, this new class of projects (and programmes) reflects a growing conceptual shift away from the traditional engineering view of projects, towards a more business-oriented view, in which the primary concern is no longer the capital asset, system or facility etc, but increasingly the challenge of implementing business strategy, improving organisational effectiveness, and managing the realisation of stakeholder benefits. Drawing on recent research from the UK Government-funded Rethinking Project Management Network, this paper argues that future research in this area needs to look beyond the mainstream literature on project management, to other relevant disciplines such as strategic management, operations management, and the management of change. Against this background, the authors present four conceptual perspectives from the management literature, which can be usefully applied to business projects. They represent exploratory contributions from four participants in the Network – a special collaboration between researchers – whose ideas and perspectives were either discussed at the Network meetings, or are the subject of research elsewhere. Collectively, the four contributions represent an exploratory discussion of different theoretical perspectives, in order to inform and stimulate other researchers and practitioners working in the field.     

某石油化工企业高架火炬防火间距的确定

对某石油化工的企业高架火炬 ,如何采取措施 ,以确保排放到火炬系统中的丁二烯气体不再携带可燃液体 ,从而其防火间距可以按辐射热计算来确定。     

空间凸轮机构分度误差分析

定量分析了空间凸轮机构中各尺寸误差对机构转动曲线和分度精度的影响,并且用概率法给出各尺寸误差的允许变化范围.     

IBM ACS布线系统功能及优势

IBM ACS系统是一套主要面向计算机网络和电话系统的综合布线系统，它向用户提供了完整的、高质量的布线结构，ACS系统具有很强的适应性、扩展性、可靠性和长远效益。从计算机网络系统的角度出发，结合了电话系统的特点，研究了工程施工的具体情况，使综合布线系统满足计算机和电话系统的实用和美观要求。