无壳弹发射药的吸湿性和热安定性研究

测定了无壳弹发射药和参比火药：９／７单基药，双基推进剂在ＲＨ９０％￣９９％，ＲＨ７５％￣１９．５℃条件下的吸湿性。９５℃减量实验及ＤＴＡ实验结果表明，无壳弹发射药比参比火人有较大的吸湿性，而湿度对其热安定性有一定的影响。     

六硝基六氮杂异伍兹烷的吸湿性

测定了六硝基六氮杂异伍兹烷（CL－20）四种晶型产品在28℃,RH90％条件下的吸湿性。结果表明,a－CL－20的吸湿率最大,五天内达到0．5％,并随时间的延长吸湿不断增加。β,r和ε三种晶型的吸湿均不超过0．025％。     

Synthesis and dissolution behaviour of nateglinide-nicotinamide cocrystals by simple slurry crystallization

Pharmaceutical cocrystals have received increasing attention in improving drug physicochemical properties. Here, we successfully synthesized a cocrystal of nateglinide (a non-sulphonylurea hypoglycemic agent) and nicotinamide by slurry crystallization. The cocrystal formation was confirmed by powder X-ray diffraction, differential scanning calorimetry, and Fourier-transform infrared spectroscopy. The density functional theory calculation at the theoretical level of B3LYP/6–31 + G (d, p) revealed that the hydrogen bonding site of the cocrystal was formed between the carboxyl group of nateglinide and the amide bond of nicotinamide. Moreover, the cocrystal showed improved dissolution capacity in 3 pH buffers, which provides an opportunity for rapid absorption of the active ingredient.